DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rsph3 and Rsph3b

DIOPT Version :9

Sequence 1:	NP_648059.1	Gene:	Rsph3 / 38751	FlyBaseID:	FBgn0052392	Length:	659	Species:	Drosophila melanogaster
Sequence 2:	NP_001077414.1	Gene:	Rsph3b / 100037282	MGIID:	3630308	Length:	389	Species:	Mus musculus

Alignment Length:	409	Identity:	138/409 - (33%)
Similarity:	215/409 - (52%)	Gaps:	46/409 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 SSRNDTQSLAGGLHITKAQFQQQLQQRRSTSNNNNNSSSNISDKRPVVPPPEPYKNVMYDRRVIK 337
            :.||...:.|.||:...::.:....|||...:         |..:| |..|..|.|:|||||||:
Mouse     2 TDRNPRTAEASGLYTYSSRPRAVACQRRRHRD---------SILQP-VEEPMSYGNIMYDRRVIR 56

  Fly   338 GSNFG--NASLVTDVDPFD--KAAELRRRNMLRKRTMQCRNQRNVLGTPPPVKGRKHETIQTEKY 398
            |:.:.  ...:....||.:  :..:.|||.:.|||..:....|    ||.||:||||..||||.|
Mouse    57 GNTYALPTGQVPGQPDPLELQRQQQARRRALARKRAQEQLKPR----TPEPVEGRKHVDIQTELY 117

  Fly   399 LEKLVQRPPEFTIDTQTDLFLEKPPTPPFIPAKVGVDVATEIGEGELFHFDAEAQPIIDVLVDAC 463
            ||::..|..|..::.|||.||::||||.|||||.|.||||:|..||||.||.|.:|:::|||...
Mouse   118 LEEIADRIVEVDMECQTDAFLDRPPTPLFIPAKTGKDVATQILGGELFDFDLEVKPMLEVLVGKT 182

  Fly   464 IEQSMLEVAHEMELSSLRRKQEEFLAQREAELAELRRLEAEELRLQAEKERRLRQD-AIAKELDA 527
            ||||:|||..|.||::||.:|..:...|..||||::|||.:|.|.:.|||||.:|. .|..:.:.
Mouse   183 IEQSLLEVMEEEELANLRARQYAYEEIRNVELAEVQRLEEQERRHREEKERRKKQQWEIVHKRNE 247

  Fly   528 EMQKSVTAAKLLQGHIASLVPEVLENIEPAS---DAVKKEQLMKSVCPWLSAEVAEEVGHIVDSR 589
            .:|| ::|....:.::|:|:|.|.:.:..:.   |.:::: :.....|||..||.:.:.|.:..|
Mouse   248 TLQK-ISALIFARQYLANLLPSVFDKLRNSGFFYDPIERD-IEVGFLPWLMNEVEKSMEHSMVGR 310

  Fly   590 EILTAIIQEIIKQRAEIYAGYKEPESEPSG--------------PDAGVCEEEGCAIDEMEACPC 640
            .:|..:|::::::|..   .|:..|:.|.|              |.......:...:|.:.:.|.
Mouse   311 TVLDMLIRDVVERRIN---DYEHKEAMPPGQKTNVINGPNTVTDPSVTTLHTQKPVLDRVSSQPA 372

  Fly   641 ESETEMEECPEPPPPAPHL 659
            .|:..     :|.....||
Mouse   373 PSQER-----KPVEEGGHL 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rsph3	NP_648059.1	Radial_spoke_3	326..604	CDD:283702	114/285 (40%)
Rsph3b	NP_001077414.1	Radial_spoke_3	45..324	CDD:283702	114/284 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..106		13/46 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..389		10/60 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850810
Domainoid	1	1.000	196	1.000	Domainoid score	I3123
eggNOG	1	0.900	-	-		E1_2CMM4
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H12043
Inparanoid	1	1.050	203	1.000	Inparanoid score	I3739
Isobase	1	0.950	-	0	Normalized mean entropy	S7971
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006135
OrthoInspector	1	1.000	-	-		otm43988
orthoMCL	1	0.900	-	-		OOG6_104764
Panther	1	1.100	-	-	LDO	PTHR21648
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10534
SonicParanoid	1	1.000	-	-		X5066
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.730