Protein Alignment Ist1 and Ist1

DIOPT Version :10

• Sequence 1: NP_648058.1
• Gene: Ist1 / 38750
• FlyBaseID: FBgn0035715
• Length: 417
• Species: Drosophila melanogaster
• Sequence 2: NP_082294.1
• Gene: Ist1 / 71955
• MGIID: 1919205
• Length: 362
• Species: Mus musculus
• Alignment Length: 435
• Identity: 203/435 - (46%)
• Similarity: 245/435 - (56%)
• Gaps: 93/435 - (21%)

  Fly     1 MFSSGPNYNKLKTNLRLALNRLKLLEKKKAELTQKSRKEIADYLATGKTERARIRVEHIIREDYL 65
            |..||....:|:.||||.:||||||||||.||.||:|||||||||.||.||||||||||||||||
Mouse     1 MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHIIREDYL 65

  Fly    66 VEAMEMVEMYCDLLLARFGLITQMKELDTGIAEPVASLVWVCPRLQSDIAELKIISDIFVTKYGP 130
            |||||::|:||||||||||||..|||||:|:||.|::|:|..|||||::|||||::|....||..
Mouse    66 VEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIVADQLCAKYSK 130

  Fly   131 QFAEQSRT-ATGEHYVSEKLMHKLTLQAPPKLLVENYLIAIAKNYNIEYEPDPQVMQEDQP--QQ 192
            ::.:..|| ..|.  |:::|||||:::||||:|||.|||.||||||:.||||..||.| .|  .:
Mouse   131 EYGKLCRTNQIGT--VNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPDSVVMAE-APVGVE 192

  Fly   193 PHLIDL--SDRNNLSGGGGAGGGGAAPPQMGFIGYPAMPALPDMPMPPSAKPFNYP-PFGGGGGG 254
            ..|||:  :|.....|.|..||||...|..|..|...|| :| ||||....||.|| |   .|..
Mouse   193 TDLIDVGFTDDVKKGGPGRGGGGGFTAPVGGPDGIVPMP-MP-MPMPSPNAPFAYPLP---KGPS 252

  Fly   255 GGGGAPAGAYALPHPVQAPPPFAYNI-PPNQPPTHAVLPAKCAEEKDLNTNFIDREANNTDGSGS 318
            ...|.|.|.|      ||.|    || ||..|.|
Mouse   253 DFSGLPVGTY------QAFP----NIHPPQIPAT------------------------------- 276

  Fly   319 PDENILRPKPENDPPPRYTSINPVN----LQNAN--KPKPQPRSKLPPGNPTLPSAPPALD---- 373
                          ||.|.|::.:|    :.:|.  .|||:..:| ||..|        :|
Mouse   277 --------------PPSYESVDDINGDKTVSSAQIVGPKPEAPAK-PPSRP--------VDNYNT 318

  Fly   374 --FPSLPNVPNDLPDIPGAGAEKKNDEDEIDFDDLSRRFENLKKR 416
              .|.||:||:.|| ...|||.....|| |||||||||||.|||:
Mouse   319 FVLPELPSVPDTLP-TASAGASTSASED-IDFDDLSRRFEELKKK 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ist1	NP_648058.1	Ist1	12..177	CDD:460910	112/165 (68%)
		PTZ00441	<273..>400	CDD:240420	32/139 (23%)
Ist1	NP_082294.1	Ist1	12..176	CDD:460910	111/164 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	292..350		6/63 (10%)