Protein Alignment Ist1 and istr-1

DIOPT Version :9

• Sequence 1: NP_648058.1
• Gene: Ist1 / 38750
• FlyBaseID: FBgn0035715
• Length: 417
• Species: Drosophila melanogaster
• Sequence 2: NP_506170.2
• Gene: istr-1 / 179737
• WormBaseID: WBGene00010736
• Length: 445
• Species: Caenorhabditis elegans
• Alignment Length: 486
• Identity: 197/486 - (40%)
• Similarity: 240/486 - (49%)
• Gaps: 115/486 - (23%)

  Fly     3 SSGPNYNKLKTNLRLALNRLKLLEKKKAELTQKSRKEIADYLATGKTERARIRVEHIIREDYLVE 67
            |.|..|.||||||||.:|||:||.|||.|:..|:|.|||||:|..|.:||||||||||||||:||
 Worm     4 SWGAQYPKLKTNLRLGINRLQLLGKKKTEMAMKARTEIADYIAANKPDRARIRVEHIIREDYVVE 68

  Fly    68 AMEMVEMYCDLLLARFGLITQMKELDTGIAEPVASLVWVCPRLQSDIAELKIISDIFVTKYGPQF 132
            |.|::||||||||||||||.|||.||.||||.|.|::|..|||.:||||.|.|||....|||..|
 Worm    69 AFEILEMYCDLLLARFGLIEQMKTLDDGIAEAVISIMWAAPRLATDIAEFKTISDQLTIKYGKPF 133

  Fly   133 AEQSRTATGEH--YVSEKLMHKLTLQAPPKLLVENYLIAIAKNYNIEYEPDPQVMQEDQPQQPHL 195
            ||.:|....|.  .|:.|::.||...||||||||.|:|.||....:.:.|||.||:||:..|...
 Worm   134 AEAARANQLEFPARVNPKIISKLGAAAPPKLLVERYMIEIAAAAGVPFVPDPDVMREDEVHQAEQ 198

  Fly   196 IDLSDRNNLSGGGGAGGGGAAPPQMGFIGYPAMPALPDMPMPPSAKPFNYPPFGGGGGGGGGG-- 258
            |.:..:|       |||.|              |:.||.|.||.:.|:.......|..|||||
 Worm   199 ILIDFKN-------AGGNG--------------PSGPDGPPPPPSNPYGGSGNDNGSSGGGGGYG 242

  Fly   259 ------APAGAYALPH---------PVQ---APPPFAYNIPPNQPPTHAVLPAKCAEEKDLNTNF 305
                  :..|:..:||         ||.   .|||   |..||:||         .:::::..:.
 Worm   243 WNLENQSAIGSGVMPHGTAIGGGVQPVSNFIPPPP---NRHPNEPP---------QDDENIYDHI 295

  Fly   306 IDREANNTDGSGSPDENILRPKPENDPPPRYTSINP----VNLQNANKPKPQPRSKLP------- 359
            .|....|.....|.|.....|...|:.||:   .||    :||     ||..|.. ||
 Worm   296 PDVSGGNIYEVPSRDHYDFPPDAFNEEPPK---TNPTTGVINL-----PKIGPNG-LPIYPGQQQ 351

  Fly   360 ---PG---------------NPTL----PSAPPA----------LDFPSLPNV---PNDLPDIPG 389
               ||               ||.|    |:|||.          |.||..|:.   .|:.|..||
 Worm   352 PKGPGGAQAYPALSQRNSLVNPNLQPNHPTAPPQSLRKPDDFSDLSFPEPPSSFVGGNNKPGGPG 416

  Fly   390 ---AGAEKKNDEDEIDFDDLSRRFENLKKRK 417
               .|.......|  |||||:||||.|||.|
 Worm   417 GNNGGGAGNGGFD--DFDDLARRFEELKKIK 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ist1	NP_648058.1	Ist1	12..177	CDD:281401	103/166 (62%)
istr-1	NP_506170.2	Ist1	13..180	CDD:281401	103/166 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159466
Domainoid	1	1.000	194	1.000	Domainoid score	I1858
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	262	1.000	Inparanoid score	I1898
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001089
OrthoInspector	1	1.000	-	-		oto18025
orthoMCL	1	0.900	-	-		OOG6_102849
Panther	1	1.100	-	-	LDO	PTHR12161
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R620
SonicParanoid	1	1.000	-	-		X2350
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.920