DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8549 and SBDS

DIOPT Version :9

Sequence 1:	NP_001261482.1	Gene:	CG8549 / 38749	FlyBaseID:	FBgn0035714	Length:	252	Species:	Drosophila melanogaster
Sequence 2:	NP_057122.2	Gene:	SBDS / 51119	HGNCID:	19440	Length:	250	Species:	Homo sapiens

Alignment Length:	249	Identity:	147/249 - (59%)
Similarity:	185/249 - (74%)	Gaps:	2/249 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IFTPTNQIRLTNVAIVRLKKGGKRFEIACYKNKVLSWRSNSEKDIDEVLQTHTVFTNVSKGQAAK 68
            ||||||||||||||:||:|:.|||||||||||||:.|||..|||:|||||||:||.||||||.||
Human     3 IFTPTNQIRLTNVAVVRMKRAGKRFEIACYKNKVVGWRSGVEKDLDEVLQTHSVFVNVSKGQVAK 67

  Fly    69 KDELQKAFNKTDETEICKEILSKGELQVSEKERQSCLDTQLNSIVNSVAALCVNPETRRPYPASI 133
            |::|..||...|:|||||:||:|||:|||:|||.:.|:.....|...||..||||||:|||...:
Human    68 KEDLISAFGTDDQTEICKQILTKGEVQVSDKERHTQLEQMFRDIATIVADKCVNPETKRPYTVIL 132

  Fly   134 IEKSLKDAHFSVKMNRNTKQNTLEAIKILKDHMPIERSRMKLRVSFAGKEGGGKLKESVVKLANA 198
            ||:::||.|:|||.|::|||..||.||.||:.|.|||:.|:||......| |.||||.:..|...
Human   133 IERAMKDIHYSVKTNKSTKQQALEVIKQLKEKMKIERAHMRLRFILPVNE-GKKLKEKLKPLIKV 196

  Fly   199 VEHEEWDEATLHLTLLIDPGQYRVIDELVRNETKGKGLLELLELKEVVESEELF 252
            :|.|::.: .|.:..|||||.:|.||||::.||||||.||:|.||:|.|.:|.|
Human   197 IESEDYGQ-QLEIVCLIDPGCFREIDELIKKETKGKGSLEVLNLKDVEEGDEKF 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8549	NP_001261482.1	PTZ00448	4..>226	CDD:185627	130/221 (59%)
SBDS	NP_057122.2	PTZ00448	1..>223	CDD:185627	130/221 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160214
Domainoid	1	1.000	136	1.000	Domainoid score	I4947
eggNOG	1	0.900	-	-		E1_COG1500
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6438
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2817
Isobase	1	0.950	-	0	Normalized mean entropy	S584
OMA	1	1.010	-	-		QHG54247
OrthoDB	1	1.010	-	-		D1217666at2759
OrthoFinder	1	1.000	-	-		FOG0004811
OrthoInspector	1	1.000	-	-		oto88482
orthoMCL	1	0.900	-	-		OOG6_101125
Panther	1	1.100	-	-	LDO	PTHR10927
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1300
SonicParanoid	1	1.000	-	-		X3393
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750