DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment velo and si:dkey-100n23.3

DIOPT Version :9

Sequence 1:	NP_648056.1	Gene:	velo / 38748	FlyBaseID:	FBgn0035713	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	XP_005167827.1	Gene:	si:dkey-100n23.3 / 571373	ZFINID:	ZDB-GENE-070912-345	Length:	991	Species:	Danio rerio

Alignment Length:	1069	Identity:	271/1069 - (25%)
Similarity:	434/1069 - (40%)	Gaps:	236/1069 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   726 TAKITP-TQHAGALPPGTRIMQPQRPVPAAVAAPIPAPAAVTQGSSVMKTSHNNYEIHSQHVLNN 789
            ::.||| .:.|..|.|..:....|...|..:|....|.......:.:.|...:|.:||...:.:|
Zfish    14 SSNITPERRRALILSPEIKRDSRQTECPYKIARRGSAAEDECVETEMSKDRKSNNKIHWTQLASN 78

  Fly   790 RAGQEIAERD-KNSAKMLVILASGEQRLITFTLPRESCTV--QDLL------------------- 832
            ....:::.:. |.|.:.|.||....:..:...|.....|.  |.||
Zfish    79 GTSSQLSPKSTKKSNQELTILQKIHRNQVKVVLEDVLLTELGQSLLRCSGHTFQKTNQSESKKRS 143

  Fly   833 EQVGVPFDHNTTIQCVEHRGANVDFVVTVGFTVHESASELISRAE-ESLQMNRSQENQAAVAGAA 896
            :|...|...|.|...:..||       ....|..::.|...:..| :|..:|.||:   .:..:.
Zfish   144 DQTSTPTLKNKTRTSLTKRG-------ETNSTEPKATSPFHNNIESKSKSLNSSQK---LLESSE 198

  Fly   897 AAANSNPATTSASPAYAQANAAAEQAKREAASSASGNTVVGTVSSAGSAGATPSEGRKLIDGFL- 960
            .::||.....|.||   ||...::::..:.:||:.....|                 .||:|.|
Zfish   199 LSSNSRSPRESESP---QAALISKESPIQTSSSSFEENEV-----------------TLIEGSLQ 243

  Fly   961 ------AVCQ--LCGFTGVDHARCERCKRVFPEPPKRKSYVPKNSAASSPASSSSSEPVSAVPTA 1017
                  |||:  :...:.|:..|..|.|:...|....|.  .:..:..||..::..|. :.:.:.
Zfish   244 NEEVLSAVCESVISSSSPVETRRRPREKKADSELLSNKK--ERRESQESPKDAAKHEE-NHLCSN 305

  Fly  1018 ADKKRELAAARFN--NKMAGANFAVGVGVRGRGSMA----MRGGRARGGRRVPEV---------D 1067
            .:..:|:...|.:  ...||.:|.:.|......|::    :....|.....:...         |
Zfish   306 GELVQEVEGMRGSVLRLSAGTDFQIPVKRCRLDSLSEDQLLNSDLAFDTAEIRSFTLESSNFSQD 370

  Fly  1068 PVVLLSS--EDEAEGGEGTSDS--SNQPTNNSK----LNSNGNLHELSAAFPCEPNLPEIDEEPL 1124
            ..::|||  |||.||.|.|..|  :.||...:|    ::.:..::|.:.:.....::.|:.||.
Zfish   371 ETIVLSSEEEDEGEGREETKISALNIQPPEGTKDTNVVDESTTVYEQTKSPESNLSITEMSEEE- 434

  Fly  1125 YKDFSRGDVRDLSDIPEADQFSASLKCSCVRLV-PYRFEITEPVCFTTKGVRIAGILKDKDEKFE 1188
                |:|....||.:   .....|.|.|.:.:: ||:      :.|:.||..     .|...|..
Zfish   435 ----SQGIPLPLSSL---HMGGVSAKSSGIMMITPYK------ITFSLKGNS-----SDSTVKIS 481

  Fly  1189 L---NIHKQEVIKVIAHFG----NVEPAQPLVTLYLLKTCAEYVKNQLKLPDDQHHEHTGFKTHS 1246
            |   |::|..:.:....:|    ....|.|...|:|..:.|:    ..||.||......|.:...
Zfish   482 LSAINVYKYSLWEEHTLWGCDLDKDNEATPTSLLFLWLSDAQ----AHKLHDDLSVLELGTRPAE 542

  Fly  1247 YHTRRLILLFDSIS--------------VSARGNIKSMFSCVDE------ISSTDAAEILERI-- 1289
            ..|..|:.:.:.:|              ||.:|:.:...:|:.:      :.|::...:|:.:
Zfish   543 SSTCLLLCMAEPLSGIESALLCSLLDIVVSNQGSPELYCTCLTQSDSLNLLQSSEETHLLQLLTP 607

  Fly  1290 -----ADSDRKTQDKSSQPPP------RQLRADEQV--------------------SLLMY-PPK 1322
                 ..:..::||...|..|      |:.:....|                    .|:.: ||.
Zfish   608 KPDEQTSTSAQSQDSDVQLEPTYTLCHRRAQGSYNVFLAATPGAEWTPYKHCGPTRRLIQFPPPP 672

  Fly  1323 GTGGLCIRMEDFVCLTKESYLNDIIIDFYLLWLRNTLIPEPQRERTHIFSTFFYKRLTTLTRP-A 1386
            ..|.|.:..||..||....:|||:||||||.:|.....|:....|:||||:||||:||..... .
Zfish   673 SKGALTVTTEDLECLDSGEFLNDVIIDFYLKYLLVQKAPQASVARSHIFSSFFYKQLTRRDNANE 737

  Fly  1387 DMKQTAAQ-KRHARVQKWTKGVDIFDKDFIIVPINEQSHWFLAIICYPNLKGPVTFDTNQPVEPQ 1450
            |...|.|| :||.||:.||:.||||:|||:.||:|:::||:|.:||:|.|:           :||
Zfish   738 DSTSTPAQVRRHQRVRTWTRHVDIFEKDFLFVPVNQEAHWYLVVICFPGLE-----------DPQ 791

  Fly  1451 QLKRPRGKKVALQIGNTTITPLTKRAEGGQLPAALTAENVCRIADDESERDEAEGDESDMASEDS 1515
            .:||.....|.   ||           ||        |:|     .||| :|.:||....:.||.
Zfish   792 YVKRDDSASVQ---GN-----------GG--------EDV-----GESE-NETQGDHRSNSDEDK 828

  Fly  1516 ENSNSAKEPAATPTSTTASTPSLSSSQPTATGPARNIASDDVPAVKQPLILIFDSLAGASRSRVV 1580
                      :|..|...|:.||  .||..|   .|....|| .:|:|.|||.|||..:...|:.
Zfish   829 ----------STDDSRIKSSTSL--RQPDCT---ENTCKKDV-VLKRPCILIMDSLKLSIHERIF 877

  Fly  1581 ATLRDYLTCEYRVKKPDAQAHVFNKDNMPG-HCVKVPQQNNFTDCGLYLLQYVEQFFGEPIRDYR 1644
            ..||:||..|:..|:...:.  |:.:.|.| || |||.|:|.:|||||||||.|.|..:|:..:.
Zfish   878 KLLREYLQVEWETKRMGTRD--FSAERMVGSHC-KVPLQDNSSDCGLYLLQYAESFLQDPVVHFD 939

  Fly  1645 LPIKQLTNWFDFLTVTKKREDIANLIQQL 1673
            ||:: |..||....|..||::|.:||..|
Zfish   940 LPLR-LERWFPRQQVRGKRDEIRDLILHL 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
velo	NP_648056.1	Peptidase_C48	1342..>1434	CDD:304959	47/93 (51%)
si:dkey-100n23.3	XP_005167827.1	ULP1	<678..939	CDD:227489	120/318 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	189	1.000	Domainoid score	I3219
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000929
OrthoInspector	1	1.000	-	-		mtm6523
orthoMCL	1	0.900	-	-		OOG6_102905
Panther	1	1.100	-	-	LDO	PTHR46896
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1602
SonicParanoid	1	1.000	-	-		X756
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.930