DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment velo and senp2

DIOPT Version :9

Sequence 1:	NP_648056.1	Gene:	velo / 38748	FlyBaseID:	FBgn0035713	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	XP_684283.2	Gene:	senp2 / 556400	ZFINID:	ZDB-GENE-060810-183	Length:	598	Species:	Danio rerio

Alignment Length:	821	Identity:	157/821 - (19%)
Similarity:	274/821 - (33%)	Gaps:	308/821 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   865 VHESASELISRAEESLQMNRSQE--NQAAVAGAAAAA-------NSNPATTSASPAYAQANAAAE 920
            ::|..::::|.....|...:|::  ::.|...|.|||       ||.||..:....|: .:..:|
Zfish     1 MYEWIADVLSSLFLPLSAEKSEDWPSERANGKARAAATDTQRQENSRPAKRNYQSVYS-TDGVSE 64

  Fly   921 --QAKREAASSASGNTVVGTVSS--AGSAGATPSEGRKLID-----GFLAVCQLCGFTGVDHARC 976
              :.||     |..:.:|..|..  ||.||...|...:..:     .|..|.::. |.|:|.
Zfish    65 YPEVKR-----ARHDVIVRVVKKTFAGIAGLFRSRVHRKAEHEKQNAFTQVGRVT-FMGIDD--- 120

  Fly   977 ERCKRVFPEPPKRKSYVPKNSAASSPASSSSSEPVSAVPTAADKKRELAAARFNNKMAGANFAVG 1041
                            :..||.:|...|.           ..||:.|:...  |.:...||...
Zfish   121 ----------------IYSNSLSSWIESD-----------GMDKQMEMGLK--NKERTAANMQT- 155

  Fly  1042 VGVRGRGSMAMRGGRARGGRRVPEVDPVVLLSSEDEAEGGEGTSDSSNQPTNNSKL----NSNG- 1101
                  ...|:|           :.|..:|..:         ..|.|.:...:.||    .:||
Zfish   156 ------NPQALR-----------KPDGTMLYKT---------NQDRSREMRRSLKLVPSCTTNGL 194

  Fly  1102 NLHELSAAFPCEPNLPEIDEEPLYKDFSRGDVRDLSDIPEADQFSASLKCSCVRLVPYRFEITEP 1166
            |..:.....|.....|.:..|...::..|...|.|.:: .::::|.|......|:.|   .||
Zfish   195 NSRQAEMELPSRTPKPCLTVEEALRESDREHYRKLVEM-ASEKYSKSKPLPFGRIKP---SIT-- 253

  Fly  1167 VCFTTKGVRIAG---ILKDKDEKFELNIHKQEVIKVIAHFGNVEPAQPLVTLYLLKTCAEYVKNQ 1228
             .|...|.:::|   |.:..|      :::...::||          |.::::........:|::
Zfish   254 -AFPIDGHKVSGHTSICRTTD------LNRPAPVRVI----------PNISMWRDPLSLTQIKDR 301

  Fly  1229 LKLPDDQHHEHTGFKT-----HSYHTRRLILLFD-SISVSARGNIKSMFSCVDEISSTDAAEILE 1287
            ..   |.|...||...     .:..||:..:..| |..|.||.|:|...|.|..:..:.:    |
Zfish   302 TV---DGHRSTTGSDVKEGALDNQTTRKTAVDVDLSAEVEARLNLKDKDSAVGLLIPSRS----E 359

  Fly  1288 RIADSDRKTQDKSSQPPPR---QLRADEQVSLLMYPPKGTGGLC------IRMEDFVCLTKESYL 1343
            .|.|:.|:.:::.    ||   :::.:...:|....|...  ||      |...|...|.:.|:|
Zfish   360 VITDAVRRGEEEF----PRLTKEMQQEVSAALAQSDPNLV--LCSAFKLRITQRDLATLQEGSWL 418

  Fly  1344 NDIIIDFYLLWLRNTLIPEPQRE----RTHIFSTFFYKRLTTLTRPADMKQTAAQKRHARVQKWT 1404
            ||.:|:||:    |.::...::|    :.:.||||.:.:|.:             ..||.|::||
Zfish   419 NDEVINFYM----NLVMARSEQEVLGKKVYSFSTFLFPKLLS-------------GGHAAVRRWT 466

  Fly  1405 KGVDIFDKDFIIVPINEQSHWFLAIICYPNLKGPVTFDTNQPVEPQQLKRPRGKKVALQIGNTTI 1469
            |.||:|..|.|:||::...||.||::.:                       :.|.|
Zfish   467 KAVDLFLFDVILVPLHLGVHWSLAVVDF-----------------------KSKSV--------- 499

  Fly  1470 TPLTKRAEGGQLPAALTAENVCRIADDESERDEAEGDESDMASEDSENSNSAKEPAATPTSTTAS 1534
                                  |..|...:|
Zfish   500 ----------------------RSYDSMGQR---------------------------------- 508

  Fly  1535 TPSLSSSQPTATGPARNIASDDVPAVKQPLILIFDSLAGASRSRVVATLRDYLTCEYRVKKPDAQ 1599
                               .||:    ..|||:                  ||..|::|||
Zfish   509 -------------------HDDI----CDLILL------------------YLKEEFKVKK---- 528

  Fly  1600 AHVFNKDNMPGHCV-------KVPQQNNFTDCGLYLLQYVE 1633
                .||......:       ::|||.|.:|||:::.:|.:
Zfish   529 ----GKDLDVSKWIVSSLRPSEIPQQKNGSDCGVFICKYAD 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
velo	NP_648056.1	Peptidase_C48	1342..>1434	CDD:304959	30/95 (32%)
senp2	XP_684283.2	Peptidase_C48	<370..595	CDD:304959	66/356 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	71	1.000	Inparanoid score	I5303
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.860