DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment velo and Ulp1

DIOPT Version :9

Sequence 1:	NP_648056.1	Gene:	velo / 38748	FlyBaseID:	FBgn0035713	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_573362.1	Gene:	Ulp1 / 32910	FlyBaseID:	FBgn0027603	Length:	1513	Species:	Drosophila melanogaster

Alignment Length:	1617	Identity:	300/1617 - (18%)
Similarity:	509/1617 - (31%)	Gaps:	544/1617 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PLEEPVYSDLQVVQVPQDEVGSLVLQDDQQLVFNDQQQVVYQTTAPAQYQQPQQSAAPTYHIIGG 71
            ||.||  ..|..:.:..|.:  :.|..:.|:.:..||    ....|..|||       ..||..|
  Fly   179 PLPEP--PSLPTITLTVDAL--IDLDQNNQVAYYVQQ----YNNQPVLYQQ-------NIHIGTG 228

  Fly    72 DDLAHQQQ-----------QHQQQQQQQQQQQQQQQQPQ-----QQHQQQQQQVVMHHQQH---- 116
            ..|..|..           :|..|...:.|:|..|..|:     .|.|.|:.:..:..|.|
  Fly   229 IQLCDQASENNQPIILHIVEHNPQTITESQEQFHQVVPEIQINNIQEQDQKFENGISEQNHPIAT 293

  Fly   117 --QVQQVQQVHYQQQQQEPQQQQQQLHMEQQQQQQQQYVQHQPQQPAIQHTQQIYYTSEQVLQPN 179
              |.|.:.::..:.|.....|::......:.|.|.||.:...|:: .:|....: .|..||..|.
  Fly   294 EAQDQTLTEIRDENQIVLAVQEKNLTRASEIQDQNQQTLTEIPEK-CLQIASPV-TTDIQVQSPQ 356

  Fly   180 AIVQHMQQQKKQQQVLQQQQQQQQQYQQHAPAYQVQSSPQGQAQLLQSSQQQHQQAQQAQTLQLQ 244
            .::: :|:|..|.....|::..|...:.....:|..|..|||...:.:.:|.||...:.|.....
  Fly   357 VVIE-IQEQNHQSVTEIQEEVHQTAPEIQVNVFQTSSDIQGQNHQIVTEEQNHQTITETQEDYSA 420

  Fly   245 TSPPQQQ--------PQQHQQIVYRMT-------TTQQQQRPLGML--------------NNTHV 280
            .|..|.:        .:|:||||..:|       |..|.|.|..::              ::.|.
  Fly   421 VSEIQWENLSFSAEIQEQNQQIVTEVTKLASPSVTDIQAQSPQSVIEIQDDDDEDLKFESDDLHT 485

  Fly   281 IVQQQPVLIQGPQHQELIMRQAIHPYNNRVVYATSPQQQQQQ--------------------QHV 325
            |.:.|....|.||   .::.  ||..|..:.:|:..|:|.||                    |.|
  Fly   486 IPEIQEKNQQSPQ---FVIE--IHYDNEDLKFASDNQEQDQQTAELQKERFQFASEIEKRDLQIV 545

  Fly   326 IQQHVQ-------------------------QQQVQQHQQVQQQQQMQLQPTTQTAHLVQARVVP 365
            ...|.|                         |::.|.:...:..||.|||...|.:       ||
  Fly   546 TDTHKQNYHNVTDIPFATYIQEENEQLTPEDQEEDQHYLNFEGNQQFQLQKQDQLS-------VP 603

  Fly   366 Q-QTQNVVYQ-QLQVQKVQP----QQQQQAPQQQQPQLVAQQQPQLVATSAAGGTQLVRASFRKS 424
            | |.|...:: :::.:|:||    ||:.|....|:.|.: ||:..:.:..|....|.::
  Fly   604 QIQKQTHQFESKVKKRKLQPFSEYQQKGQKDHIQERQYI-QQEFTIHSNQAYSKVQYIQ------ 661

  Fly   425 PRGGAVLARPGTLITTRPTLTPTTIVR----QVRPRGGAVPGGLVRNMRPAGVRPTRAQLVVQTS 485
                       |:.|..|.:....|.:    :|:|......|...|.:               .|
  Fly   662 -----------TIQTATPYVPQLEISQENSFEVQPAYEVNEGQRDREL---------------VS 700

  Fly   486 ASGEGQTMLVTQGQMKHITISTNLGQPQQQQQQQMQQ-----QPRH-------------IYRT-H 531
            .:|......|.:       :||.|...:.|.....:.     .|.|             |.:| :
  Fly   701 YTGHEHQNFVDE-------VSTPLPPAEAQPGSTSEDISDPVSPEHWEQLESLDPSTICIRKTFN 758

  Fly   532 MVTD------GNPQQQQQQAAQQQ----PQQ-----HQQMLMMRHGPVRYRAPVSSAVAAPVQ-- 579
            ::.|      .:|:|.:.:|.::.    .|:     |:.:..:.||  |....:.|.:...::
  Fly   759 LIRDISESLVADPEQPEAEAHRKSIFLLRQKLADVCHKVLTEIIHG--RATDEIISILREILEQT 821

  Fly   580 ---APAPTAAGGGVQTSNIGMDLEERIEAAVLKKEQQKPQPTAQPVASNQLQPMQIGTGTTLTTY 641
               .|.||......:..::|:::.::|...:......:...|         .....|||......
  Fly   822 KEIPPRPTPKRDLQEDISMGLEILKKIRGMLSGWYSSRESET---------DSTDTGTGFQAQNG 877

  Fly   642 YPAGTASQEEEQQQQQQQQQQQQQQQQQVVQSQQQGIRPPSGASMTLAEYKKRQTLSASPAPVPP 706
            ...|...|.|.....|:::.|::..:                    |.:|::          |..
  Fly   878 KGFGAGRQPENSFLSQKRRNQEENPR--------------------LIKYRR----------VDN 912

  Fly   707 SNPGLAPMRATPPGTMVRPTAKITPTQHAGALPPGTRIMQPQRPVPAAVAAPIPAPAAVTQGSSV 771
            |.|                  ::...:.|..|.|...:.:..:|                  .|.
  Fly   913 SFP------------------RLITNETAEDLIPNNSMAKRDQP------------------QSS 941

  Fly   772 MKTSHNNYEIHSQHVLNNRAGQEIAERDKNSAKMLVILASGEQRLITFTLPRESCTVQDLLEQVG 836
            .:.|..|..:::||.:.|.|.......|...:...:..|....|.:|::              ..
  Fly   942 KRLSIFNPPVYTQHRVRNDAPHVPTPFDDEESSQRLANAGPSSRPMTYS--------------DA 992

  Fly   837 VPFDHNTTIQCVEHRGANVDFVVTVGFTVHESASELISRAEESLQMNRSQENQAAVAGAAAAANS 901
            |...|| .|......|.:...|......:|.|........::..|.|.....|....|:......
  Fly   993 VRLGHN-GISESRVNGHSSHTVRREPSRLHRSILSHEMNCKDQEQYNELIRTQTNYVGSRYLKPG 1056

  Fly   902 NPATTSASPAYAQANAAAEQAKREAASSAS-------GNTVVGTVSSAGSAGATPSEGRKLIDGF 959
            .|.|             .::||.::|:|:|       .|......|..|.|....:|..|||
  Fly  1057 TPPT-------------FQRAKAQSATSSSCSLQDNQSNITDSFPSPHGRANPELTEYAKLI--- 1105

  Fly   960 LAVCQLCGFTGVDHARCERCKRVFPEPPKRKSYVPKNSAAS--SPASSSSSEPVSAVPTAADKKR 1022
                        :....|..:...|:.|||.:   .||:||  |..|||:|...|...|.:..
  Fly  1106 ------------NRQENEENRSPAPQQPKRNA---SNSSASHASTISSSASSSCSTCSTCSSS-- 1153

  Fly  1023 ELAAARFNNKMAGANFAVGVGVRGRGSMAMRGGRARGGRRVPEVDPVVLLSSEDEAEGGEGTSDS 1087
                                                      :.:|:::..|.:..|..|....:
  Fly  1154 ------------------------------------------DTEPMLVKDSPEVKEANEANEAN 1176

  Fly  1088 SNQPTNNSKLNSNGNLHELSAAFPCEPNLPEIDEEPLYKDFS-----RGDVRDLSDIPEADQFSA 1147
            .....|.:|.|        .|..|....:.:.|.  |::.|:     |.|.        |:.|.|
  Fly  1177 EANEANETKEN--------DAPQPTTTRIKKPDF--LHRRFANCIFLRNDF--------AENFKA 1223

  Fly  1148 SLKCSCVRLVPYRFEITEPVCFTTKGVRIAGIL-----KDKDEKFELNIHKQEVIKVIAHFGNVE 1207
            ...         |.::        :.:.:.||.     :.|||:.......:||:     |.:..
  Fly  1224 RAN---------RRQL--------ESMHLLGIAEQQANESKDERLAYEKKLREVM-----FRSGA 1266

  Fly  1208 PAQPLVTLYLLKTCAEYVKNQLKLPDDQHHEHTGFK--THSYHTRRLILLFDSISVSARGNIKSM 1270
            |.:|...:..|:...|  |.:.||......:|..|:  |....|..||..::
  Fly  1267 PHRPFFEIGPLEQPEE--KKETKLIPLTKEDHARFQEMTTIEVTTNLIFKYN------------- 1316

  Fly  1271 FSCVDEISSTDAAEILERIADSDRKTQDKSSQPPPRQLRADEQVSLLMYPPKGTGGLCIRMEDFV 1335
                                                                    |.|..:|..
  Fly  1317 --------------------------------------------------------LQITTDDIF 1325

  Fly  1336 CLTKESYLNDIIIDFYLLWLRNTLIPEPQRER------THIFSTFFYKRLTTLTRPADMKQTAAQ 1394
            ......:|||.||:||:     :::.|...:|      |:..:|||..||             .|
  Fly  1326 TFVDGEWLNDAIINFYM-----SMLTERSEKRAGELPATYAMNTFFMPRL-------------LQ 1372

  Fly  1395 KRHARVQKWTKGVDIFDKDFIIVPIN-EQSHWFLAIICYPNLKGPVTFDT----NQP 1446
            ..:|.|::||:.||:|.||.|.||:: ...||.:|||...| |....:|:    |||
  Fly  1373 AGYAGVRRWTRKVDLFSKDIIPVPVHCGNVHWCMAIIHLRN-KTIFYYDSMGRPNQP 1428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
velo	NP_648056.1	Peptidase_C48	1342..>1434	CDD:304959	33/98 (34%)
Ulp1	NP_573362.1	Ehrlichia_rpt	200..>580	CDD:118064	82/398 (21%)
Ulp1	NP_573362.1	Peptidase_C48	1331..1506	CDD:280975	39/117 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5160
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810