DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment velo and Senp6

DIOPT Version :9

Sequence 1:	NP_648056.1	Gene:	velo / 38748	FlyBaseID:	FBgn0035713	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	NP_001100312.2	Gene:	Senp6 / 300860	RGDID:	1304565	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	1050	Identity:	256/1050 - (24%)
Similarity:	411/1050 - (39%)	Gaps:	290/1050 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   881 QMNRSQENQAAVAGAAAAANSNPA-------------TTSASPAYAQANAAAEQAKREAASSASG 932
            |.|:.::.:.........|.:||.             .|..|.:|.:     .:.||:.......
  Rat   150 QSNQDRKERKEYPPHVHKAENNPVMLSHGQGGDHVMKKTEDSESYVE-----PEVKRKVQQKRHC 209

  Fly   933 NTV-VGTVSSAGSAGAT---PSEGRKLIDGFLAVCQLCGFTGVDHARCERCKRVFPEP------- 986
            :|. :..:|.|.....|   .||.|:       .|..||....:..||:.|..||...
  Rat   210 STYQLSPLSPASKKCLTHFEVSEQRE-------CCPKCGKEKENQTRCQSCGIVFHNDLQRNCRQ 267

  Fly   987 ---------PKRKSYVPKNSAASS------PASSSSSEPVSAVP----TAADKKRELAAARFNNK 1032
                     |..::.:.:||....      .|.......|..:|    ...|..|.
  Rat   268 AVTLNESTGPLLRTSIHQNSGGQKSQNTGLTAKKFYGNSVDKIPIDILLTCDGSRH--------- 323

  Fly  1033 MAGANFAVGVGVRGRGSMAMRGGRARGGRRVPEV--------------DPVVLLSSEDEAEGGEG 1083
                |:     ::..|.:.:.||      ::|::              ||::|.|.:|:.:....
  Rat   324 ----NY-----IQTNGKVILPGG------KIPKITNPKERKTSVSDLNDPIILSSDDDDDDDRTK 373

  Fly  1084 TSDS-SNQPTN---NSKLNSNGNLHELSAAFPC----EPNLPEIDEE------------------ 1122
            ..:| |.||.:   :|...|.|.:.....|..|    ||.....:.|
  Rat   374 RRESTSPQPADSACSSPAPSTGKVEAALNANTCRAEQEPRSSPAESELNTVVIPRKARMKDQLGN 438

  Fly  1123 ----PL--YKDFSRGDVRDLSDIPEADQFSASLKCSCVRLVPYRFEITEPVCFTTKGVRIAGILK 1181
                ||  .|..:.|.:..::.:...|..|..|.|..:|:......:.|||.|:.:.::|.   .
  Rat   439 SISTPLKRRKVNTHGALIPVTSLSCQDFGSVILNCRSIRVGTLFRLLVEPVIFSLELIKIR---L 500

  Fly  1182 DKDEKFELNIHKQEVIKVIAHFGNVEPAQPLVTLYLLKTCAEYVKNQLKL----PDDQHHEHTGF 1242
            |..:..|:.::..::.|  ..:.||   :.|..::|....|.|.|..|:|    .|...::..|.
  Rat   501 DGPDSVEIILNTSDLTK--CEWCNV---RKLPVVFLQAIPAVYQKLSLQLQMSKEDKVWNDCKGI 560

  Fly  1243 -KTHSYHTRRLILL------------FDSI--SVSARGNIKSMFSCV--DEISSTDAA------- 1283
             :..|...:.:||:            |:||  .:..|.|:.:.|:.:  :|.:|...|
  Rat   561 NRITSLEEQYIILIFQTGLDHQADVVFESIITDIGIRNNVCNFFAKIPFEEANSRLVACTRSYEE 625

  Fly  1284 EILERIADSDRKTQDKSSQPPPRQLRADEQV---------------------SLLMY-PPKGTGG 1326
            .|.......:.|.:..|.: ...|||:.:::                     .|::| ||...||
  Rat   626 SIKGNCVQKENKVKTVSFE-SKIQLRSKQELQFFDDEEEAGESHTIFIGPVEKLIVYPPPPAKGG 689

  Fly  1327 LCIRMEDFVCLTKESYLNDIIIDFYLLWLRNTLIPEPQRERTHIFSTFFYKRLTTLTR--PADMK 1389
            :.:..||..||::..:|||:||||||.:|....:.:...:|.||||:||||||....|  .....
  Rat   690 ISVTNEDLHCLSEGEFLNDVIIDFYLKYLVLEKLKKEDADRIHIFSSFFYKRLNQRERRNSETTN 754

  Fly  1390 QTAAQKRHARVQKWTKGVDIFDKDFIIVPINEQSHWFLAIICYPNLKGPVTFDTN---------- 1444
            .:..||||.||:.||:.||||:||||.||:||.:|||||::|:|.|:.| .::.|
  Rat   755 LSIQQKRHGRVKTWTRHVDIFEKDFIFVPLNEAAHWFLAVVCFPGLEKP-KYEPNPHYHENAVMQ 818

  Fly  1445 QPVEPQQLKRPRGKKVALQIGNTTITPLTKRAEGGQLPAALTAENVCRIADDESERDEAEG---- 1505
            :|...:........:|.....|:...|:.|:        .|..::...:.|..:.::::|.
  Rat   819 KPSRAEDSYVSSASEVDACSQNSAAKPVIKK--------MLHRKHCLAVTDSSAAQEDSEPCYRR 875

  Fly  1506 ---------DESDMASEDSENSNSAKEPAATPTSTTASTPSL------SSSQPTATGPAR----- 1550
                     .:.:.|..::|..::.:......:..|.|...|      |:..|.|....|
  Rat   876 NAYSVKCSMKKKNHAVHENEEPSNGESACQEISDRTESEHGLQDECLNSAHHPDALSKIRLNYGD 940

  Fly  1551 -----------------------NIASDD-----------------VPAV-KQPLILIFDSLAGA 1574
                                   :.:|||                 .|.| |||.||:.|||.|.
  Rat   941 QSAEGGKLLEDELIDFSEDQDDPDDSSDDGLLADENYNSEIGQWHLKPTVCKQPCILLMDSLRGP 1005

  Fly  1575 SRSRVVATLRDYLTCEYRVKKPDAQAHVFNKDNMPGHCVKVPQQNNFTDCGLYLLQYVEQFFGEP 1639
            |||.||..||:||..|:.|||...::  |:||.|.|...||||||||:|||:|:|||||.||..|
  Rat  1006 SRSNVVKILREYLEVEWEVKKGSKRS--FSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENP 1068

  Fly  1640 IRDYRLPIKQLTNWFDFLTVTKKREDIANLIQQLMDEGNQQQRLILPVIEFPTLNGQLVEYPEDT 1704
            |.::.||: .|.|||....:..|||:|.|:|.:|.:|.::::||:                 .||
  Rat  1069 ILNFELPM-NLVNWFPPPRMKTKREEIRNIILKLQEEQSKEKRLL-----------------RDT 1115

  Fly  1705 ESAEFEEEEG 1714
            .|||....||
  Rat  1116 SSAETSLGEG 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
velo	NP_648056.1	Peptidase_C48	1342..>1434	CDD:304959	48/93 (52%)
Senp6	NP_001100312.2	Peptidase_C48	704..>816	CDD:304959	52/112 (46%)
Senp6	NP_001100312.2	Peptidase_C48	<996..1072	CDD:304959	45/77 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000929
OrthoInspector	1	1.000	-	-		otm45148
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46896
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X756
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.960