DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment velo and SENP1

DIOPT Version :9

Sequence 1:	NP_648056.1	Gene:	velo / 38748	FlyBaseID:	FBgn0035713	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	XP_016874718.1	Gene:	SENP1 / 29843	HGNCID:	17927	Length:	707	Species:	Homo sapiens

Alignment Length:	805	Identity:	155/805 - (19%)
Similarity:	272/805 - (33%)	Gaps:	249/805 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   750 PVPAAVAAPIPAPAAVTQGSSVMKTSHNNYEIHSQHVLNNRAGQEIAERDKNSAKM--------- 805
            |:.|.:..|..:|..:...:.|  :.....|:.::..|.::||.|:.....:||..
Human     4 PLTATICLPGSSPPGLCIFAKV--SDVKRLEMETRFCLISQAGLELLGSSHSSASASQSASITDD 66

  Fly   806 ---LVILASGEQRLITFTLPRESCTVQDLLEQVGVPFDHNTTIQCVEHRGANVDFVVTVGFTVHE 867
               .:.:.:||..|:.    ..|.....||.|.|.|.|.
Human    67 IADRMRMDAGEVTLVN----HNSVFKTHLLPQTGFPEDQ-------------------------- 101

  Fly   868 SASELISRAEESLQMNRSQENQAAVAGAAAAANSNPATTSASPAYAQANAAAEQAKREAASSASG 932
                 :|.:::.:..:|......:...:..:|..||:..|.:|:......:.:  .|....||:|
Human   102 -----LSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGD--LRTFGQSANG 159

  Fly   933 NTVVGTVSSAGSAGATPS------EGRKLIDGFLAVCQLCGFTGVDHARC--ERCKRVFPEPPKR 989
            .....|.||:.|...:.:      |.||...|...     .|.|..:..|  ...::.||..|
Human   160 QWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSN-----SFAGKSNHHCHVSAYEKSFPIKP-- 217

  Fly   990 KSYVPKNS-------AASSPASSSSSEPVSAVPTAADKKRELAAARFNNKMAGANFAVGVGVRGR 1047
               ||..|       :..||..:......:|..|..:::||: ..:....:.|..|.:
Human   218 ---VPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREI-YRQLLQMVTGKQFTI------- 271

  Fly  1048 GSMAMRGGRARGGRRVPEVDPVVLLSSEDEAEG--------------GEGTSDSSNQP--TNNSK 1096
                     |:.....|......|.||::..:.              |..||.|.:..  ||..:
Human   272 ---------AKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQ 327

  Fly  1097 LNSNGNLHELSAAFPCEPNLPEIDEEPLYKDFSRGDVRDLSDIPEADQFSASLKCSCVRLVPYRF 1161
            |:.  :::.||:..|               |.:.|. :|...:.......:         ||::.
Human   328 LSH--SVYSLSSYTP---------------DVAFGS-KDSGTLHHPHHHHS---------VPHQP 365

  Fly  1162 EITEPVCFTTKGVRIAGILKDKDEK--------FELNIHKQEVIKVIAHFGNVEPAQPLVTLYLL 1218
            :........::|.....:||.||.:        |:..:..:|:..|.    :....:.|..:...
Human   366 DNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVY----DSRARERLRQIEEQ 426

  Fly  1219 KTCAEYVKNQLKLPDDQHHEHTGFKTHSYHTRRLILLFDSISVSARGNIKSMFSCVDEISSTDAA 1283
            |..|..::|| :|.:.:|..|                 ||:.:..|..::.      ||..|...
Human   427 KALALQLQNQ-RLQEREHSVH-----------------DSVELHLRVPLEK------EIPVTVVQ 467

  Fly  1284 EILE---RIADSD------RKTQDKSSQPPPRQLRADEQVSLLMYPPKGTGGLCIRMEDFVCLTK 1339
            |..:   ::.||:      .:..:|..:...|....||.:|...       .|.|..:|...|..
Human   468 ETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAF-------RLTITRKDIQTLNH 525

  Fly  1340 ESYLNDIIIDFYLLWLRNTLIPEPQRER----THIFSTFFYKRLTTLTRPADMKQTAAQKRHARV 1400
            .::|||.||:||:     .::.|..:|:    .|.|:|||:.:|.|....|             |
Human   526 LNWLNDEIINFYM-----NMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQA-------------V 572

  Fly  1401 QKWTKGVDIFDKDFIIVPINEQSHWFLAI-------ICYPNLKGPVT------------------ 1440
            ::|||.||:|..|.::|||:...||.||:       |.|.:..|.:.
Human   573 KRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDK 637

  Fly  1441 ----FDTN---------QPVEPQQL 1452
                ||||         |.: |||:
Human   638 KRKEFDTNGWQLFSKKSQEI-PQQM 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
velo	NP_648056.1	Peptidase_C48	1342..>1434	CDD:304959	34/102 (33%)
SENP1	XP_016874718.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810