DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment velo and Senp7

DIOPT Version :9

Sequence 1:	NP_648056.1	Gene:	velo / 38748	FlyBaseID:	FBgn0035713	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	XP_006248306.1	Gene:	Senp7 / 288167	RGDID:	1305510	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	1057	Identity:	256/1057 - (24%)
Similarity:	394/1057 - (37%)	Gaps:	327/1057 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   820 TLPRESCTVQDL--LEQVGVPFDHNTTIQCVE--------HRGANVD-----FVVT--------- 860
            ||||....:.|.  ::...:|   :|::..:|        |:..|:.     .::|
  Rat   116 TLPRNDAKLCDTSKVQSDSLP---STSVDSIETCQRLDPLHQSLNLSERIPRVILTDIRQTELGR 177

  Fly   861 ------------VGFTVHESASELISRAEESLQMNRSQENQAAVAGAAAAANSNPATTSASPAYA 913
                        :..|....:.||.|.|:.||:   |.:|...:....:...|.|:.|....|..
  Rat   178 KYLKIPSVTEASLSDTASPKSEELSSSADGSLE---SCQNVNHLKSFLSERGSKPSRTGDISAKE 239

  Fly   914 QANA----------AAEQAKREAASSASGNTVVGTVSSAGSAGATPSEGRKLIDGFLAVCQLCGF 968
            .||.          |.|....::....|||.  |.....|::....|......|          .
  Rat   240 AANGRQEQGDDGDIAPEMVTPQSKDFNSGNK--GDYHEEGTSNKNTSYSHSETD----------H 292

  Fly   969 TGVDHARCERCKRVFPEPPKRKSYVPKN----------SAASSPASSSSSE-------PVSAVPT 1016
            |.|...|.:|.:..|......||.|.|:          |..||....|:.:       |....|.
  Rat   293 TPVSRKRKKRGRSNFHNSHNPKSSVDKSTEYIKEEENESTVSSKLEESNEDSHQDPAPPEGLTPD 357

  Fly  1017 AAD-----------KKRELAAARFN----NKMAGANFAVGV------GVRGRGSMAMR----GGR 1056
            :.:           ::.:::||...    ||.:.::.:..|      ..:|..|....    ||.
  Rat   358 SLETEATNVCSFVVQEPDVSAASGRACSPNKSSESSVSSEVAENSSAAEKGEASTVKEAPPPGGN 422

  Fly  1057 ARGGRRVPEVDPVVLLSSEDEAEGGEGTSDSSN------QPT------NNSKLNSNGNLHEL--- 1106
            :...:.:...:|:|:.|.|      ||..:..|      ||:      :.::..|:..|.||
  Rat   423 SEENQLLMSAEPIVVSSDE------EGPVEHKNSVILKLQPSQDYEFMSENQTTSDPQLSELMLG 481

  Fly  1107 --------SAAFPCEPNLPEI------DEEPLYKDF-----SRGDVRDLSDIPEADQFSASLKCS 1152
                    |...|..|::..|      .|..|..||     ..|.::..|.             .
  Rat   482 ACESVQVSSELCPYNPDMENISCINPNSEMDLKLDFIFTCVYIGKIKGTSK-------------G 533

  Fly  1153 CVRL------VPYRFEITEPVCFTTKGVRIA--GILKDKDEKFELNIHKQEVIKVIAHFGNVEPA 1209
            |:..      :|::..:.| :..|....|:.  |:.:.||:......|
  Rat   534 CITFTKKYIKIPFQVSMNE-ISLTVDTARLKRFGLWESKDDDHSKRSH----------------- 580

  Fly  1210 QPLVTLYLLKTCAEYVKNQLKLP----DDQHHEHTGFKTHSYHTRRLILLFDSISV---SARGNI 1267
             .::.|::.....:.::.||:.|    ..:.:|....:.:|..::|..|....|.:   :..|.:
  Rat   581 -AILFLWVSSNYLQDIQTQLENPMLSQQSKANEFIFLELNSPISQREELKLKDIMMEIGATNGEL 644

  Fly  1268 K--------SMFSCVDEISSTD---------AAEILERIADSDRKTQDKS--------------- 1300
            :        ..|....::|..:         :|.....:|.:|.|.:..|
  Rat   645 QLSCPLPWVQAFPLFQDLSPQEISFLHYYCASASSFPAVAGADMKKKPVSQPSNADVVKPTYTFL 709

  Fly  1301 -------------SQPPP--RQLRADEQV-SLLMYPPKGT-GGLCIRMEDFVCLTKESYLNDIII 1348
                         |.|..  |::|....| .|::|||..| |||.:..||..||.:..:|||:||
  Rat   710 HKQSSGCYSLSITSSPDEEWREVRNTGPVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDVII 774

  Fly  1349 DFYLLWLRNTLIPEPQRERTHIFSTFFYKRLT----TLTRP-ADMKQTAAQKRHARVQKWTKGVD 1408
            ||||.:|......:...||:||||:||||.||    .||.. .|:  :.||:||.||:.||:.::
  Rat   775 DFYLKYLLLEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPDL--SVAQRRHRRVRTWTRHIN 837

  Fly  1409 IFDKDFIIVPINEQSHWFLAIICYPNLKGPVTFDTNQPVEPQQLKRPRGKKVALQIGNTTITPLT 1473
            ||:||:|.||:||.|||:||:||:|.|:..|..|..|.|..:
  Rat   838 IFNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDFPQTVSQE----------------------- 879

  Fly  1474 KRAEGGQLPAALTAENVCRIADDESERDEAEGDESDMASEDSENSNSAKEPAATPTSTTASTPSL 1538
                               ..|.:|:.|               |.....:|..|.|..|    |.
  Rat   880 -------------------FQDQQSQHD---------------NKTIDNDPHTTSTVFT----SA 906

  Fly  1539 SSSQPTATGPARNIASDDVP--AVKQPLILIFDSLAGASRSRVVATLRDYLTCEYRVKKPDAQAH 1601
            ..||.|.|       |..||  ..|:|.|||.|||..||....|..||:||..|:.||:   :.|
  Rat   907 EESQSTET-------SMSVPKKMCKRPCILILDSLKAASIQNTVQNLREYLEVEWEVKR---KTH 961

  Fly  1602 -VFNKDNMPGHCVKVPQQNNFTDCGLYLLQYVEQFFGEPIRDYRLPIKQLTNWFDFLTVTKKRED 1665
             .|:|.||...|.|||:|:|.:|||:|||||||.||.:||.::.||| .|..||....:..||||
  Rat   962 REFSKTNMVDLCPKVPKQDNSSDCGVYLLQYVESFFQDPIVNFELPI-HLEKWFPRHVIKTKRED 1025

  Fly  1666 IANLIQQLMDEGNQQQR 1682
            |..||.:|   ..|||:
  Rat  1026 IRELILKL---HLQQQK 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
velo	NP_648056.1	Peptidase_C48	1342..>1434	CDD:304959	49/96 (51%)
Senp7	XP_006248306.1	ULP1	<749..1004	CDD:227489	122/327 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I3826
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000929
OrthoInspector	1	1.000	-	-		otm63540
orthoMCL	1	0.900	-	-		OOG6_102905
Panther	1	1.100	-	-	LDO	PTHR46896
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X756
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.860