Protein Alignment velo and SENP3

DIOPT Version :10

• Sequence 1: NP_648056.1
• Gene: velo / 38748
• FlyBaseID: FBgn0035713
• Length: 1833
• Species: Drosophila melanogaster
• Sequence 2: NP_056485.2
• Gene: SENP3 / 26168
• HGNCID: 17862
• Length: 574
• Species: Homo sapiens
• Alignment Length: 843
• Identity: 155/843 - (18%)
• Similarity: 247/843 - (29%)
• Gaps: 384/843 - (45%)

  Fly   938 TVSSAGSAGATPSEGRKLIDGFLAVCQLCGFTGVDHA----RCERCKRVFPEPPK---------- 988
            |:...||.|..|..                 .|:..|    |.||.:  :|.|||
Human     4 TIQGTGSWGPEPPG-----------------PGIPPAYSSPRRERLR--WPPPPKPRLKSGGGFG 49

  Fly   989 -----------RKSYVPKNSAASSPASSSSSEPVSAVPTAADKKRELAAARFNNKMAGANFAVGV 1042
                       |:..||:   .|..||:|..|.........|::.|:||.|...:.:    .:|.
Human    50 PDPGSGTTVPARRLPVPR---PSFDASASEEEEEEEEEEDEDEEEEVAAWRLPPRWS----QLGT 107

  Fly  1043 GVRGRGS-------------MAMRG-------------------GRARGGRRVPEVDPVVLLSSE 1075
            ..|.|.|             .|||.                   ||.||.|| ....|...||.:
Human   108 SQRPRPSRPTHRKTCSQRRRRAMRAFRMLLYSKSTSLTFHWKLWGRHRGRRR-GLAHPKNHLSPQ 171

  Fly  1076 DEAEGGEGTSDSSNQPTNNSKLNSN--------GNLHELSA-----AFPCEPNLPEIDEEPLYKD 1127
               :||.    :...|:...:.:|.        |.|..|.|     ..|..|:.|.::|:.|
Human   172 ---QGGA----TPQVPSPCCRFDSPRGPPPPRLGLLGALMAEDGVRGSPPVPSGPPMEEDGL--- 226

  Fly  1128 FSRGDVRDLSDIPEADQFSASLKCSCVRLVPYRFEITEPVCFTTKGVRIAGILKDKDEKFELNIH 1192
                  |.....| .|..|..|.|:    :|..|               .|....:.|:
Human   227 ------RWTPKSP-LDPDSGLLSCT----LPNGF---------------GGQSGPEGER------ 259

  Fly  1193 KQEVIKVIAHFGNVEPAQPLVTLYLLKTCA--EYVKNQLKLPDD----QHHEHTGFKTHSYHTRR 1251
                          ..|.|..::.:...|:  ::|..:|....|    :..|..|.|...:...|
Human   260 --------------SLAPPDASILISNVCSIGDHVAQELFQGSDLGMAEEAERPGEKAGQHSPLR 310

  Fly  1252 LILLFDSISVSARGNIKSMFSCVDEI---------SSTDAAEILERIADSDRKTQDKSSQPPPRQ 1307
                        ..::..:.|.:||.         .|||  |::|::.|.   .|.:.|.|..:.
Human   311 ------------EEHVTCVQSILDEFLQTYGSLIPLSTD--EVVEKLEDI---FQQEFSTPSRKG 358

  Fly  1308 LRADEQVSLLMYPPKGTGGLCIR------------MEDFVCLTKESYLNDIIIDFYLLWLRNTLI 1360
            |    .:.|:....:..|...:|            |:|...|..:::|||.:::.|     ..|:
Human   359 L----VLQLIQSYQRMPGNAMVRGFRVAYKRHVLTMDDLGTLYGQNWLNDQVMNMY-----GDLV 414

  Fly  1361 PEPQRERTHIFSTFFYKRLTTLTRPADMKQTAAQKRHARVQKWTKGVDIFDKDFIIVPINEQSHW 1425
            .:...|:.|.|::|||.:|.|             |.:..|::|||.||||:|:.:::||:.:.||
Human   415 MDTVPEKVHFFNSFFYDKLRT-------------KGYDGVKRWTKNVDIFNKELLLIPIHLEVHW 466

  Fly  1426 FLAIICYPNLKGPVTFDTNQPVEPQQLKRPRGKKVALQIGNTTITPLTKRAEGGQLPAALTAENV 1490
            .|                                :::.:...|||
Human   467 SL--------------------------------ISVDVRRRTIT-------------------- 479

  Fly  1491 CRIADDESERDEAEGDESDMASEDSENSNSAKEPAATPTSTTASTPSLSSSQPTATGPARNIASD 1555
                                                                             
Human   480 ----------------------------------------------------------------- 479

  Fly  1556 DVPAVKQPLILIFDSLAGASRSRVVATLRDYLTCEYRVKKPDAQAHVFNKDNMPGH-------CV 1613
                       .|||....:| |....:..||           ||....||.:..|       .:
Human   480 -----------YFDSQRTLNR-RCPKHIAKYL-----------QAEAVKKDRLDFHQGWKGYFKM 521

  Fly  1614 KVPQQNNFTDCGLYLLQYVEQFFGEPIRDYRLPIKQLTNWFDFLTVTKKREDIANLIQQLMDE 1676
            .|.:|||.:|||.::|||.:..             .|:..|.|     .::|:..|.:|:..|
Human   522 NVARQNNDSDCGAFVLQYCKHL-------------ALSQPFSF-----TQQDMPKLRRQIYKE 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
velo	NP_648056.1	Peptidase_C48	1342..>1434	CDD:420019	28/91 (31%)
SENP3	NP_056485.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..125		31/146 (21%)
		Nuclear localization signal. /evidence=ECO:0000255	125..128		0/2 (0%)
		Nuclear localization signal. /evidence=ECO:0000255	153..159		3/5 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..181		5/26 (19%)
		SENP3_5_N	<295..388	CDD:466160	20/113 (18%)
		Protease	386..543		56/314 (18%)
		Peptidase_C48	400..572	CDD:397169	60/343 (17%)