DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment velo and senp7b

DIOPT Version :9

Sequence 1:	NP_648056.1	Gene:	velo / 38748	FlyBaseID:	FBgn0035713	Length:	1833	Species:	Drosophila melanogaster
Sequence 2:	XP_005161832.1	Gene:	senp7b / 100006377	ZFINID:	ZDB-GENE-060531-45	Length:	884	Species:	Danio rerio

Alignment Length:	1011	Identity:	239/1011 - (23%)
Similarity:	384/1011 - (37%)	Gaps:	312/1011 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   814 QRLITFTLPR-----ESCTVQDLLEQVGVPFDHNTTIQCVEHRGANVDFVVTVGFTVHESAS--E 871
            |..::|.:|:     :||:: |:...:....|.|:.    :.:..:|.|   .|.|.|:::|  .
Zfish    19 QMAVSFRIPKKKQPSDSCSL-DMQSPLSRLQDDNSQ----KSQWGSVTF---NGRTPHKTSSNEN 75

  Fly   872 LISRAEESLQMNRS--------QENQAAVAGAAAAANSNP-------------ATTSASPAYAQA 915
            ::|:..:.....|.        :.||..:..:.|..|..|             .|.:.:|.:...
Zfish    76 MLSKDSQRSDSLRGATRGRFSFKMNQQPIKISPARVNGTPHKVSDTSGFRPQCQTPTTAPDFTAN 140

  Fly   916 N--------------------------------AAAEQAKREAASSASGNTVVG----------- 937
            |                                ..:|:.:.|......|::.|.
Zfish   141 NRWRPKRASDRLLSHDENHTKASECSAFKIHRGLDSEELEEEETEGTQGHSQVKETQRATSSEDY 205

  Fly   938 TVSSAGSAGATPSEGRKLIDGFLAVCQLCGFTGVDHARCERCKRVFPEPPKRKSYVPKNSAASSP 1002
            .|:||.|.....:...|              .|.:.|    ..:.|..........|.....:|.
Zfish   206 KVTSAASVFEKATSKHK--------------NGTEKA----VSKPFNHSGLHVQEAPARHLRTSE 252

  Fly  1003 ASSSSSEPVSAVP----TAADKKRELAAARFNNKMAGANFAVGVGVRGRGSMAMRGGRARGGRRV 1063
            ..::||.||...|    ||.:|.::..|:.:::|:                           ||.
Zfish   253 ERAASSVPVRKDPLTSETAENKSKDPFASFYSSKL---------------------------RRK 290

  Fly  1064 PE-------------VDPVVLLSSEDE-------AEGG-------EGTSDSSNQPTNNSKLNSNG 1101
            |:             .:|:| |||:||       ..||       ||..|:......:||.|..|
Zfish   291 PQSFCKTYKRTKPSSTEPIV-LSSDDEGANEVNDVSGGLQEQRISEGIRDTQTGNQKSSKTNVGG 354

  Fly  1102 NLHELSAAFPCEPNLPEIDEEPLYKDFSRGDVRD---LSD----IP--EAD-QFSASLKCSCVRL 1156
               |.|......|::.|::...|:.|..:.....   ::|    ||  :|| :...::..||.:|
Zfish   355 ---ERSTTKVEVPSIMELEFSRLHYDTIQAQANGTVVITDEGISIPLKDADGEGEVAISISCSQL 416

  Fly  1157 VPYRFEITEPVCFTTKGVRIAGILKDKDEKFELNIHKQEVIKVIAHFGNV-----EPAQPLVTLY 1216
            ..|             |:...|:..|                     |::     |||..|..|.
Zfish   417 QMY-------------GMWDGGLASD---------------------GSLLSITEEPAPSLFFLM 447

  Fly  1217 LLKTCAEYVKNQLKLPDDQHHEHTGFKTHSY------------HTRRLILLFDSISVS-ARGNIK 1268
            :....|..::.:|.|   |::.||..:...:            ....|..|.|.|.:. |:.::.
Zfish   448 VSDAQARLLRKELSL---QYNTHTSGQACPFVLLVLSGQLDDLRVALLASLMDVIGLRYAQDSLS 509

  Fly  1269 SMFSCVDEIS----STDAAEILERIADSDRKT-QDKS-------SQPPPRQ-LRADEQVS----- 1315
            :..|..|.:|    .......|..:..:.:.| |||:       .:|..|: ||:..:..
Zfish   510 NPVSWADGLSRLLCHPRGEHFLSLLGQNCKDTGQDKAKENASGIKEPTARRPLRSHSKPQSLPRR 574

  Fly  1316 LLMY-PPKGTGGLCIRMEDFVCLTKESYLNDIIIDFYLLWLRNTLIPEPQRERTHIFSTFFYKRL 1379
            |:.| ||...||:.:..||..||....:|||:||||||.:|......:...||:||||:||||:|
Zfish   575 LIQYPPPPSKGGITVTTEDLECLKDGEFLNDVIIDFYLKYLLLERADKDIAERSHIFSSFFYKQL 639

  Fly  1380 T--TLTRPADMKQTAAQKRHARVQKWTKGVDIFDKDFIIVPINEQSHWFLAIICYPNLKGPVTFD 1442
            |  ..:.|.:...|:|.:||.||:.||:.||||.||::.:|:|.::||:|.:||:|.|:.|
Zfish   640 TRKDTSGPEETGSTSAYRRHQRVRTWTRHVDIFSKDYLFIPVNHEAHWYLVLICFPALERP---- 700

  Fly  1443 TNQPVEPQQLKRPRGKKVALQIGNTTITPLTKRAEGGQLPAALTAENVCRIADDESERDEAE--- 1504
                    |:...|.|....|..:.|    ||....|                 ||:|:.::
Zfish   701 --------QIVEWRQKSSVSQDESQT----TKERPSG-----------------ESQRESSQQPK 736

  Fly  1505 GDESDMASEDSENSNSAKEPAATPTSTTASTPSLSSSQPTATGPARNIASDDVPAVKQPLILIFD 1569
            |:.|.:....|.|.     |..|..|.|..|                       ..|:|.|||.|
Zfish   737 GNPSKINESRSHNL-----PDCTVHSCTKET-----------------------ICKRPCILIMD 773

  Fly  1570 SLAGASRSRVVATLRDYLTCEYRVKKPDAQAHVFNKDNMPGHCVKVPQQNNFTDCGLYLLQYVEQ 1634
            ||..:...|....||:||..|:.|:|...::  |:.:::.|...:||.|:|.:|||||||||||.
Zfish   774 SLKLSYHQRTYTLLREYLQVEWEVRKGSCRS--FSNESITGSLCRVPLQDNSSDCGLYLLQYVES 836

  Fly  1635 FFGEPIRDYRLPIKQLTNWFDFLTVTKKREDIANLI 1670
            |...|:.|:.||:: |..||....|.|||||:..|:
Zfish   837 FLQNPVVDFALPLR-LDQWFPRSQVRKKREDLRELV 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
velo	NP_648056.1	Peptidase_C48	1342..>1434	CDD:304959	44/93 (47%)
senp7b	XP_005161832.1	Peptidase_C48	601..845	CDD:304959	102/306 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	189	1.000	Domainoid score	I3219
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000929
OrthoInspector	1	1.000	-	-		mtm6523
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46896
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1602
SonicParanoid	1	1.000	-	-		X756
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	8.030