DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dikar and BDF2

DIOPT Version :9

Sequence 1:	NP_001261480.1	Gene:	dikar / 38747	FlyBaseID:	FBgn0261934	Length:	3261	Species:	Drosophila melanogaster
Sequence 2:	NP_010213.1	Gene:	BDF2 / 851488	SGDID:	S000002228	Length:	638	Species:	Saccharomyces cerevisiae

Alignment Length:	760	Identity:	157/760 - (20%)
Similarity:	258/760 - (33%)	Gaps:	229/760 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   756 SSLNNNNNHKH-----APHHSHNNNNNSHSTTTSAT--------------TTATTTTSQGYHYNS 801
            |..|.:..|.|     ||..:..|:.:|:|::.|::              ..:..:...|.|:..
Yeast     2 SRTNMDTRHAHSALLAAPQSATANSRSSNSSSESSSNKNNINVGVGDDSGNVSAVSIDDGPHFRD 66

  Fly   802 --NLNHNQNHQNSHSHHTHHHHHHHHHTTNNHSNKHKTKSHHSLAHNNNNNNSPTTNPTSTSLLH 864
              :..|.:|::.:.|..|:         .|:.|:.|:|.|..|:    :|.::|.:.|.     |
Yeast    67 IFHYGHEENYKLASSGITN---------LNSSSHAHQTLSPISI----SNASTPESFPE-----H 113

  Fly   865 PVTTNNNSTYNSSNHANILSFTETEEVLQIGMH---------KVLV----YVKNHRDAWPF---V 913
            |:....                |||..|:..|.         |.|:    ..|..:||.||   |
Yeast   114 PLGLER----------------ETEPALEAEMEAEELPPHQSKYLLSSIKATKRLKDARPFLKPV 162

  Fly   914 DPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMVN 978
            ||:..:| |.|::.::.||||..:|.||....||...:..:||:.:|:||..:||..:..:.|..
Yeast   163 DPIALNI-PHYFNYVQTPMDLSLIETKLQGNVYHSVEQVTSDFKTMVDNCLNFNGPESSISSMAK 226

  Fly   979 NLQDAFEK-------------ATKKYFDNLSDDEDDDPNLSYPAADSKMNVFREKYFSKKAKEET 1030
            .:|..|||             |.||...|...:||.|..|....:.|..|   :.......:|..
Yeast   227 RIQKYFEKKLSAMPPRVLPASALKKTSRNRKKNEDMDSPLVIRRSVSTTN---DNIGESGNREGV 288

  Fly  1031 EKDAPGRPAVSSAEEDLSEIEAEAPQKAQKRKRKEKDKRRKKKT----------KSKADVETDDE 1085
            ....|.|.......:||.:|       .:..|.|.|..::|.:|          |..:|:..
Yeast   289 SGGRPKRTIHPPKSKDLFDI-------YENSKPKSKTLQKKFRTCLKILKVLMSKKNSDINF--- 343

  Fly  1086 DMEAEREPTPPPPPPTSKKSKTSKTGKEKEKD---------KEKEKDKDKEKDKETSSF------ 1135
                   |...|..|.:..........:...|         ..|.|..|:..|.....|
Yeast   344 -------PFLQPVDPIALNLPNYFDVVKNPMDLGTISNNLMNWKYKTIDQFVDDLNLVFYNCFQF 401

  Fly  1136 -KRGRKTKSDKSASKSSKKTKK-----------GAKKSSADSDPESDP-SDSRESEDYSDDDHIS 1187
             ..|.:..|      ..||.|:           ...:...|||.|.|. |.|..|:|..||:.|:
Yeast   402 NPEGNEVHS------MGKKLKELFNFHWLENQDILNEIETDSDLEEDNYSSSYSSDDEYDDEDIN 460

  Fly  1188 LAKTKSLVKPTARTIAAQKKK------SVPAESKVKMPTPVKRQVKGKGKGGRKAKDDSLDSDQS 1246
               ...:..|..:.:..:.||      .:..:...|:....||:..||....|||...|:|..:.
Yeast   461 ---ENDITNPAIQYLEQKLKKMEVELQQLKRQELSKLSKERKRKHLGKTLLRRKAMKHSVDDLKK 522

  Fly  1247 DVNVKKQLPPTAAAALAESAAELEED------PDDPPPDE----DEDEDSSRSRSMSPFKVDLHK 1301
            .:..|           ....::||.:      .:..|.||    :|||          .::||
Yeast   523 SITDK-----------INELSDLEMNGMIRIIKNSLPADEILTSNEDE----------IEIDL-- 564

  Fly  1302 KYSKSALNDDLSELLTTVKKVPTAETTKLSARHQDEADEERSSRESDGDFKSLSNSRGSSEERPP 1366
                    |.|.|          |...::..|:.::.:...|.|:..|::.:
Yeast   565 --------DILDE----------ATIARIYERYFEKKNNNNSKRKLSGNYST------------- 598

  Fly  1367 VAKKGKKAESSKKEKEKKGRDKDRDRDKEKDKDKSRSAKDKKSKD 1411
                   |.::||:|..|..:||...:.....|....:.|....|
Yeast   599 -------APTNKKKKTLKFLEKDEIINNNNYSDSEEDSSDSSDSD 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246
dikar	NP_001261480.1	Bromo_gcn5_like	892..991	CDD:99941	38/127 (30%)
BDF2	NP_010213.1	COG5076	55..378	CDD:227408	83/377 (22%)
		Bromodomain	<344..419	CDD:413371	14/80 (18%)
		Lebercilin	<472..>537	CDD:406132	15/75 (20%)
		BET	521..576	CDD:407211	15/95 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900