DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dikar and RSC2

DIOPT Version :9

Sequence 1:	NP_001261480.1	Gene:	dikar / 38747	FlyBaseID:	FBgn0261934	Length:	3261	Species:	Drosophila melanogaster
Sequence 2:	NP_013461.1	Gene:	RSC2 / 851071	SGDID:	S000004349	Length:	889	Species:	Saccharomyces cerevisiae

Alignment Length:	1117	Identity:	185/1117 - (16%)
Similarity:	345/1117 - (30%)	Gaps:	369/1117 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   550 LSPEDKENFCRQLQLLDTNSAAI---------AVATSIADLSLP-SPVAHESETEQDEQVDQPAV 604
            :.|:|..|...|      ||:|:         ::.|...|..|. ||:.:....::| ..|..||
Yeast     1 MMPDDNSNSSTQ------NSSALYKDLRKEYESLFTLKEDSGLEISPIFNVLPPKKD-YPDYYAV 58

  Fly   605 V---------EAQPPALTSAMAPAAN-VKLP-GRQTNNSLSS------------LTGNIFIPSGS 646
            :         :.:.|..|.|.....: |::| ..:|.|:..|            |...|:   .:
Yeast    59 IKNPVSFNTLKKRIPHYTDAQQFMNDVVQIPWNAKTYNTRDSGIYKYALVLEKYLKDTIY---PN 120

  Fly   647 AQQQQQQSQEPPSSSSSSQSGTTTTASTVRSKKQK-AVLNSSGSSSTSKM-ADKADRNLSKTETT 709
            .:::..|...|.......:.|.......:|.|.:: |..|::.:.|:|.| :.:|.|.|.||.|:
Yeast   121 LKEKYPQLVYPDLGPLPDEPGYEEFQQKLREKAEEVARANAARAESSSSMNSTEAARRLRKTRTS 185

  Fly   710 GKSKKSAAGSSASSSSSKAERISGAYSDKSGDDHVNSSNRSTTNNNSS---------LNNNNNHK 765
            .| ::|..|                 :|.:.|:...:::....|...:         |.|.|.:.
Yeast   186 VK-RESEPG-----------------TDTNNDEDYEATDMDIDNPKDADFPDLIRKPLININPYT 232

  Fly   766 HAPHHSHNNNNNSHSTTTSATTTATTTTSQGYHYNSNLNHNQNHQNSHSHHTHHHHHHHHHTTNN 830
            ..|...:.:...|||.|....
Yeast   233 RKPLRDNRSTTPSHSGTPQPL-------------------------------------------- 253

  Fly   831 HSNKHKTKSHHSLAHNNNNNNSPTTNPTSTSLLHPVTTNNNSTYNSSNHANILSFTETEEVLQIG 895
             ..:|:..|.                 |......|...:........|...:|.    :|||..|
Yeast   254 -GPRHRQVSR-----------------TQVKRGRPPIIDLPYIQRMKNVMKVLK----KEVLDSG 296

  Fly   896 MHKVLVYVK---NHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFR 957
            :....::.:   .||||             .||.:|..|:.|..:..|:.:..|..|.||:|||.
Yeast   297 IGLTDLFERLPDRHRDA-------------NYYIMIANPISLQDINKKVKTRRYKTFQEFQNDFN 348

  Fly   958 LIVNNCRLYNGHNNEYTEMVNNLQDAFEKATKKYFDNLSDDEDDDP--NLSYPAADSKMNVFREK 1020
            |::.|.|:.:..:.|..::.|.|:..|....:  |:....|....|  .|.||..:..:|.. ..
Yeast   349 LMLTNFRISHRGDPESIKISNILEKTFTSLAR--FELSKPDRSFIPEGELRYPLDEVIVNNI-SY 410

  Fly  1021 YFSKKAKEETEKDAPGRPAVSSAEEDLSEIEAEAPQKAQKRKRKEKDKR---------RKKKTKS 1076
            :....|....:.| |.:|.|...                .|..|..|.:         |.::|..
Yeast   411 HVGDWALLRNQND-PQKPIVGQI----------------FRLWKTPDGKQWLNACWYYRPEQTVH 458

  Fly  1077 KADVETDDEDMEAEREPTPPPPPPTSKKSKTSKTGKEKE----------------KDKEKEKDKD 1125
            :.|                    ....|::..|||:.::                :.:....|..
Yeast   459 RVD--------------------RLFYKNEVMKTGQYRDHLVSNLVGKCYVIHFTRYQRGNPDMK 503

  Fly  1126 KEKDKETSSFKRGRKTKSDKSASKSSKKTKKGAKKSSADSDPESDPSDSRESEDYSDDDHISLAK 1190
            .|.......|   |..:|||..:|.  :|.|...           |.:.|:.::
Yeast   504 LEGPLFVCEF---RYNESDKIFNKI--RTWKACL-----------PEEIRDLDE----------- 541

  Fly  1191 TKSLVKPTARTIAAQKKKSVPAESK--VKMPTPVKRQVKGKGKGGRKAKDDSLDSDQSDVNVKKQ 1253
                             .::|...:  .|.|:|::..:........:..:.::.|..:
Yeast   542 -----------------ATIPVNGRKFFKYPSPIRHLLPANATPHDRVPEPTMGSPDA------- 582

  Fly  1254 LPPTAAAALAESAAELEE-----DPDDPP-----PDEDEDEDSSRSRSMSPFKVDLHKKYSKSAL 1308
             ||...|.......:.::     ..||.|     |::..:|.          :||:
Yeast   583 -PPLVGAVYMRPKMQRDDLGEYATSDDCPRYIIRPNDSPEEG----------QVDI--------- 627

  Fly  1309 NDDLSELLTTVKKVPTAETTKLSARHQDEADEERSSRESDGDFKSLSNSRGSSEERPPVAKKGK- 1372
                 |..|.....|||.....:.....:....|.:|.|    .||.|.....:::.|:::.|.
Yeast   628 -----ETGTITTNTPTANALPKTGYSSSKLSSLRYNRSS----MSLENQNAIGQQQIPLSRVGSP 683

  Fly  1373 ------KAESSKKEKEKKGRDKDRDRDKEKDKDKSRSAKDKKSKDESPVLVAAAEAAA------- 1424
                  ..:..|:.:.::.:.:.....::|        :.:.|:...|.::....:.|
Yeast   684 GAGGPLTVQGLKQHQLQRLQQQQHQYQQQK--------RSQASRYNIPTIIDDLTSQASRGNLGN 740

  Fly  1425 -VVQAELDMLLPFMDKYDVIKYRRSRAAFSGSSASNSLAPSEDSKSAITKSNRENRKASAKRE-- 1486
             ::.|....:||.....:|...:|:                 |..|...:|.||......|.:
Yeast   741 IMIDAASSFVLPISITKNVDVLQRT-----------------DLHSQTKRSGREEMFPWKKTKGE 788

  Fly  1487 ----KSPDAVENKRGRKSKDQKRSKESDKAEKSDKASKADTEKHSE-----KSKKKEE---PPKV 1539
                :.|..:.|:|...|.|...|...::...::|..|.:.|:..|     ..|.|::   .|.|
Yeast   789 ILWFRGPSVIVNERIINSGDPHLSLPLNRWFTTNKKRKLEYEEVEETMEDVTGKDKDDDGLEPDV 853

  Fly  1540 VEKAQREKSPAP 1551
              :.::|..|.|
Yeast   854 --ENEKESLPGP 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246
dikar	NP_001261480.1	Bromo_gcn5_like	892..991	CDD:99941	26/101 (26%)
RSC2	NP_013461.1	Bromo_Rsc1_2_I	17..121	CDD:99952	19/107 (18%)
RSC2	NP_013461.1	COG5076	123..503	CDD:227408	87/516 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900