DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dikar and BRD3

DIOPT Version :9

Sequence 1:	NP_001261480.1	Gene:	dikar / 38747	FlyBaseID:	FBgn0261934	Length:	3261	Species:	Drosophila melanogaster
Sequence 2:	NP_031397.1	Gene:	BRD3 / 8019	HGNCID:	1104	Length:	726	Species:	Homo sapiens

Alignment Length:	881	Identity:	193/881 - (21%)
Similarity:	296/881 - (33%)	Gaps:	289/881 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   900 LVYVKN--------HRDAWPFVDPVE--EDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRN 954
            |.|::|        |:.||||..||:  :...|.|:.||:.|||:..::.:|::..|...||...
Human    39 LQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQ 103

  Fly   955 DFRLIVNNCRLYNGHNNEYTEMVNNLQDAF------------------------------EKATK 989
            ||..:..||.:||...::...|...|:..|                              :.|..
Human   104 DFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGT 168

  Fly   990 KYFDNLSDDEDDDPNLSYPAADSKMNVFREKYFSKKAKEETEKDAPGRPAVSSAEEDLSEIEAEA 1054
            :....:|......|..|.|...|:..|.............|....|...|.......:..:....
Human   169 QQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPT 233

  Fly  1055 PQKAQKRKRKEKDKRRKKKTKSKADVETDDED-MEAEREPTPPP--PPPTSKKSKTSKTGKEKEK 1116
            |...           :||..|.|||..|.... :.|.|..:|||  .|..:|.....::|....|
Human   234 PPVV-----------KKKGVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIK 287

  Fly  1117 DKEKEKDKDKEKDKETSSFKRGRKTK-SDKSASKSSKKTKKGAKKSSADSDPESDPSDSRESEDY 1180
            ..:|:.: |.|..:..     |:|.| |:......|...:..:||.:|.:.|...|.|:...|.:
Human   288 PPKKDLE-DGEVPQHA-----GKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELH 346

  Fly  1181 SDDDHISLAKTKSLVK--------PTARTIAAQ--------KKKSVPAESKVKMPTPVKRQVKGK 1229
            ...|.|......|.||        |.|:..||.        .|.:.|....|.|
Human   347 DYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAM----------- 400

  Fly  1230 GKGGRKAKD--DSLDSDQSDVNVKKQLPPTAAAAL----AESAAELEEDPDDPPPDEDEDEDSSR 1288
               .||.:|  :...:...|..|:....|..||.:    |||:...||...|....:.|:|.::|
Human   401 ---ARKLQDVFEMRFAKMPDEPVEAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATR 462

  Fly  1289 SRSMSPFKVDLHKKYSKSALNDDLSELLTTVKKVPTAETTKLSARHQDEADEERSSRESDGDFKS 1353
                                   |:||...:|.|           |:..|              :
Human   463 -----------------------LAELQEQLKAV-----------HEQLA--------------A 479

  Fly  1354 LSNSRGSSEERPPVAKKGKKAESSKKEKEKKGRDKDRDRDKEKDKDKSRSAKDKKSKDESPVLVA 1418
            ||.:        ||.|..||.|  |||||||.:||    :|||:|.|.::.::||:|...|
Human   480 LSQA--------PVNKPKKKKE--KKEKEKKKKDK----EKEKEKHKVKAEEEKKAKVAPP---- 526

  Fly  1419 AAEAAAVVQAELDMLLPFMDKYDVIKYRRSRAAFSGSSASNSLAPSEDSKSAITKSNRENRKASA 1483
                                               ...|....||::.:.|. |.:.|:.:|...
Human   527 -----------------------------------AKQAQQKKAPAKKANST-TTAGRQLKKGGK 555

  Fly  1484 KREKSPDAVENKRG-RKSKDQKRSKESDKAEKSDKASKADTEK-----HSEKSKKKEEPPKVVEK 1542
            :...|.|:.|.:.| ..|.|:||....|       .::...||     |..:|:         |.
Human   556 QASASYDSEEEEEGLPMSYDEKRQLSLD-------INRLPGEKLGRVVHIIQSR---------EP 604

  Fly  1543 AQREKSPAPVSA-LETIKEPPAPTPIAT-----------------SASGKVKEGPAKKEPKKRPD 1589
            :.|:.:|..:.. .||:|    ||.:..                 |||||.:...:|:|..:...
Human   605 SLRDSNPDEIEIDFETLK----PTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKK 665

  Fly  1590 KQMPPPPKPADKSSEKGSGKKSSSKKAAQKAGQPQTNNNTNLEALDVETEQTLKDINRWLEHTPR 1654
            |::       :|..:..||:.|||||.|:|. :|.
Human   666 KEL-------EKRLQDVSGQLSSSKKPARKE-KPG------------------------------ 692

  Fly  1655 FTEFSSASNSPSRYNLLDDFDSG----IGSKLDAAD 1686
                |:.|..|||.:.....:||    .||..|::|
Human   693 ----SAPSGGPSRLSSSSSSESGSSSSSGSSSDSSD 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246
dikar	NP_001261480.1	Bromo_gcn5_like	892..991	CDD:99941	31/130 (24%)
BRD3	NP_031397.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		Bromo_Brdt_I_like	34..140	CDD:99929	30/100 (30%)
		Acetylated histone H3 binding. /evidence=ECO:0000269\|PubMed:27105114	78..80		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..169		1/19 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..305		20/84 (24%)
		Bromo_Brdt_II_like	311..412	CDD:99930	24/114 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..462		11/40 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..575		39/165 (24%)
		BET	571..635	CDD:293640	17/83 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	637..726		30/130 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900