DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dikar and cecr2

DIOPT Version :9

Sequence 1:	NP_001261480.1	Gene:	dikar / 38747	FlyBaseID:	FBgn0261934	Length:	3261	Species:	Drosophila melanogaster
Sequence 2:	XP_005174419.1	Gene:	cecr2 / 799918	ZFINID:	ZDB-GENE-131121-533	Length:	1502	Species:	Danio rerio

Alignment Length:	2465	Identity:	443/2465 - (17%)
Similarity:	688/2465 - (27%)	Gaps:	1091/2465 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DIQSWWEIPCISHFCSLFSSAFDLPDIDIEDLESALLSDGTSDEDQVALVPELIVRLLKGCDALQ 74
            :||||||:|.|:||||||.:||:|||.:||:||.|||.   .|:|.:::   |:..|||||
Zfish    11 EIQSWWEVPAIAHFCSLFRTAFNLPDFEIEELEQALLK---QDQDFLSV---LLCSLLKGC---- 65

  Fly    75 TVAKEITHSNYQMFLRRFLRQQCRLHQTENHFDTDIDFQSLPVRKRLHILHDLCHFRLDSVDVQV 139
            ....:||..::..:|...:..:..|.:.:.:...:..|:.||.|.::.:||.||.:|||:.||..
Zfish    66 YQRSDITIQSFSGYLEDIINYRWELEEGKPNPLKEHPFEELPTRTQVELLHRLCDYRLDAADVFD 130

  Fly   140 ILSNLEADSLRVEPLGYDAKNSGYWYFYGTRLYREDKATGGSASSSSGSGSGGAGASTGGASNSK 204
            .|..|::|||||||||.|...:.||||||||||:|:.....|...|:...|..........:..:
Zfish   131 RLKGLDSDSLRVEPLGQDGNGALYWYFYGTRLYKEEPVEVVSPQYSNDKASEKKRRGRPPKNKPE 195

  Fly   205 GI-------GSNGT-------------------VWQVICFTEEDWQNLAAKFKTSTNAKERELFN 243
            .|       |.|..                   .|.|||.|||.|.|||...|...:.::|.|..
Zfish   196 DIDLSVVEEGVNSVKEEYERVEETKPAIERERGAWSVICETEEQWLNLAESIKDKISPQDRHLHR 260

  Fly   244 ILDDNFLPKLPQLFRERERLRRRKLLQVRNSSRIRNIAELKARQEEERQRRERENLYQDRQNAHW 308
            |:..||||::..:...:|:..::|||.
Zfish   261 IITQNFLPEISNMIEHKEKELKQKLLN-------------------------------------- 287

  Fly   309 LAPPQQQQQQQQQQQQQQQQSQQRTRRRSQSTSTASGISTYASSLRRTTTTNSSEFLCHRETFCL 373
             :|.:...|.:|...:...|.|..|
Zfish   288 -SPKEHNSQSEQHSSKDNWQMQATT---------------------------------------- 311

  Fly   374 SPENDEDDDDDDEALDAEQQSDQPEQQRQQEEQPPEEEQRQEPEELLAVSATDDDFRSPEAPKSQ 438
                 |::...||  |.|:|....||:::.|....||.:|:|.|.:.||
Zfish   312 -----EEERQRDE--DLERQVLLAEQRKEDERLLQEEREREEQERVKAV---------------- 353

  Fly   439 TPAELKSKSSHHHHHHHHKKKKSSKKQKKRHHRDKGRERDREHHHHHRRRHKHASEADEGEDDNN 503

Zfish   354 ----------------------------------------------------------------- 353

  Fly   504 NHNSNSNSNSNTNSISSNNSVQPKRRRSGQQQQHHQQAETTEPSTSLSPEDKENFCRQLQLLDTN 568
                                    ..|:.:::|..::|........|.||
Zfish   354 ------------------------EERARRRKQREEKAWLLSQGKELPPE--------------- 379

  Fly   569 SAAIAVATSIADLSLPSPVAHESETEQDEQVDQPAVVEAQPPALTSAMAPAANVKLPGRQTNNSL 633
                     :.:|...||:.....|:|..::|
Zfish   380 ---------LLNLETHSPIRRARRTKQFYEID--------------------------------- 402

  Fly   634 SSLTGNIFIPSGSAQQQQQQSQEPPSSSSSSQSGTTTTASTVRSKKQKAVLNSSGSSSTSKMADK 698

Zfish   403 ----------------------------------------------------------------- 402

  Fly   699 ADRNLSKTETTGKSKKSAAGSSASSSSSKAERISGAYSDKSGDDHVNSSNRSTTNNNSSLNNNNN 763
                                                      ||:.
Zfish   403 ------------------------------------------DDYT------------------- 406

  Fly   764 HKHAPHHSHNNNNNSHSTTTSATTTATTTTSQGYHYNSNLNHNQNHQNSHSHHTHHHHHHHHHTT 828

Zfish   407 ----------------------------------------------------------------- 406

  Fly   829 NNHSNKHKTKSHHSLAHNNNNNNSPTTNPTSTSLLHPVTTNNNSTYNSSNHANILSFTETEEVLQ 893

Zfish   407 ----------------------------------------------------------------- 406

  Fly   894 IGMHKVLVYVKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRL 958
             .::|||..:|.|:|||||::||:|..||.|:.||:.||||..:|.||:.|||....||..|.:|
Zfish   407 -ALYKVLEALKAHKDAWPFMEPVDESYAPNYHEIIQTPMDLSTIERKLNDGEYLAKDEFVADVKL 470

  Fly   959 IVNNCRLYNGHNNEYTEMVNNLQDAFEKATKKYFDNLSDDEDDDPNLSYPAADSKMNVFREKYFS 1023
            :..||..|||..:|||.|..:|:..|.:|..|:|.  |:|.|.|......:.|.|         .
Zfish   471 MFGNCLEYNGEESEYTIMAESLERCFTRALLKHFP--SEDGDTDEEFHVSSEDRK---------D 524

  Fly  1024 KKAKEETEKDAPGRPAVSSAEEDLSEIEAEAPQKAQKRKRKEKDK-RRKKKTKSKADVETDDEDM 1087
            ||..:..::..|             |....|.::.||||.....| ..:::.|.|:.::
Zfish   525 KKKNKNHKQSGP-------------ESLIRATEQVQKRKTSNSGKGNNQQQEKPKSTLQ------ 570

  Fly  1088 EAEREPTPPPP-----PPTSKKSKTSKTGKEKEKDKEKEKDKDKEKDKETSSFKRGRKTKSDKSA 1147
                   ||||     ||   .......|::                      :||..    ..|
Zfish   571 -------PPPPHYSNGPP---HPHNIHPGQQ----------------------QRGML----HPA 599

  Fly  1148 SKSSKKTKKG--AKKSSADSD---PESDPSDSRESEDYSDD---------DHIS--LAKTKSLVK 1196
            .:..:.:..|  |:....|:.   |...|..||...|:.:.         .||:  ...|:..|.
Zfish   600 QQFQRPSGPGMYAQHMMIDAQYPYPGQRPLISRPPGDHENQHVPHFNMQGSHINGPHLGTRYTVG 664

  Fly  1197 PTARTIA---AQKKKSVPAESKVKMPTPVKRQVKGKGKGGRKAKDDSLDSDQSDVNVKKQLPPTA 1258
            |..:.:.   .|...|.|.......|.|:..|..|            |.|
Zfish   665 PDGQPLQPPHQQHSYSGPTHGPSLGPRPMALQPGG------------LCS--------------- 702

  Fly  1259 AAALAESAAELEEDPDDPPPDED--EDEDSSRSRSMSPF-------KVDLHKK---YSKSALNDD 1311
                             |||:.:  ........:||.|.       .|.:|..   |....:|..
Zfish   703 -----------------PPPEGNMYPSHQHPEGQSMRPMGNAYTRPGVPMHSSYPPYGPHGMNIP 750

  Fly  1312 LSELLTTVKKVPT-----AETTKLSARHQDEADEERSSRE-----SDGDFKSLS-NSRGSSEERP 1365
            ........::.||     .:....|.:|....:...|...     ::|.||..| ||:|
Zfish   751 RMWPPMNHQRQPTPSGNMMQEPSASGQHPYNHNMIHSQNSTGFTMANGQFKMPSANSQG------ 809

  Fly  1366 PVAKK---GKKAESSKKEKEKKGRDKDRDRDKEKDKDKSRSAKDKKSKDESPVLVAAAEAAAVVQ 1427
            ||.:|   |.:|                            |.....|..:||.::|..:.:|
Zfish   810 PVGQKLQGGPQA----------------------------SRLHLASMLDSPEMIALQQLSA--- 843

  Fly  1428 AELDMLLPFMDKYDVIKYRRSRAAFSGSSASNSLAPSEDSKSAITKSNRENRKASAKREKSPDAV 1492
                     ...:.|..::..:     .|..|.||.:|.|                    ||
Zfish   844 ---------SSSHHVGNFQSPQ-----QSGGNPLASAEQS--------------------SP--- 871

  Fly  1493 ENKRGRKSKDQKRSKESDKAEKSDKASKADTEKHSEKSKKKEEPPKVVEKAQREKSPAPVSALET 1557
            |.:....|:|::.:..|.|.......:|..|.:.|....:....|...||:::   |:.|:.|.:
Zfish   872 EKQLHMPSRDKQHTPVSSKGSSPKSGNKMSTGEISLTEAESRSYPSTTEKSEQ---PSQVTGLAS 933

  Fly  1558 IKEPPAPTPIATSASGKVKEGPAKKEPKKRPDKQMPPPPKPADKSSEKGSGKKSSSKKAAQKAGQ 1622
            :..|                   .||..:..||             .:.|..:....:...:.|.
Zfish   934 VSSP-------------------SKELNQNEDK-------------HRLSNLEKIHDQLNSQLGP 966

  Fly  1623 PQTNNNTNLEALDVETEQTLKDINRWLEHTPRFTEFSSASNSPS--RYNLLDDFDSGIGSKLDAA 1685
            |      ||:::|                     .||...|||.  .:...||....|..:::..
Zfish   967 P------NLKSVD---------------------GFSFPLNSPQPMPHKTQDDIPLNISQQINKH 1004

  Fly  1686 DFRRPVALAAPK-AELVPTKLAEALNELVSEPK-EAVSKSESESVAPTPSSVSSSCGTPPHSMHS 1748
            ...:.:...:.: ::.||.::.:.:.:.::|.. ....:|.|:.:....|......| |.|.|..
Zfish  1005 ALPQIIQNGSQRQSQNVPPQILQNIPQQMTENVIHQYHQSVSQQIQNNESVRGPQVG-PLHGMPQ 1068

  Fly  1749 GNSIGSTSATAASSSNCSNNSMPTPLPVAVTPTPTPAPPPLLPIPKPKEPSTTQLILNPPPPPHI 1813
            .:|.|..                   |....|....:.||..|:..|        :..|.|....
Zfish  1069 ISSQGGQ-------------------PGVHQPATLSSLPPSHPVSHP--------LAQPSPADQG 1106

  Fly  1814 KQQLAKEAKRKSLKEKQAAQAAQAQQVKAKANVMRTIDRLQPGKAKGNLLQNVVAVKSTEEGGDS 1878
            .|:..:...||      .:..:.|.|..:.||
Zfish  1107 DQRPCEPTSRK------VSDGSTASQDGSNAN--------------------------------- 1132

  Fly  1879 HAGVNPVTTKVKELKNALITETCEGAPKLSLGTVLKTQDFSLGKSLEEMSGKKDANEDDRP---- 1939
                             |.|:...|.        .|.|.||               .:.:|
Zfish  1133 -----------------LRTDCTSGQ--------YKQQPFS---------------PESKPPLVR 1157

  Fly  1940 NEEASPKNSSPPTTPNTEAPKPFEALHELSKRGKSSEPSKSEASQKEKPNLSAWLKAFGGPKVSK 2004
            .|:|..:|.:|||  :::.|:.....|.     ..|||    |.|...|:       .|.|..:.
Zfish  1158 QEQAPLQNQTPPT--HSQGPESNNVTHY-----GISEP----AHQPFGPH-------HGRPLQTS 1204

  Fly  2005 KSEDEEKQQTPVQDLQGDSKVAPPAHSPAGDNFSLPTVMRQRKPSTGSTNSERSSFSQDPDSPRI 2069
            ..:....|..|..:...:..   |||.||   |...::..|.:.:|..:....|...|.....:.
Zfish  1205 NHQSYTSQGLPSHENNPNQN---PAHYPA---FHQQSIQYQYRMATQHSQGHPSMHPQFQQQQQF 1263

  Fly  2070 AIDERYGSYAAGSYTSPIGASPIGASPIMVSPKPNDDMGKPASPYPLNGAIKVGFYQDTTTKSSP 2134
            ...:|:|                  .|:.    |.::.  |..||
Zfish  1264 YQQQRHG------------------RPVF----PTEEW--PRHPY-------------------- 1284

  Fly  2135 DKSCSPRE--MNSPYPQYSQHIYSSASSPNVSTPDMSGTSPYGGGNSYN--------PSGSEASK 2189
                .|:.  |::.||..|...::...:.|       |.||:|...|..        |.||.:|.
Zfish  1285 ----QPQHPVMSNSYPTPSAGSFNGRHNDN-------GMSPHGSDGSVGSLMSPNLLPDGSHSSS 1338

  Fly  2190 TPAYSSTSPLPIYDQYKQPRSQESDYNSSMSP----------STPNPHSPYQQPQSSPY----TT 2240
            .......||.      ||.|::|....|. ||          :|...|:..|...|.||    ..
Zfish  1339 FENKEDGSPA------KQARTEEPSERSE-SPKEILDLDSHNATARHHTSAQPHSSFPYGPRGMH 1396

  Fly  2241 PQQSQSTHPSPYHNQS-PYHQQQHSPYH-PPAAQQQQQSSQPSHSPAAHQQALSPMHSVESPASS 2303
            |...||..|.|:...| ||..||.|..| .|      |:..|              |.:|
Zfish  1397 PSMQQSAAPPPHMMASGPYSSQQFSGGHFAP------QNPHP--------------HLME----- 1436

  Fly  2304 AATQPPTPLAQSPAEQQHSPYQQPVLSPYQQPQQQVQPPVVPPVQPSAGAQASTALGNNG 2363
             |.|.|..|..||.:.:.:.|:.|.::.:.|.....|..||......:|.|.......||
Zfish  1437 -ALQRPQHLPFSPGQSRMTMYRHPNVAGHFQGMMVPQRAVVAEHLFRSGHQMLRTASPNG 1495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246	15/47 (32%)
dikar	NP_001261480.1	Bromo_gcn5_like	892..991	CDD:99941	44/98 (45%)
cecr2	XP_005174419.1	DDT	23..63	CDD:280886	22/45 (49%)
		ARGLU	202..366	CDD:291991	49/354 (14%)
		Bromo_gcn5_like	403..503	CDD:99941	46/249 (18%)
		Med15	675..>1110	CDD:255446	105/642 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I8014
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	350	1.000	Inparanoid score	I2248
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007388
OrthoInspector	1	1.000	-	-		oto41574
orthoMCL	1	0.900	-	-		OOG6_106343
Panther	1	1.100	-	-	LDO	PTHR14296
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5612
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.980