DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dikar and Brd3

DIOPT Version :9

Sequence 1:	NP_001261480.1	Gene:	dikar / 38747	FlyBaseID:	FBgn0261934	Length:	3261	Species:	Drosophila melanogaster
Sequence 2:	NP_001107046.1	Gene:	Brd3 / 67382	MGIID:	1914632	Length:	743	Species:	Mus musculus

Alignment Length:	910	Identity:	204/910 - (22%)
Similarity:	318/910 - (34%)	Gaps:	250/910 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   852 SPTTNPTSTSLLHPVTTNNNSTYNSSNHANILSFTETEEVLQIGMHKVLVYVK---NHRDAWPFV 913
            :||..|.....::|.....::........|.|.:.:.            |.||   .|:.||||.
Mouse     7 APTGIPAVPGPVNPPPPEVSNPSKPGRKTNQLQYMQN------------VVVKTLWKHQFAWPFY 59

  Fly   914 DPVE--EDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEM 976
            .||:  :...|.|:.||:.|||:..::.:|::..|...||...||..:..||.:||...::...|
Mouse    60 QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLM 124

  Fly   977 VNNLQDAF------------------------------EKATKKYFDNLSDDEDDDPNLSYPAAD 1011
            ...|:..|                              :.|..:....:|......|..:.|...
Mouse   125 AQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQNAGSQQVAAVSSVSPATPFQNIPPTV 189

  Fly  1012 SKMNVFREKYFSKKAKEETEKDAPGRPAVSSAEEDLSEIEAEAPQKAQKRKRKEKDKRRKKKTKS 1076
            |:..|.............|....|...|.......:..:....|...           :||..|.
Mouse   190 SQTPVIAATPVPTITANVTSVPVPPPAAPPPPATPIVPVVPPTPPVV-----------KKKGVKR 243

  Fly  1077 KADVETDDED-MEAEREPTPPP--PPPTSKKSKTSKTGKEKEKDKEKEKDKDKEKDKETSSFKRG 1138
            |||..|.... :.|.|..:|||  .|..:|.....::|....|..:|:.: |.|..:..     |
Mouse   244 KADTTTPTTSAITASRSESPPPLSEPKQAKVVARRESGGRPIKPPKKDLE-DGEVPQHA-----G 302

  Fly  1139 RKTK-SDKSASKSSKKTKKGAKKSSADSDPESDPSDSR--ESEDYSD----DDHISLAKTK--SL 1194
            :|.| |:......|...:..:||.:|.:.|...|.|:.  |..||.|    ...:|..|.|  |.
Mouse   303 KKGKLSEHLRHCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDSR 367

  Fly  1195 VKPTARTIAAQ--------KKKSVPAESKVKMPTPVKRQVKGKGKGGRKAKD--DSLDSDQSDVN 1249
            ..|.|:..||.        .|.:.|....|.|              .||.:|  :...:...|..
Mouse   368 EYPDAQGFAADIRLMFSNCYKYNPPDHEVVAM--------------ARKLQDVFEMRFAKMPDEP 418

  Fly  1250 VKKQLPPTAAAAL----AESAAELEEDPDDPPPDEDEDEDSSRSRSMSPFKVDLHKKYSKSALND 1310
            ::....|...|.:    |||:...||...|....:.|:|.::|       ..:|.::....|..|
Mouse   419 MEAPALPAPTAPIVSKGAESSRSSEESSSDSGSSDSEEERATR-------LAELQEQTGCGAFQD 476

  Fly  1311 DLSELLTTVKKVPTAETTKLSARHQDEADEERSSRESDGDFKSLSNSRGSSEERPPVAKKGKKAE 1375
            .|..:          .:.:|.|.|:..|              :||.:        ||.|..||.|
Mouse   477 QLLNV----------SSVQLKAVHEQLA--------------ALSQA--------PVNKPKKKKE 509

  Fly  1376 SSKKEKEKKGRDKDRDRDKEKDKDKSRSAKDKKSKDESPVLVAAAEAAAVVQAELDMLLPFMDKY 1440
              |||||||  .||:|:||||:|.|::|.::||:|        ||.||
Mouse   510 --KKEKEKK--KKDKDKDKEKEKHKAKSEEEKKAK--------AAPAA----------------- 545

  Fly  1441 DVIKYRRSRAAFSGSSASNSLAPSEDSKSAITKSNRENRKASAKREKSPDAVENKRG-RKSKDQK 1504
                          ..|....||::.:.|..|.| |:.:|...:...|.|:.|.:.| ..|.|:|
Mouse   546 --------------KQAQQKKAPTKKANSTTTAS-RQLKKGGKQASASYDSEEEEEGLPMSYDEK 595

  Fly  1505 RSKESDKAEKSDKASKADTEK-----HSEKSKKKEEPPKVVEKAQREKSPAPVSA-LETIKEPPA 1563
            |....|       .::...||     |..:|:         |.:.|:.:|..:.. .||:|
Mouse   596 RQLSLD-------INRLPGEKLGRVVHIIQSR---------EPSLRDSNPDEIEIDFETLK---- 640

  Fly  1564 PTPIATSASGKVKEGPAKKEPKKRPDKQMPPPPKPADKSSEKGSGKKSSSKKAAQKAGQPQTNNN 1628
            ||.: ......||....||:            .||...     ||||.::|...:.|.:.:.
Mouse   641 PTTL-RELERYVKSCLQKKQ------------RKPLST-----SGKKQAAKSKEELAQEKKK--- 684

  Fly  1629 TNLEALDVETEQTLKDINRWL---EHTPRFTEFSSASNSPSRYNLLDDFD----SGIGSKLDAAD 1686
                    |.|:.|:|::..|   :.|.:....|:.|..|||.:.....:    |..||..|::|
Mouse   685 --------ELEKRLQDVSGQLNSKKPTKKEKSGSAPSGGPSRLSSSSSSESASSSSSGSSSDSSD 741

Fly 1687 1686
Mouse 742 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246
dikar	NP_001261480.1	Bromo_gcn5_like	892..991	CDD:99941	31/133 (23%)
Brd3	NP_001107046.1	Bromo_Brdt_I_like	33..139	CDD:99929	32/117 (27%)
		Bromo_Brdt_II_like	310..411	CDD:99930	26/114 (23%)
		BET	589..653	CDD:374956	18/84 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900