DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dikar and Pbrm1

DIOPT Version :9

Sequence 1:	NP_001261480.1	Gene:	dikar / 38747	FlyBaseID:	FBgn0261934	Length:	3261	Species:	Drosophila melanogaster
Sequence 2:	NP_001074720.1	Gene:	Pbrm1 / 66923	MGIID:	1923998	Length:	1704	Species:	Mus musculus

Alignment Length:	1811	Identity:	315/1811 - (17%)
Similarity:	536/1811 - (29%)	Gaps:	671/1811 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   364 FLCHRETFCLSPENDEDDDDDD----------------------EALDAEQQSDQPEQQRQQE-- 404
            :|..|..|....|.|::|||:|                      :.|:|...:..|..:...|
Mouse   144 YLRTRNEFVQKGEADDEDDDEDGQDNQGTLADGSSPGYLKEILEQLLEAIVVATNPSGRLISELF 208

  Fly   405 EQPPEEEQR-------QEPEEL--LAVSATDDDFRSPEAPKSQTPAELKSKSSHHHHHHHHKKKK 460
            ::.|.:.|.       :||.:|  :|....:..::|..|....  .:|.:|::..::....:..|
Mouse   209 QKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKD--IDLLAKNAKTYNEPGSQVFK 271

  Fly   461 SSKKQKKRHHRDKGRERDREHHHHHRR--RHKHASEADEGEDDNNNHNSNS---NSNSNTNSISS 520
            .:...||..:..|.   :.|||...:.  |.:.||..........:||.:|   ..|..:....:
Mouse   272 DANSIKKIFYMKKA---EIEHHEMTKSSLRIRTASNLAAARLTGPSHNKSSLGEERNPTSKYYRN 333

  Fly   521 NNSVQPKRRRSGQQQQHHQQAETTEPSTSLSPEDKENFCRQLQLLDTNSAAIAVATSIADLSLPS 585
            ..:||..|                                        .:||.:|
Mouse   334 KRAVQGGR----------------------------------------LSAITMA---------- 348

  Fly   586 PVAHESETEQDEQVDQPAVVEAQPPA--LTSAMAPAANVKLPGRQTNNSLSSLTGN--------- 639
             :.:.||:|:|..:......|.:..|  :||.|    :|..|..|..:::.|...:
Mouse   349 -LQYGSESEEDAALAAARYEEGESEAESITSFM----DVSNPFHQLYDTVRSCRNHQGQLIAEPF 408

  Fly   640 IFIPSGSAQQQQQQSQEPPSSSSSSQSGTTTTASTVRSKKQKAVLNSSGSSSTSKMADKADR--- 701
            ..:||........|..:.|.|....::         :.|.|:...........:.|.:.|.|
Mouse   409 FHLPSKKKYPDYYQQIKMPISLQQIRT---------KLKNQEYETLDHLECDLNLMFENAKRYNV 464

  Fly   702 -------NLSKTETTGKSKKSAAG------------SSASSSSSKAERISGAY-SDKSGDDHVNS 746
                   .:.|.:...::||....            |||:|.:..|:|....: |:..|...::|
Mouse   465 PNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSS 529

  Fly   747 SNRSTTNNNSSLNN--------------------NNNHKHAPHH-------------SHNNNNNS 778
            ...........|.|                    ..:.|..|.:             .||..|:.
Mouse   530 KKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDK 594

  Fly   779 HSTTTSATTTATTTTSQGYHYNSNLN-HNQNHQNSHSHHTHHHHHHHHHTTNNHSNKHKTKSHHS 842
            ::            ..:|...:..|. .|..|.|......::..|......     |.|.|....
Mouse   595 YA------------GEEGMMEDMKLMFRNARHYNEEGSQVYNDAHILEKLL-----KDKRKELGP 642

  Fly   843 LAHNNNNNNSPT--------TNPTSTSLLHPVTTNNNSTYNSSNHANILSFTETEEVLQIGMHKV 899
            |. ::::..||.        .:|..:..:.|:....|..|.:
Mouse   643 LP-DDDDMASPKLKLSRKSGVSPKKSKYMTPMQQKLNEVYEA----------------------- 683

  Fly   900 LVYVKNHRD------AWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRL 958
               |||:.|      :..|:........|.||..|::|||:.|:...:.:.:|........||.:
Mouse   684 ---VKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVM 745

  Fly   959 IVNNCRLYNGHNNEYTEMVNNLQDAFEKATKKYFDNLSDDEDDD-PNLSYPAADSKMNVFREKYF 1022
            :.||...|    ||...::........|...:...:|..|||.. ||::....:...|:|
Mouse   746 MFNNACTY----NEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLF----- 801

  Fly  1023 SKKAKEETEKDAPGRPAVSSAEEDLSEIEAEAPQKAQK--------RKRKEKDKRR--------- 1070
               ....:.:|..||    ...:.|:||.|..|....|        ||..|.::.|
Mouse   802 ---VSVMSHQDDEGR----CYSDSLAEIPAVDPNSPNKPPLTFDIIRKNVESNRYRRLDLFQEHM 859

  Fly  1071 -----KKKTKSKADVETDDEDMEAE------REP--------TPPPPPPTSK-------KSKTSK 1109
                 :.:..::.|.|..::.:|.:      |:.        ..|....|:|       |.|..|
Mouse   860 FEVLERARRMNRTDSEIYEDAVELQQFFIRIRDELCKNGEILLSPALSYTTKHLHNDVEKEKKEK 924

  Fly  1110 TGKEKEKDKEKEKDKDKEKDK-ETSSFKRG----RKTKSDKSASKSSK----------------- 1152
            ..||.|:||.|.:::.:|.:| |.||...|    .:|.|...:.|:|.
Mouse   925 LPKEIEEDKLKREEEKREAEKSEDSSGTTGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQ 989

  Fly  1153 ---------------------------------KTKKGAKKSSADSD-----PESD--------- 1170
                                             .|:|..:|....||     |.|.
Mouse   990 PHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMF 1054

  Fly  1171 --------PSDSRESEDYSDDDHISLAKTKSLVKPTARTIAAQKKKSVPAESKVKMPTPVKRQVK 1227
                    |.:.|:.:.:..:...| |||||..|....|:.....:.||.:    :|.||.|...
Mouse  1055 VKEYFKLCPENFRDEDVFVCESRYS-AKTKSFKKIKLWTMPISSVRFVPRD----VPLPVVRVAS 1114

  Fly  1228 ---GKGKGGRKAKDDSLDSDQSDVNVKKQLPPTAAAALAESAAELEEDPDDPP------------ 1277
               ...||     ||..::|.||.|            .||....||::.:|.|
Mouse  1115 VFANADKG-----DDEKNTDNSDDN------------RAEDNFNLEKEKEDVPVEMSNGEPGCHY 1162

  Fly  1278 ---------------------------------------------------PDEDEDEDSSRSRS 1291
                                                               |:|.|.|.:.....
Mouse  1163 FEQLRYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYK 1227

  Fly  1292 MSPFKVDLHK---------KYSKSALNDDLSELLTTVKKVPTAETTKLSARHQDEADEERSSRES 1347
            ...|..:|.:         |.:..:..|.||...|   ::|..:.....:|: :|:|::...
Mouse  1228 KEVFLSNLEETCPMSCILGKCAVLSFKDFLSCRPT---EIPENDILLCESRY-NESDKQMKK--- 1285

  Fly  1348 DGDFKSLSNSRGSS------------------EERPPVAKKGKKAESSKKEKEKKGRDKDRDRDK 1394
               ||.|.....|:                  |..|.:.||.:..|:  |..|.:|.|.|.:...
Mouse  1286 ---FKGLKRFSLSAKVVDDEIYYFRKPIIPQKEPSPLLEKKIQLLEA--KFAELEGGDDDIEEMG 1345

  Fly  1395 EKDKDKSRSAKDKKSKDESPVLVAAAEAAAVVQAELDMLLPFMDKYDVIKYRRSRAAFSGSSASN 1459
            |:|.:                   ..||.::.|.:    .|..::.|::.|...::  :..||..
Mouse  1346 EEDSE-------------------VIEAPSLPQLQ----TPLANELDLMPYTPPQS--TPKSAKG 1385

  Fly  1460 SLAPSEDSKSAITKSNR---ENRKASAKREKSPDAVENKRGRKSKDQKRSKE-SDKAEKSDKASK 1520
            | |..|.||..|..|..   .:...:..:.:.||....:..|....:.|:.| :.|||..::|:|
Mouse  1386 S-AKKESSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEERAAK 1449

  Fly  1521 ADTEKHSEKSKKKEEPPKVVEKAQREKSPAPVSALETIKEPPAP--------TPIATSASGKVKE 1577
            ...::..|::.::::|      :...::..||.||..:..||.|        ||:|....|.
Mouse  1450 VAEQQERERAAQQQQP------SASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAGMMGGY--- 1505

  Fly  1578 GPAKKEPKKRPDKQMPPPPKPADKSSEKGSGKKSSSKKAAQKAGQPQTNNNTNLEALDVETEQTL 1642
                       ...:||...|.|.....||
Mouse  1506 -----------PPGLPPLQGPVDGLVSMGS----------------------------------- 1524

  Fly  1643 KDINRWLEHTPRFTEFSSASNSPSRYNLLDDFDSGIGSKLDAADFRRPVALAAPKAELVPTKLAE 1707
                                                         .:|:....|.    |..|..
Mouse  1525 ---------------------------------------------MQPLHPGGPP----PHHLPP 1540

  Fly  1708 ALNELVSEPKEAVSKSESESVAPTPSSVSSSCGTP-PHSMHSGNSIGSTSATAASSSNCSNNSMP 1771
            .:..|...|...|.   ::.|||       ..||| |.....|..:|........:        |
Mouse  1541 GVPGLPGIPPPGVM---NQGVAP-------MVGTPAPGGSPYGQQVGVLGPPGQQA--------P 1587

  Fly  1772 TPLPVAVTPTPTPAPPPLLPIPKPKEPSTTQLILNPPPPPHIKQQLAKEAKRKSLK 1827
            .|.     |.|.||.||::     ::|:|...:   .|||..::.|..||..|.::
Mouse  1588 PPY-----PGPHPAGPPVI-----QQPTTPMFV---APPPKTQRLLHSEAYLKYIE 1630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246
dikar	NP_001261480.1	Bromo_gcn5_like	892..991	CDD:99941	22/104 (21%)
Pbrm1	NP_001074720.1	Bromo_polybromo_I	44..156	CDD:99954	3/11 (27%)
		Bromo_polybromo_II	182..284	CDD:99948	17/103 (17%)
		Bromo_polybromo_III	383..484	CDD:99951	14/109 (13%)
		Bromo_polybromo_IV	534..637	CDD:99949	14/119 (12%)
		Bromo_polybromo_V	673..777	CDD:99946	24/133 (18%)
		Bromo_polybromo_VI	790..897	CDD:99956	19/118 (16%)
		BAH_polybromo	972..1089	CDD:240068	16/117 (14%)
		BAH_polybromo	1170..1288	CDD:240068	16/127 (13%)
		HMG-box	1395..1459	CDD:238037	13/63 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900