DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dikar and brd4

DIOPT Version :9

Sequence 1:NP_001261480.1 Gene:dikar / 38747 FlyBaseID:FBgn0261934 Length:3261 Species:Drosophila melanogaster
Sequence 2:NP_001104751.1 Gene:brd4 / 570531 ZFINID:ZDB-GENE-030131-267 Length:1444 Species:Danio rerio


Alignment Length:2096 Identity:386/2096 - (18%)
Similarity:609/2096 - (29%) Gaps:873/2096 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   842 SLAHNNNNNNSP-TTNPTSTSLLHPVTTNNNSTYNSSNHANILSFTETEEVLQIGMHKVLVYVKN 905
            |.|.::.|.|.| |:|||     .|....|...|                :|::    ||..:..
Zfish    22 SQAPSSFNPNPPETSNPT-----RPKRQTNQLQY----------------LLKV----VLKSLWK 61

  Fly   906 HRDAWPF---VDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYN 967
            |:.||||   ||.|:.:: |.||.||:.|||:..::.:|:|..|....|...||..:..||.:||
Zfish    62 HQFAWPFHAPVDAVKLNL-PDYYKIIKNPMDMGTIKKRLESAFYTSAQECIQDFNTMFTNCYIYN 125

  Fly   968 GHNNEYTEMVNNLQDAFEKATKKYFDNLSDDEDDDPNLSYPAADSKMNVFREKYFSKKAKEETEK 1032
            ...::...|...|                                      ||.|..|..|..::
Zfish   126 KPGDDIVLMAEAL--------------------------------------EKVFLTKISEMPQQ 152

  Fly  1033 DAPGRPAVSSAEEDLSEIEAEAPQKAQKRKRKEKDKRRKKKTKSKADVETDDEDMEAEREPTPPP 1097
            :.              ||...| .|.:.|.|::.|...|                      ..|.
Zfish   153 EV--------------EISTTA-GKGRGRGRRDPDMNMK----------------------VGPV 180

  Fly  1098 PPPTSKKSKTSKTGKEKEKDKEKEKDKDKEKDKETSSFKRGRKTKSDKSASKSSKKTKKGAKKSS 1162
            ..|.:...:|                      :..|:...|.:|:                    
Zfish   181 LEPLTASPQT----------------------RGLSNLTPGPQTR-------------------- 203

  Fly  1163 ADSDPESDPSDSRESEDYSDDDHISLAKTKSLVKPTARTIAAQKKKSVPAESKVKMPTPVKRQVK 1227
              ..|:..|                                     ::|       |.|:     
Zfish   204 --GPPQGPP-------------------------------------TLP-------PQPI----- 217

  Fly  1228 GKGKGGRKAKDDSLDSDQSDVNVKKQLPPTAAAALAESAAELEEDPDDPPPDEDEDEDSSRSRSM 1292
                                |.: :.|||....:|.......   |...||           .|:
Zfish   218 --------------------VQI-QALPPRVPPSLPTIPLHA---PQLGPP-----------FSL 247

  Fly  1293 SPFKVDLHKKYSKSALNDDLSELLTTVKKVPTAETTKLSARHQDEADEERSSRESDGDFKSLSNS 1357
            .|               .|.:.....:..||....|.|                           
Zfish   248 GP---------------TDCNPPAPIITAVPPPTQTAL--------------------------- 270

  Fly  1358 RGSSEERPPVAKKGKKAESSKKEKEKKGRDKDRDRDKEKDKDKSRSAKDKKSKDESPVLVAAAEA 1422
                   |||..:...|                                      .|:|      
Zfish   271 -------PPVHIQQSAA--------------------------------------PPIL------ 284

  Fly  1423 AAVVQAELDMLLPFMDKYDVIKYRRSRAAFSGSSASNSLAPSEDSKSAITKSNRENRKASAKREK 1487
                                                                            :
Zfish   285 ----------------------------------------------------------------Q 285

  Fly  1488 SPDAVENKRGRKSKDQKRSKESDKAEKSDKASKADTEKHSEKSKKKEEPPKVVEKAQREKSPAPV 1552
            :|.::.|||    |.|||              ||||...:...:..|..|               
Zfish   286 TPISIPNKR----KSQKR--------------KADTTTPTANDQLNESSP--------------- 317

  Fly  1553 SALETIKEPPAPTPIATSASGKVKEGPAKKEPKKRPDKQMP--------PPPKPADKSSEK---- 1605
                           |.|.|||.........|.|.|.|:.|        .|..|:.|..|:    
Zfish   318 ---------------AESKSGKTLPRRDNTRPSKLPKKEAPDSQHHWTAAPGTPSPKQQEQLRYC 367

  Fly  1606 -GSGKKSSSKKAAQKAG---QPQTNNNTNLEALDVETEQTLKDINRWLEHTPRFTEFSSASNSPS 1666
             |..|...:||.|..|.   :|          :||:| ..|.|.:..::|             |.
Zfish   368 SGIVKDMFAKKHAAYAWPFYKP----------VDVDT-LGLHDYHDIIKH-------------PM 408

  Fly  1667 RYNLLDDFDSGIGSKLDAADFRRPVALAA--------------PKAELV--PTKLAEALN----E 1711
            ..:.:.|       ||:...:|.....||              |..|:|  ..||.:...    :
Zfish   409 DLSTIKD-------KLETRQYREAQEFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAK 466

  Fly  1712 LVSEPKEAVSKSESESVAPTPSSVSSSCGTPPHSMHSGNSIGSTSATAASSSNCSNNSMPTPLPV 1776
            :..||:|.::.:.:..:.|.|..      |.|           ..|||:||...|::|       
Zfish   467 MPDEPEEMLAPAPAPVLHPAPVK------TQP-----------VMATASSSDTSSDSS------- 507

  Fly  1777 AVTPTPTPAPPPLLPIPKPKEPSTTQLILNPPPPPHIKQQLAKEAKRKSLKEKQAAQAAQAQQVK 1841
                             ...|.||..               ::|.:.:.|.|.|       :|:|
Zfish   508 -----------------SESESSTDD---------------SEEERAQRLAELQ-------EQLK 533

  Fly  1842 AKANVMRTIDRLQPGKAKGNLLQNVVAVKSTEEGGDSH---AGVNPVTTKVKELKNALITETCEG 1903
            |....:..:.:.|..|.|..      ..:..|:..|.|   |||.|...::.|...||   ..:|
Zfish   534 AVHEQLAALSQPQASKPKKK------EKEKKEKKKDKHKKKAGVMPALEEILEPPPAL---KPQG 589

  Fly  1904 APKLSLGTVLKTQDFSLGKSLEEMSGKKDANEDDRPNEEASPKNSSPPTTPNTEAPKP-FEALHE 1967
            .|        |.:|     .|.:.|.|....|..:.|...:|..::|||.    .|.| .:...:
Zfish   590 KP--------KNKD-----PLPKKSKKLSKKEGGKSNRSMAPPGAAPPTL----QPVPGLDTEED 637

  Fly  1968 LSKRGKSSEPSKSEASQKEKPNLSAWLKAFGGPKVSKKSEDEEKQ-QTPVQDLQGDSKVAPPAHS 2031
            |...|.::....: |.:|.||                .|.:|::| ...:..|.|| |:....| 
Zfish   638 LGLTGGAAMAGMA-AGEKCKP----------------MSYEEKRQLSLDINKLPGD-KLGRVVH- 683

  Fly  2032 PAGDNFSLPTVMRQRKPSTGSTNSERSSFSQDPDSPRIAID-ERYGSYAAGSYTSPIGASPIGAS 2095
                      :::.|:||..::|.:......:...|....: |||.|                  
Zfish   684 ----------IIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVS------------------ 720

  Fly  2096 PIMVSPKPNDDMGKPASPYPLNGAIKVGFYQDTTTKSSPDKSCSPREMNSPYPQYSQHIYSSASS 2160
                                                     ||..::.....|:.|....|:..:
Zfish   721 -----------------------------------------SCLRKKKKPAVPEKSMEAISAVKT 744

  Fly  2161 PNVSTPDMSGTSPYGGGNSYNPSG-SEASKTPAYSSTSPLPIYDQYKQPRSQ-ESDYNSSMSPST 2223
                    .|||...|.:|.:.|. ||.|:|...|...        |:.|.: :..::.:.:|..
Zfish   745 --------KGTSSDSGSSSESSSSESEDSETGMASKPK--------KRGRGEGKKAHHQTTAPGM 793

  Fly  2224 PNPHSPY--QQPQSSPYTTPQQSQSTHPSPYHNQSP------YHQQQHSPYHP-------PAAQQ 2273
            |.|..|.  |.|...|....:|.|..||||.....|      ..|...:|:.|       |....
Zfish   794 PLPQVPLQPQTPALQPSIQLKQQQPQHPSPAAYMPPPVTALEPSQLLENPFDPLAHFMHLPHHAN 858

  Fly  2274 QQQSSQPSH----------SPAAH----QQALSP---MHSV-----ESPASSAATQPPTPLAQSP 2316
            ...|..|.|          ||..|    |..:.|   :|:.     ..|::.||..||.||.||.
Zfish   859 DSSSPAPPHLNAHPPGGPVSPETHPFLNQHPILPSPALHNALPQQPSRPSNRAAPLPPKPLQQST 923

  Fly  2317 AEQQHSPYQQPVLSPYQ-QPQQQVQPPVVPPVQPSAGAQASTALGNNGYAPTHDSYQQLQQQQRS 2380
            ::||..| ||.::.|.| ||||| ||  .||.|.              :.|.|..:...|.:.|.
Zfish   924 SQQQPPP-QQTLVPPQQLQPQQQ-QP--APPQQQ--------------HLPHHPLHAPQQMRPRP 970

  Fly  2381 LYNPATLINPLSTAASSTASITKPNNDWSLNRSLLP-------PSITNTVNQAAQQQQQQQQQQA 2438
            | :|.|| .|....:|....:...:::..:....||       |........:..|..|.:.|..
Zfish   971 L-SPPTL-TPQGLLSSQPPQMLLEDDEEPVPSKSLPMYLQHLQPHRLQATPTSLMQSLQSRPQPP 1033

  Fly  2439 GQ--LQQQPQMQAAQQQLQSTPQQQQQQLQGTPQQQQLQGSQQQQQQQQQ----QQQLQTSQQQ- 2496
            ||  |.|..|:|:.....|...|.|.|..|..|.|...|.||.|.:..||    |..|||:|.| 
Zfish  1034 GQPSLLQSVQVQSHLPPPQLPVQTQVQPQQPAPHQPSPQLSQHQARHMQQLGFPQGPLQTAQTQP 1098

  Fly  2497 -----------QQQVLGHQQ--------QHK--------------------PKYPTYA-QYQS-T 2520
                       .||::..||        |||                    |:.|.|: .:|| :
Zfish  1099 GQHKVSMPSTKAQQIIQQQQATQHHSPRQHKADSYNSAHLRDNPSPLMMHSPQIPQYSLVHQSPS 1163

  Fly  2521 NAAANAAAAADAVDNLQQQQQKIAPPTYGSDMATFMQHQMQQPP----------------KTDTL 2569
            ...........|:..:::::...:|...|...:..|:.:..:.|                |...:
Zfish  1164 QDKKEPQRGPSALGGIKEEKLPPSPVMRGEPFSPAMRPESHKHPDSKPTMPGHSQQRADMKPLEM 1228

  Fly  2570 INPLKRPGEEIGMDYSGNAANKMQKREETPAQQQQQQQQQQPTQNQTQSLLNKQQQMFNSFLGTM 2634
            ..|:.|..|:.|...|.....|.::..:||:..::.|..:........||..|.....:|     
Zfish  1229 SRPVIRSSEQSGPPPSMQDKEKFKQEPKTPSAPKKVQDVKFKNMGSWASLAQKSSTTPSS----- 1288

  Fly  2635 AFGKPIGNIAPDKAFEMYNRAAAMGFPKDFAKDNSCQLQQQQQQQQSPQVTTNKQQANQQTQQQP 2699
                  |..:...:||.:.|||                :::::::::.:....:.:.::..::|.
Zfish  1289 ------GLKSSSDSFEQFRRAA----------------REKEEREKALKAQVEQAEKDRLRKEQE 1331

  Fly  2700 QQQSQQSQPHLTQLQTALSQNYQQQQQQTQAQKLPQQQQQQPPQQLNYQQQQAQLN--HNYTAQQ 2762
            :.:.:..:..:...:..|.:..::|:         .||.|.||||...|.|...||  .:.:|.|
Zfish  1332 KLRGRDEEDSIEPPRRPLEEPRRRQE---------PQQVQPPPQQHQTQAQAQTLNPAQSPSASQ 1387

  Fly  2763 QATAVPDKPPAAQSTV 2778
            ...|.|..|.::||.:
Zfish  1388 PTQAPPQSPASSQSAL 1403

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dikarNP_001261480.1 WHIM1 100..148 CDD:292246
Bromo_gcn5_like 892..991 CDD:99941 31/101 (31%)
brd4NP_001104751.1 bromodomain 1; BD1 40..152 39/170 (23%)
Bromo_Brdt_I_like 43..149 CDD:99929 37/164 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 154..217 18/187 (10%)
bromodomain 2; BD2 356..473 30/147 (20%)
Bromo_Brdt_II_like 363..464 CDD:99930 25/131 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 492..523 12/80 (15%)
NPS region. /evidence=ECO:0000250 498..517 7/57 (12%)
BID region. /evidence=ECO:0000250 538..610 21/93 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 540..645 30/130 (23%)
ET domain 654..729 22/161 (14%)
BET 657..721 CDD:293640 18/150 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1020..1422 86/420 (20%)
C-terminal (CTD) region. /evidence=ECO:0000250 1126..1444 54/314 (17%)
BRD4_CDT <1419..1444 CDD:293710
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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