DRSC/TRiP Functional Genomics Resources

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Protein Alignment dikar and ep300b

DIOPT Version :9

Sequence 1:NP_001261480.1 Gene:dikar / 38747 FlyBaseID:FBgn0261934 Length:3261 Species:Drosophila melanogaster
Sequence 2:XP_009297682.1 Gene:ep300b / 565612 ZFINID:ZDB-GENE-080403-15 Length:2646 Species:Danio rerio


Alignment Length:3187 Identity:580/3187 - (18%)
Similarity:924/3187 - (28%) Gaps:1112/3187 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   407 PPEEEQRQEPEELLAVSATD-DDFRSPEAPKSQTPAELKSKSSHHHHHHHHKKKKSSKKQKKRHH 470
            ||..::.:.....|:|||:| :||.|....:...|.||.:.|                       
Zfish    10 PPTAKRPKLSSPALSVSASDGNDFGSLFDLEHDLPDELINSS----------------------- 51

  Fly   471 RDKGRERDREHHHHH-------------------RRRHKHASE-ADEGEDDNNNHNSNSNSNSNT 515
             |.|.....:....|                   ..:|||.|| ...|...:.:..:.|..|:.:
Zfish    52 -DLGLPNGMDPSQLHTSLGGGGMSGPLGVSGQDTAAKHKHLSELLRPGAPPSASTATGSPGNAAS 115

  Fly   516 NSISSNNSVQPKRRRSGQQQQHHQQAETTEP------STSLSPEDKENFCRQLQL---------- 564
            ..:....|..|..:..|..||  |.:...:|      :.::....|.|...|..:          
Zfish   116 LGMMGGLSGGPVTQGMGGPQQ--QPSMMPQPGMVGGLNRAMMGTQKGNGQPQSMMGGQMMNGAPR 178

  Fly   565 -----LDTNSAAIAVATSIADLSLPSPVAHESETEQDEQVDQPAVVEAQPPALTSAMAPAANVKL 624
                 ::.|:........:.| ||..|.|       .:|:.|.|:...||.|:.......|    
Zfish   179 MGYANVNMNAGMAGNGNMLPD-SLQQPNA-------GQQMAQAAMRPQQPGAVNKMGMMGA---- 231

  Fly   625 PGRQTNNSLSSLTGNIFIPSGSAQQQQQQSQEPPSSSSSSQSGTTTTASTVRSKKQKAV------ 683
            ||..               .||..|...|||..|...:.:....:.....:..|.|...      
Zfish   232 PGPY---------------GGSYGQCGGQSQLGPQLQNKAGQPNSINQFNMDKKPQLGQNMGGMQ 281

  Fly   684 -------LNSSGSSSTSKMADKADRNL---------------SKTETTG----------KSKKSA 716
                   ::..|.::....||...|.|               .:.:..|          ::.|:.
Zfish   282 GPGVVGGVSGPGGTAAPPAADPEKRKLIQQQLVLLLHAHKCHRREQANGEVRQCNLPHCRTMKNV 346

  Fly   717 AGSSASSSSSKAERISGAYSDKSGDDHVNSSNR-------------STTNNNSSLNNNNNHKHAP 768
            ........:.|:.:::...|.:....|..:..|             ...|..|.|.........|
Zfish   347 LNHMTHCQAGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKSAGDKRNQQSLLGGAGMAMGGP 411

  Fly   769 --------HHSHNNNNNSHSTTTSATTTATTTTSQGYHYNSNLNHNQNHQNSHSHHTHHHHHHHH 825
                    ..|..|.|.......|:...|  ..:.|..|..|...|||.|.|..........::.
Zfish   412 LGGSLPGGQPSAPNINPPSQIDPSSIERA--YAALGLTYQGNQASNQNQQTSVPGQPGMRSLNNM 474

  Fly   826 HTTNN----------HSNKHKTKSHHSLAHNN------NNNNSPTTNPTSTSLLHPVTTNNNSTY 874
            ...|:          .||:|.......:.|.|      .|::|...|..|.:...|.:.....::
Zfish   475 AGGNSMGVNGGVGAPMSNQHPGMLPDGMLHRNMTAQSLMNDSSGVGNMGSAATATPPSAGMRKSW 539

  Fly   875 NSSNHANILSFTETEEVLQIGMHKVLVYVKNHRDAWPFVDPVE-EDIAPRYYSIIRRPMDLLKME 938
                |.:|     |:::....:||::..:      :|..||.. :|         ||..:|:...
Zfish   540 ----HEDI-----TQDLRNHLVHKLVQAI------FPTPDPAALKD---------RRMENLVAYA 580

  Fly   939 DKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMVNNLQDAFEKATKKYFDNLSDDEDDDP 1003
            .|::...|...:.....:.|:              .|.:..:|...|:..:..... .|....||
Zfish   581 RKVEGDMYESANSRAEYYHLL--------------AEKIYKIQKELEEKRRTRLQK-QDGPHSDP 630

  Fly  1004 NLSYPAADSKMNVFREKYFSKKAKEETEKDAPGRPAVSSAEEDLSEIEAEAP--QKAQKRKRKEK 1066
            :|......|:|             ....::..|.|...:......::..:.|  |:|        
Zfish   631 SLVQATGPSQM-------------VNRMQNPAGMPHSLNGMNQFGQVGMQQPMGQRA-------- 674

  Fly  1067 DKRRKKKTKSKADVETDDEDMEAEREPTPPPPPPTSKKSKTSKTGKEKEKDKEKEKDKDKEKDKE 1131
                                        .||.|..:..::.|..|..:.......:.:::....:
Zfish   675 ----------------------------TPPLPMGANLNQMSMQGTPRMAQPNVPQLQNQYMQNQ 711

  Fly  1132 TSSFKRG---------------------RKTKSDKSASKSSKKTKKGAKKSSADSDPESDPSDSR 1175
            .:....|                     ..|....|......:::.....|.|.:.|:..||   
Zfish   712 FTGTGAGLGQGAVGLNQPAGQGAMPQNQMPTPPSLSVHSPVAQSQSSVPVSGAAAGPQGPPS--- 773

  Fly  1176 ESEDYSDDDHISLAKTKSLVKPTARTIAAQKKKSVPAESKVKMPTPVKRQVKGKGKGGRKAKDDS 1240
                    :|...|.     :|...|.....:::.|:.::...|||...|...:..|.:..:..:
Zfish   774 --------NHPPPAP-----QPGLHTHCPPLRQNSPSPARSLTPTPAPHQTPPQLPGNQTPQPHT 825

  Fly  1241 LDSDQSDVNVKKQLPPTAAAALAESAAELEEDPDDPPPDEDEDEDSSRSRSMSPFKVDLHKKYSK 1305
            .:|..:......||||.|....:|.:::|::                             :.:..
Zfish   826 PNSSTTMAPPASQLPPMAQGVASEKSSQLQQ-----------------------------QSHGG 861

  Fly  1306 SALNDDLSELLTTVKKVPTAETTKLSARHQDEADEERSSRESDGDFK---SLSNSRGSSE--ERP 1365
            .|.....:.|.::   ||:.....| ..|......::||...||...   |:|::..||:  ...
Zfish   862 GATGGPQTGLASS---VPSQNAHGL-CTHPHSPLSQKSSATVDGQASTPASVSSADPSSQLTSSE 922

  Fly  1366 PVAKKGKKAESSKKEKEKKGRDKDRDRDKEKDKDKSRSAKDKKSKDESPVLVAAAEAAAVVQAEL 1430
            |.|....|.|..::::|::..::..|:                          |:...|.:|.|:
Zfish   923 PTAPLDSKTEVKQQDEEEENENETEDK--------------------------ASGKMAAMQTEI 961

  Fly  1431 DMLLPFMDKYDVIKYRRSRAAFSGSSASNSLAPSEDSKSAITKSNRENRKASAKREKSPDAVENK 1495
                                                                 |.|:.|   |.|
Zfish   962 -----------------------------------------------------KSEEKP---EIK 970

  Fly  1496 RGRKSKDQKRSKESDKAEKSDKASKADTEKHSEKSKKKEEPPKVVEKAQREKSPAPVSALETIKE 1560
            :...:.|:.:::..:.:...||..:..||...|:.......|...:..::|..|      :.:::
Zfish   971 KEEPAGDECKTEPMETSTAEDKKPEVKTEPKEEEVAGANSTPANTQSKKKEFKP------DELRQ 1029

  Fly  1561 PPAPTPIATSASGKVKEGPAKKEPKKRPDKQMPPPPKPADKSSEKGSGKKSSSKKAAQKAGQP-- 1623
            ...||          .|...:::|:..|.:|      |.|                .|..|.|  
Zfish  1030 ALMPT----------LEALYRQDPESLPFRQ------PVD----------------PQLLGIPVR 1062

  Fly  1624 -QTNNNTNLEALDV--------------------ETEQTLKDI-----NRWLEH----------- 1651
             :|:|.|||:..|:                    |..|.:.|:     |.||.:           
Zfish  1063 IRTSNKTNLDYFDIVKNPIDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKYCS 1127

  Fly  1652 -----------------------------------------TPRFTEFSSASNSPSRYNLLDD-- 1673
                                                     .||...:.|..||..:|.||.|  
Zfish  1128 KLAEVFEQEIDPVMQELGYCCGRKLEFSPQTLCCYGKQLCTIPRDAAYFSYQNSSPKYGLLADRY 1192

  Fly  1674 ------FDSGIGSKLDAADFRRPVALAAPKAELVPTKLAEALNELVSEPKEAVSKSESESVAPTP 1732
                  |:...|..:...|              .||:...::|      |:...:.:::::.|..
Zfish  1193 HFCEKCFNEIQGENVSLGD--------------DPTQPQTSIN------KDQFQRKKNDTLDPEL 1237

  Fly  1733 SSVSSSCGTPPHS---MHS----------------GNSIGSTSATAA------------------ 1760
            ......||...|.   :|:                .||....:..||                  
Zfish  1238 LLECGDCGRKMHQICVLHNETIWPSGFICDGCLKKSNSTRKENKYAAKRLPQTKLGNFLETRVND 1302

  Fly  1761 --SSSNCSNNSMPTPLPVAVTPTPTPAPPPLLPIPKPKEPSTTQLILNPP--------------- 1808
              ...|...:...|...|.::.......|.:    |.:...:.::..:.|               
Zfish  1303 YLKRQNHPESGEVTIRVVHISDKVVEVKPGM----KSRFVDSGEMSESFPYRTKALFAFEEIDGT 1363

  Fly  1809 ----------------PPPHIKQQLAKEAKRKSLKEKQAAQAAQAQQVKAKANVMRTIDRLQPGK 1857
                            |||:        .:|..:....:....|.:.::........|..|:..|
Zfish  1364 DVCFFGMHVQEYGSDCPPPN--------QRRVYISYLDSVHFFQPRHLRTGVYHEILIGYLEYVK 1420

  Fly  1858 AKGNLLQNVVAVKSTEEGGDSHAGVNPVTTKV----------KELKNALITETCEGAPKLSLGTV 1912
            ..|.::.::.|...: ||.|.....:|...|:          |::.:..:||......|    .:
Zfish  1421 KMGFVMGHIWACPPS-EGDDYIFHCHPSDQKIPKPKRLQEWYKKMLDKAVTERIVHDYK----DI 1480

  Fly  1913 LK--TQD-FSLGKS------------LEEMSGKKDANEDDRPNEEASPKNSSPPTTPNTEAPKPF 1962
            .|  |:| .:..|.            |||...:.:..|::|..||.:..:.|...|..       
Zfish  1481 FKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENNTSSESIDATNG------- 1538

  Fly  1963 EALHELSKRGKSSEPSKSEASQ--KEKPNLSAWLKAFGGPKVSKKSEDE-----EKQQT---PVQ 2017
            ::.:...|..|.:..:||..|:  |:||         |.|.||.....:     ||.:.   .::
Zfish  1539 DSKNAKKKNNKKTSKNKSSLSRANKKKP---------GMPNVSNDLSQKLYATMEKHKEVFFVIR 1594

  Fly  2018 DLQGD-SKVAPPAHSP------------------AGDNFSLPTVMRQRKPST------------- 2050
            .:.|. :...||...|                  |.|.....:.:|:.|.|:             
Zfish  1595 FIAGPAANSLPPISDPDTLMACDLMDGRDAFLTLARDKHLEFSSLRRAKWSSMCMLVELHNQTQD 1659

  Fly  2051 -------------------------------------------------GSTNSERSSFSQDP-D 2065
                                                             ..:|::.::.:|:| |
Zfish  1660 RFVYTCNECKHHVETRFHCTVCEDYDLCITCYNVKGHEHKMEKLGLGLDDESNNQAAASTQNPGD 1724

  Fly  2066 SPRIAID-------------------------ERYGSYAAGSYTSPIGASPIGASPIMVSPKPND 2105
            |.|::|.                         :|...:..|......|..||....|.:......
Zfish  1725 SRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAK 1789

  Fly  2106 DMGKPASPYPLNGAIKVGFYQDTTTKSSPDKSCSPREMNSPYPQYSQHIYSSASSPNVSTPDMSG 2170
            ...:...|.|....||....|..............|.|              |:...|..|...|
Zfish  1790 HCQETKCPVPFCLNIKHKLRQQQLQHRLQQAQMLRRRM--------------ATMQRVGQPPPCG 1840

  Fly  2171 TSPYGGGNSYNPSGSEASKTPAYSSTSPLPIYDQYKQPRSQESDYNSSMSPSTPNPHSPYQQPQS 2235
            ..|.||..|...:|:....||....|.|                    .:|.||...:|      
Zfish  1841 GGPPGGLPSPGNNGATGPSTPTSVGTQP--------------------ATPQTPTQLTP------ 1879

  Fly  2236 SPYTTPQQSQSTHPSPYHNQSPYHQQQHSPYHPPAAQQQQQSSQPSHSPAAHQQALSPMHSVESP 2300
            :..:.||......|:....|||.|...|.....|.|.....|.|....|   ||:|.   .|..|
Zfish  1880 NLISLPQPGAGGVPAGAPQQSPQHPVHHQFQQMPGAGGMMNSQQQQMVP---QQSLG---QVPHP 1938

  Fly  2301 ASSAATQP--PTPLAQSPAEQQHSPYQQPVL--SPYQQPQQQVQPPVVPP---------VQPSAG 2352
            .:.....|  |:|..||..:....|...|.|  :|...|..|.|.|..||         :|..|.
Zfish  1939 HNQYGPHPTGPSPNTQSQGKPGLGPATPPQLPSNPGTVPMAQQQQPTGPPAAAVEIAMKIQQVAD 2003

  Fly  2353 AQASTA--------LGNNGYAPTHDSYQQLQQQQRSLYNPATLINPLSTAASSTASITKPNNDWS 2409
            ||...|        ....|..|.|  :||.|.|....:....::.|...|:.:..|.    |...
Zfish  2004 AQRKMAQVQLLQRQAAQAGMMPQH--HQQPQGQIGVAHPGIGMVGPQGLASQAQTSA----NRVQ 2062

  Fly  2410 LNRSLLPPSITNTVNQAAQQQQQQQQQQAGQLQQQPQMQAAQQQLQS--TPQQQQQQLQGTPQQQ 2472
            :.:...|..:..    |...||||.||.|.|.|..|||...|.::..  .|||||...||.|.||
Zfish  2063 MEQQQGPQGMMG----AGPMQQQQPQQVAVQGQMPPQMHPQQPRMNPPLQPQQQQWPGQGMPTQQ 2123

  Fly  2473 Q-----LQGSQQQQQQQQQQQQLQTSQQQQQQVLGHQQQHKPKYPTYAQYQSTNAAANAAAAAD- 2531
            :     .||....|.|.|.||..|.:||||    ..|..::....:..|....:..|:.|||:: 
Zfish  2124 RPAMMSQQGMVSMQPQPQPQQPSQQTQQQQ----APQMPNRNALMSMVQAGLQSGVASGAAASNL 2184

  Fly  2532 ---AVDNL----------QQQQQKI----APPTYGSDMATFMQHQMQ------------------ 2561
               |:..|          |||||.:    :.|..   ||.|::.::.                  
Zfish  2185 PQGALQQLLRTLRSPSSPQQQQQVLNILRSSPLL---MAAFIKQRVHKYKGGTGGPSGPQGGPGP 2246

  Fly  2562 ---QPPKTDTLINPLKRPGEEIGMDYSGNAANKMQKREETPAQQQQQQQQQQPTQNQTQSLLNKQ 2623
               ||...:|   .:.:||..:|...  |..:::..::::   |||||.||:|...|.|....:|
Zfish  2247 MGGQPVGVNT---GVPQPGMHLGQGV--NMQSQLLSQQQS---QQQQQMQQRPLLQQQQVAALQQ 2303

  Fly  2624 QQMFNSFLGTMAFGKPIGNIAPDKAFEMYNRAAAMGFPKDFAKDNSCQLQQQQQQQQSPQVTTNK 2688
            ||                                             |.||||||||..|....:
Zfish  2304 QQ---------------------------------------------QQQQQQQQQQQQQQHQQQ 2323

  Fly  2689 QQANQQTQQQPQQQSQQSQ-------PHLTQLQTALSQNYQQQQQQTQAQKLPQQQQQQPPQQLN 2746
            ||..|..|||.|||..|.|       ||..:|.....|..|.||||.|.|   ||||||......
Zfish  2324 QQQQQHQQQQQQQQGIQGQGTPNMANPHFRELVMRRQQQLQFQQQQQQQQ---QQQQQQMSNHAA 2385

  Fly  2747 YQQQQAQLNHNYTAQQ------------------QATAVPDKPPAAQSTVAAAVSESSSNMMNLP 2793
            :||||     .|.:||                  |....|..|  ||...|||:.:      .|.
Zfish  2386 FQQQQ-----GYMSQQGNMQVPPGGQPLQGVQPGQQQNFPGNP--AQQQAAAALQQ------RLA 2437

  Fly  2794 STAHQHHLSQTHHLAAYNKPTPP---PPQTYSNPLMQS---MLGYAGNYFDKTMPPAAHMYSASS 2852
            ...||..:.|..:.|.......|   |..|...|.:||   :|..|  ...:..|...|:...| 
Zfish  2438 QQQHQLQMQQQQNAATQGPDMGPGGGPQPTQLGPGLQSPQALLQQA--LHQRLFPQQQHLSGTS- 2499

  Fly  2853 SAASAYGNPAQQLPGNYVPGNNNPAHQQQQQ-PQQQQQQQQQAPAVPPAEVKAPAKRGRKKKAAT 2916
                    ||||         |||...|||| .|....|.||.|:....:|.:|           
Zfish  2500 --------PAQQ---------NNPMSPQQQQISQSPHLQGQQLPSSLSNQVCSP----------- 2536

  Fly  2917 IAAEAAAAAAKQQQQQQQQQQQQAQQQQQVAAQQQHQQQQVSAQQQ---------QQQHQQVAAQ 2972
                         |...:.|.|..........|.|.....:|.|.|         ||.|..:|..
Zfish  2537 -------------QPSPRPQSQPPHSSPSPRLQPQPSPHHISPQTQTGSPHPSHLQQHHSGMAPP 2588

  Fly  2973 QQQHQAMPQYNM--PQSMASAAAATNNQLQAHAQALQQGFQLYAGLKSGGVSS---PVGSSAATP 3032
            ...|| .||:|.  |....:...|..:||..           .|||...|.:.   |.|......
Zfish  2589 PPPHQ-QPQHNSKDPSGFGADQNAMLSQLSG-----------MAGLHGPGANDMLPPSGQDLGIN 2641

  Fly  3033 VN 3034
            :|
Zfish  2642 MN 2643

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dikarNP_001261480.1 WHIM1 100..148 CDD:292246
Bromo_gcn5_like 892..991 CDD:99941 15/99 (15%)
ep300bXP_009297682.1 zf-TAZ 318..385 CDD:280324 6/66 (9%)
KIX 534..614 CDD:280354 17/117 (15%)
Bromo_cbp_like 1024..1142 CDD:99927 24/155 (15%)
RING_CBP-p300 1154..1236 CDD:276805 16/101 (16%)
PHD_SF 1237..1271 CDD:304600 4/33 (12%)
HAT_KAT11 1300..1607 CDD:285432 54/339 (16%)
ZZ_CBP 1663..1703 CDD:239077 0/39 (0%)
ZnF_TAZ 1724..1802 CDD:214717 12/77 (16%)
Creb_binding <2164..2231 CDD:286163 16/69 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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