DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dikar and Cecr2

DIOPT Version :9

Sequence 1:	NP_001261480.1	Gene:	dikar / 38747	FlyBaseID:	FBgn0261934	Length:	3261	Species:	Drosophila melanogaster
Sequence 2:	XP_008761473.1	Gene:	Cecr2 / 500308	RGDID:	1564182	Length:	1465	Species:	Rattus norvegicus

Alignment Length:	2514	Identity:	449/2514 - (17%)
Similarity:	675/2514 - (26%)	Gaps:	1245/2514 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GLLDIQSWWEIPCISHFCSLFSSAFDLPDIDIEDLESALLSDGTSDEDQVALVPELIVRLLKGCD 71
            ||.:::||||:|.|:||||||.:||.|||.:||:||:||      ..|.|..:.:||..||:||
  Rat    10 GLGELRSWWEVPAIAHFCSLFRTAFRLPDFEIEELEAAL------HRDDVDFISDLIACLLQGC- 67

  Fly    72 ALQTVAKEITHSNYQMFLRRFLRQQCRLHQTENHFDTDIDFQSLPVRKRLHILHDLCHFRLDSVD 136
               ...::||...:..:|...:..:..|.:.:.:...:..||.||:|.|:.|||.||.:|||:.|
  Rat    68 ---YQRRDITPQTFHSYLEDIINYRWELEEGKPNPLREASFQDLPLRTRVEILHRLCDYRLDADD 129

  Fly   137 VQVILSNLEADSLRVEPLGYDAKNSGYWYFYGTRLYREDKATGGSASSSSGSGS----------- 190
            |..:|..|:||||||||||.|...:.||||||||:|:||...|.|....|.|..
  Rat   130 VFDLLKGLDADSLRVEPLGEDNSGALYWYFYGTRMYKEDPVQGRSNGELSLSRESERQKNVSNVP 194

  Fly   191 GGAGASTGGASNSKGI-----------------------GSNGT---VWQVICFTEEDWQNLAAK 229
            |..|...|.....|.:                       ||.|.   .|.::|.|||:|:.:...
  Rat   195 GKTGKRRGRPPKRKKLQEEIISSEKQEENSLTSDLQTRNGSRGPGQGTWWLLCQTEEEWRQVTES 259

  Fly   230 FKTSTNAKERELFNILDDNFLPKLPQLFRERERLRRRKLLQVRNSSRIRNIAELKARQEEERQRR 294
            |:..|:.:||:|:.:|.::|||::..:.
  Rat   260 FRERTSLRERQLYKLLSEDFLPEICNMI------------------------------------- 287

  Fly   295 ERENLYQDRQNAHWLAPPQQQQQQQQQQQQQQQQSQQRTRRRSQSTSTASGISTYASSLRRTTTT 359
                                         .|:.:..|||:...|....:..:|..::.|..|...
  Rat   288 -----------------------------AQKGKRPQRTKPELQHRFMSDHLSIKSTKLEETPML 323

  Fly   360 NSSEFLCHRETFCLSPENDEDDDDDDEALDAEQQSDQPEQQRQQEEQPPEEEQRQEPEELLAVSA 424
            ...|           .:..::::::.:.|.|.|:.:|        ||..:||:::|.||  .|.|
  Rat   324 TKIE-----------KQKRKEEEEERQLLLAVQKKEQ--------EQMLKEERKRELEE--KVKA 367

  Fly   425 TDDDFRSPEAPKSQTPAELKSKSSHHHHHHHHKKKKSSKKQKKRHHR----DKGRERDREHHHHH 485
            .:|                                 .:|::|.|..|    .:|:|
  Rat   368 VED---------------------------------RAKRRKLREERAWLLAQGKE--------- 390

  Fly   486 RRRHKHASEADEGEDDNNNHNSNSNSNSNTNSISSNNSVQPKRRRSGQQQQHHQQAETTEPSTSL 550
                                                                            |
  Rat   391 ----------------------------------------------------------------L 391

  Fly   551 SPEDKENFCRQLQLLDTNSAAIAVATSIADLSLPSPVAHESETEQDEQVDQPAVVEAQPPALTSA 615
            .||                        ::.|.|.||:....:|:...::|
  Rat   392 PPE------------------------LSHLDLNSPMREGKKTKDIFELD--------------- 417

  Fly   616 MAPAANVKLPGRQTNNSLSSLTGNIFIPSGSAQQQQQQSQEPPSSSSSSQSGTTTTASTVRSKKQ 680

  Rat   418 ----------------------------------------------------------------- 417

  Fly   681 KAVLNSSGSSSTSKMADKADRNLSKTETTGKSKKSAAGSSASSSSSKAERISGAYSDKSGDDHVN 745
                                                                        ||
  Rat   418 ------------------------------------------------------------DD--- 419

  Fly   746 SSNRSTTNNNSSLNNNNNHKHAPHHSHNNNNNSHSTTTSATTTATTTTSQGYHYNSNLNHNQNHQ 810

  Rat   420 ----------------------------------------------------------------- 419

  Fly   811 NSHSHHTHHHHHHHHHTTNNHSNKHKTKSHHSLAHNNNNNNSPTTNPTSTSLLHPVTTNNNSTYN 875

  Rat   420 ----------------------------------------------------------------- 419

  Fly   876 SSNHANILSFTETEEVLQIGMHKVLVYVKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDK 940
                     ||        .|:|||..||.|:|:|||::||:|..||.||.||:.|||:..||.|
  Rat   420 ---------FT--------AMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKIPMDISSMEKK 467

  Fly   941 LDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMVNNLQDAFEKATKKYFDNLSDDEDDDPNL 1005
            |:.|.|....||.||.:.:..|||.|||.::|||:|..||:..|.:|..|:|.  .:|.|.|
  Rat   468 LNGGLYCTKEEFVNDMKTMFRNCRKYNGDSSEYTKMSENLERCFHRAMTKHFP--GEDGDTD--- 527

  Fly  1006 SYPAADSKMNVFREKYFSKKAKEETEKDAPGRPAVSSAEEDLSEIEAEAPQKAQKRKRKEKDKRR 1070
                         |:::.:    |.||                                 ::|||
  Rat   528 -------------EEFWIR----EDEK---------------------------------REKRR 542

  Fly  1071 KKKTKSK-ADVETDDEDMEAEREPTPPPPPPTSKKSKTSKTGKEKEKDKEKEKDKDKEKDKETSS 1134
            .:..:|. :.|.|...|.|......||.                            :...|....
  Rat   543 SRAGRSSGSHVWTRSRDTEGSSRKQPPM----------------------------ENGGKSLPP 579

  Fly  1135 FKRGRKTKSDKSASKSSKKTKKGAKKSSADSDPESDPSDSRESEDYSDDDHISLAKTKSLVKPTA 1199
            .:|...:..|:|:             ||....||...|:.|   .:....|.|
  Rat   580 ARRAASSGDDQSS-------------SSIQLPPEVGTSNGR---GFFHPLHYS------------ 616

  Fly  1200 RTIAAQKKKSVPAESKVKMPTPVKRQVKGKGKGGRKAKDDSLD-SDQSDVNVKKQLPPTAAAALA 1263
                     .||:::      |...|::....|    ...||. ||.::::...::|
  Rat   617 ---------RVPSQA------PPLNQMRPAASG----TFGSLQGSDPTNLHGSSRIP-------- 654

  Fly  1264 ESAAELEEDPDDP---PPDEDEDEDSSRSRSMSPFKVDLHKKYSKSALNDDLSELLTTVKK---- 1321
                  |..|.:|   ||          ....:|..:..|:....||..:.:...||.:..
  Rat   655 ------EVPPGEPLQHPP----------FAIQAPVGISNHRGSRLSAPEEKMCGGLTHLSNMGSH 703

  Fly  1322 VPTAETTKLSARHQDEADEERSSRESDGDFKS--LSNSRGSSEERPPVAKKGKKAESSKKEKEKK 1384
            ||:.:..:::...||      .:......|::  :.:..|.:..|||     ...|||:
  Rat   704 VPSLQLGQMNCNSQD------GNIYPPAPFQAGFIPSRHGGTPARPP-----DFPESSE------ 751

  Fly  1385 GRDKDRDRDKEKDKDKSRSAKDKKSKDESPVLVAAAEAAAVVQAELDMLLPFMDKYDVIKY--RR 1447
                                                             :|....|...||  |.
  Rat   752 -------------------------------------------------IPPSHIYHSYKYLNRV 767

  Fly  1448 SRAAFSGSSASNSLAPSEDSKSAITKSNRENRKASAKREKSPDAVENKRGRKSKDQKRSKESDKA 1512
            ..|.::|:..:.:                                   .||...|:|
  Rat   768 HPAVWNGNHGTTN-----------------------------------PGRLGPDEK-------- 789

  Fly  1513 EKSDKASKADTEKHSEKSKKKEEPPKVVEKAQREKSPAPVSAL---ETIKEPPAPT--------- 1565
                                    |.|...|...  |..:..:   ..:::|..|.
  Rat   790 ------------------------PLVGPGASHH--PHALGHMMDGRVMRQPIPPNQWTKQSSFL 828

  Fly  1566 PIATSASGKVKEGPAKKEPKKRPDKQMPPPPKPADKSSEKGSGKKSSSKKAAQKAGQPQTNNNTN 1630
            |....:||.:      :.|.|....::.|||.||.
  Rat   829 PPGVPSSGYM------QPPCKSAGHRLQPPPTPAP------------------------------ 857

  Fly  1631 LEALDVETEQTLKDINRWLEHTPRFTEFSSASNSPSRYNLLDDFDSGIGSKLDAADFRRPVALAA 1695
                                 :|||       ..||:                        ||..
  Rat   858 ---------------------SPRF-------RGPSQ------------------------ALRG 870

  Fly  1696 PKAELVPTKLAEALNELVSEPKEAVSKSESESVAPTPSSVSSSCGTPPHSMHSGNSIGSTSATAA 1760
                      |:....::..|:....:..|..|.|.        |.|.|
  Rat   871 ----------AQGGESMMDSPEMIAMQQLSSRVCPP--------GVPYH---------------- 901

  Fly  1761 SSSNCSNNSMPTPLPVAVTPTPTPAPPPLLPIPKPKEPSTTQLILNPPPPPHIKQQLAKEAKRKS 1825
                                 |....||.||.|.|:...:..:.::.|.|     .|......:.
  Rat   902 ---------------------PRQPTPPQLPGPFPQVAHSASVCVSAPKP-----ALDNPGSTQE 940

  Fly  1826 LKEKQAAQAAQAQQVKAKANVMRTIDRLQPGKAKGNLLQNVVAVKSTEEGGDSHAGVNPVTTKVK 1890
            :.|.|..:..:|:.|              ||      |:...|...:.||           ..:|
  Rat   941 ISETQEPEGDRAEPV--------------PG------LEEKAASICSSEG-----------LYLK 974

  Fly  1891 ELKNALITETCEGAPKLSLGTVLKTQDFSLGKSLEEMSGKKDANEDDRPNEEASPKNSSP-PTTP 1954
            :|.:.        ||.||.....::....  :..|:...|.||: |.....:|| ||.:| |...
  Rat   975 QLPHP--------APPLSASCTRQSSPHE--RETEDSQLKSDAS-DSADTYKAS-KNKNPWPLDN 1027

  Fly  1955 NTEAPKPFEALHE------LSKRGKSSE--------PSKSEASQKEKPNLSAWLKAFGGPKVSKK 2005
            :..:.....|||.      :::||...|        |.:||.            |..||....|.
  Rat  1028 SYNSAAVQGALHGGRDLAIVTERGNLPENGVVGEASPCRSEG------------KGLGGSGSEKP 1080

  Fly  2006 SEDEEKQQTPVQDLQGDSKVAPPAHSP---AG--DNFSLPTVMRQRKPSTGSTN----------- 2054
            .....|.........|.:...||...|   ||  :.|| |..|...:.|..:|:
  Rat  1081 LCPRGKTLQETVPCTGQNATTPPCTDPNLMAGTVNQFS-PLYMPGIEYSNSATHYPMSPSLQGLG 1144

  Fly  2055 ---------SERSSFSQ---DPDSPRIAIDERYG-------SYAAGS------------YTSPIG 2088
                     |:..|||.   ..:.|...:..||.       ||...|            ||.|.|
  Rat  1145 SMMGAKSPGSQPQSFSPRSFQANGPHPGLFPRYRPQQGMRYSYQPSSQPSYHPYQRTPYYTCPQG 1209

  Fly  2089 ASPIGAS-PIMVSPKPNDDMGKPAS--PYP----------------LNGAIKVGFYQDTTT---- 2130
            .|....| |...||.     |.|.|  |.|                ||.|:......|...
  Rat  1210 FSDWQRSLPSQRSPS-----GPPGSHPPRPLFSDKNALTSLQGCETLNAALTSPTQMDAVAAKVV 1269

  Fly  2131 -----KSSPDKSCSPREMNSPYPQYSQHIYSSASSPNVSTPDMSGTSPYGGGNSYNPSGSEASKT 2190
                 .|.|::......|..|   .|...:....:.|.:|...|..|.    |.|
  Rat  1270 PPDGHNSGPEEEKMDESMERP---ESPKEFLDLDNHNAATKRQSSLST----NDY---------- 1317

  Fly  2191 PAYSSTSPLPIYDQYKQPRSQESDYNSSMSPSTPNPHSPYQQPQSSPYTTPQQSQS--------- 2246
             .|.:..|         |.|....:.||..|    |||...| ..||| |||:|.|
  Rat  1318 -LYGAPPP---------PLSSGMTFGSSAFP----PHSVMLQ-TGSPY-TPQRSASHFQPRAYAS 1366

  Fly  2247 ---THPSPY------HNQSP----YHQQQHSPYHPPAAQQQQQ--------SSQPSHSPAAHQQA 2290
               .||.|:      :..||    |..|:....|..||..:|.        |.|.:|.|...|
  Rat  1367 PVPAHPPPHPVATQPNGLSPEGPLYCCQEEGLGHFQAAMMEQTGTGSGIRGSFQDAHRPPGLQ-- 1429

  Fly  2291 LSPMHSVESPASSAATQPPTPLAQSPAEQQHSPYQQPVLSPYQQ 2334
               ||    |..|.:..|.|| |.:.:.:|..|::.|.| |..|
  Rat  1430 ---MH----PIQSQSLFPKTP-APAASPEQLPPHKAPTL-PLDQ 1464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246	19/47 (40%)
dikar	NP_001261480.1	Bromo_gcn5_like	892..991	CDD:99941	47/98 (48%)
Cecr2	XP_008761473.1	WHIM3	244..284	CDD:292248	14/39 (36%)
Cecr2	XP_008761473.1	Bromo_gcn5_like	418..518	CDD:99941	51/249 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7330
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007388
OrthoInspector	1	1.000	-	-		oto98297
orthoMCL	1	0.900	-	-		OOG6_106343
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.800