DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dikar and tbrd-1

DIOPT Version :9

Sequence 1:NP_001261480.1 Gene:dikar / 38747 FlyBaseID:FBgn0261934 Length:3261 Species:Drosophila melanogaster
Sequence 2:NP_001369030.1 Gene:tbrd-1 / 42823 FlyBaseID:FBgn0039124 Length:513 Species:Drosophila melanogaster


Alignment Length:608 Identity:115/608 - (18%)
Similarity:189/608 - (31%) Gaps:192/608 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   841 HSLAHNNNN---NNSPTTNPTSTSLLHPVTTNNNSTYNSSNHANILSFTETEEVLQIGMHKVLVY 902
            :.|..|:|.   .|.|...|.:..:..||....|   ......|||     ||     :..||..
  Fly     2 NELQSNSNQPPPRNEPYLQPVNGIVQPPVIPPPN---RPGRRTNIL-----EE-----LKSVLNC 53

  Fly   903 VKNHRDAWPFVDPVEEDI--APRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRL 965
            :..:|.::.|..||:...  .|.|:::::.||||..:..:|.:..|.:.||...||:||.:||.|
  Fly    54 LWRNRFSYHFRHPVDSVSLGVPDYHAVVKHPMDLSTIRKRLHNKYYWQASEALEDFKLIFDNCLL 118

  Fly   966 YNGHNNEYTEMVNNLQDAFEKATKKYFDNLSDDEDDDPNLSYPAADSKMNVFREKYFSKKAKEET 1030
            ||...:...:....|.:||                      |...:|                  
  Fly   119 YNLEGSPVYQAGKLLMEAF----------------------YMRMES------------------ 143

  Fly  1031 EKDAPGRPAVSSAEEDLSEIEAEAPQKAQKRKRKEKDKRRKKKTKSKADVETDD---EDMEAERE 1092
                          .||| .|.|...|::|||||..:...:..|...|...:::   :.:.:...
  Fly   144 --------------IDLS-TEVELKPKSEKRKRKATESLDQASTSFSAPRASNNYSRQWLSSSSS 193

  Fly  1093 PTPPPPPPTSKKSKTSKTGKEKEKDKEKEKDKDKEKDKETSSFKRGRKTKSDKS----------- 1146
            ...|||.|..                             .|||....:.....|           
  Fly   194 WLCPPPMPGG-----------------------------VSSFNPSFRNFVGPSLIPSFMPDSLV 229

  Fly  1147 ---------ASKSSKKTKKGAKKSSADSDPESDPSDSRESEDYSDDDHISLAKTKSLVKPTARTI 1202
                     :|..:...|...:.:.|...|.|:|...|..:        |||  ..|..|....:
  Fly   230 NPMQSMHPMSSMMNPIFKNNWETNEAMDPPPSEPISYRPLD--------SLA--APLPSPPMEPM 284

  Fly  1203 AAQKKKSVPAESKVKMPTPVKRQ---VKGKGKGGRKAKDDSLDSDQSDVNVK-----KQLPPTAA 1259
            ........|.||....|.|....   :      ..|:.|..::...||..:|     |:...|.|
  Fly   285 TLPWPTPAPVESPASSPPPAPNPPIII------CYKSLDRMIEKSHSDHLLKSMVKRKRKQVTWA 343

  Fly  1260 AALAESAAELEEDPDDPPPDEDEDE-----------DSSRSRSMSPFKVDLHKKYSKSALNDDLS 1313
            ...|:......::||   .|.|.:|           ||....|...|...:.|.:..:       
  Fly   344 FNQADYWRRYSQNPD---YDHDREEKLDWKILQERLDSDNFESFDGFVSSVRKMFQNA------- 398

  Fly  1314 ELLTTVKKVPTAETTKLSARHQDEADEERSSRESDGDFKSLSNSRGSSEERPPVAKKGKKAESSK 1378
                 ::..|.....|:|.:..:|..|:|..:     ::.|            :|...:|.....
  Fly   399 -----LRCFPEDGLVKVSVKKTNEIFEKRLPK-----YREL------------IATAKEKGRQLV 441

  Fly  1379 KEKEKKGRDKDRDRDKEKDKDKS 1401
            ..:|:..||......|:::.:|:
  Fly   442 ASREQDFRDSQNLLIKQENANKN 464

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dikarNP_001261480.1 WHIM1 100..148 CDD:292246
Bromo_gcn5_like 892..991 CDD:99941 28/100 (28%)
tbrd-1NP_001369030.1 Bromodomain 39..143 CDD:413371 34/135 (25%)
Bromodomain 328..423 CDD:413371 20/109 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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