DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dikar and Gcn5

DIOPT Version :9

Sequence 1:	NP_001261480.1	Gene:	dikar / 38747	FlyBaseID:	FBgn0261934	Length:	3261	Species:	Drosophila melanogaster
Sequence 2:	NP_648586.2	Gene:	Gcn5 / 39431	FlyBaseID:	FBgn0020388	Length:	813	Species:	Drosophila melanogaster

Alignment Length:	982	Identity:	170/982 - (17%)
Similarity:	299/982 - (30%)	Gaps:	331/982 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 SLRVEPLGYDAKNSGYWYFYGTRLYREDKATGGSASSSSGSGSGGAGASTGGASNSKGIGS---N 209
            :::.:|:  |..|:|     .....::.:|..|:|::.: ||:.|:..:.|....:.|.||   .
  Fly     8 TIKSQPI--DGNNTG-----NAAAQQQQQAANGAATAGA-SGAAGSAQNPGHGGAASGAGSVPAE 64

  Fly   210 GTVWQVICFTEEDWQNLAAKFKTSTNAKERELFNILDDNFLPKLPQLFRERERLRRRKLLQVRNS 274
            ||                                  ..|.|.::.|        |::|:..:...
  Fly    65 GT----------------------------------RQNSLQRIQQ--------RKQKVFNLPVP 87

  Fly   275 SRIRNIAELKARQEEERQ----RRERENLYQDRQNAHWLAPPQQQQQQQQQQQQQQQQSQQRTRR 335
            .::..::...|.|.|..:    :..:||.::|.::::.   |:..::
  Fly    88 QKLAKLSMYSACQSEGCRCTGWKTPQENRHRDVESSYC---PEFNEE------------------ 131

  Fly   336 RSQSTSTASGISTYASSLRRTTTTNSSEFL---CHRETFCLSPENDEDDDDDDEALDAEQQSDQP 397
             .::||....:.::.:.|...::::.:|.|   ...|...:|.:..||:|.........:...|.
  Fly   132 -CRNTSCRHSLRSHIAHLDNISSSSMNELLGAIIDMENLFMSMQRVEDEDTKKVYQYLFRLLRQC 195

  Fly   398 EQQRQQEEQPPEEEQRQEPEELLAVSATDDDFRSPEA-PKSQTPAELKSKSSHHHHHHHHKKKKS 461
            ...|||                 ||      .|.|.. |..:||...|:..|...:.:
  Fly   196 VLTRQQ-----------------AV------IRGPLGDPPFETPCITKAVLSLVFYKY------- 230

  Fly   462 SKKQKKRHHRDKGRERDREHHHHHRRRHKHASEADEGEDDNNNHNSNSNSNSNT-------NSIS 519
                                                      ||.|.....:.|       |.::
  Fly   231 ------------------------------------------NHLSTPELQTMTEVAKTFLNFLN 253

  Fly   520 SNNSVQPKRRRSGQQQQHHQQAETTEPSTSLSPEDKEN----------------FCRQLQLLDTN 568
            ..|...|..||.                 .|:.||..|                ||..|:..:|:
  Fly   254 HYNFESPSTRRG-----------------DLTHEDASNYKINYTRWLVFCHVPAFCNSLRQCETS 301

  Fly   569 SAAIAVATSIADLSLPSPVAHESETEQDE-QVDQPAVVEAQPPALTSAMAPAANVKLPGRQTNNS 632
            ..............:...:..:..:|:|. ..|:.:::...|..|.:..|.......|...|:
  Fly   302 LVFGRTLLRTVFQCMSQQLKKKCISERDRFPEDKRSIITLMPKFLETLRAELLKDDSPIWDTS-- 364

  Fly   633 LSSLTGNIFIPSGS-AQQQQQQSQE------PPSSSSSSQSGTTTTASTVRSKKQKAVLNSSGSS 690
                    :.||.| ..||::::||      .||::|...:..|:....:..:.:|...:...|.
  Fly   365 --------YRPSNSFVIQQRKRNQEVANVPIGPSAASIGGNKRTSVGEPLHKRIKKEPTDRPSSE 421

  Fly   691 STSKM-AD---KADRNLSKTETTGKSKKSAAGSSASSSSSKAERISGAYSDKSGDDHV--NSSNR 749
            :...: ||   :|.:::|:::||.|::.....:.:...:.|||.     ..::.:.||  ||..:
  Fly   422 NLDDLPADVVMRAMKSVSESKTTNKAEILFPVNVSRDENVKAEE-----QKRAIEFHVVGNSLTK 481

  Fly   750 STTNNN-----------------------SSLNNNNNHK---------------HAPHHSHNNNN 776
            ......                       |.|..:..||               ..|..|..
  Fly   482 PVDKQTVLWLLGLQLVFAYQLPEMPREYISQLVFDTKHKTLALIKENQPIGGICFRPFPSQG--- 543

  Fly   777 NSHSTTTSATTTATTTTSQGYHYNSNL-NHNQNHQ------------------------------ 810
                 .|.....|.|.:.|...|.::| ||.:::.
  Fly   544 -----FTEIVFCAVTMSEQVKGYGTHLMNHLKDYSIQRGIKHLLTFADCDAIGYFKKQGFSKDIK 603

  Fly   811 ----------NSHSHHTHHHHHHHHHTTNN------HSNKHKTKSHHSLAHNNNNNNSPTTNPTS 859
                      ..:...|..|...|....|.      .|.....|...:..||......|......
  Fly   604 LARPVYAGYIKEYDSATLMHCELHPSIVNTQFIAVIRSQSEILKELIAQRHNEVQKVRPGLTCFK 668

  Fly   860 TSL-LHPVTT----------NNNSTYNSSNHANILSFTETEEVLQIGMHKVLVYVKNHRDAWPFV 913
            ..| :.||.:          ..|....||..   |..:...|.|......||..|:.|..||||:
  Fly   669 EGLPVIPVESIPGLREIGWKPQNRPARSSRP---LEESTDPEKLATSFASVLQSVRQHTTAWPFL 730

  Fly   914 DPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMVN 978
            .||.....|.||..|:.||||..|.::|..|.|.....|..|...|.:|||.||..:.||....|
  Fly   731 RPVTAAEVPDYYDHIKYPMDLKTMGERLKKGYYQTRRLFMADMARIFSNCRFYNSPDTEYYRCAN 795

  Fly   979 NLQDAFE 985
            :|:..|:
  Fly   796 SLERYFQ 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246	170/982 (17%)
dikar	NP_001261480.1	Bromo_gcn5_like	892..991	CDD:99941	36/94 (38%)
Gcn5	NP_648586.2	PCAF_N	73..322	CDD:283997	50/367 (14%)
		COG5076	451..807	CDD:227408	74/368 (20%)
		Acetyltransf_1	526..598	CDD:278980	10/79 (13%)
		Bromo_gcn5_like	708..808	CDD:99941	36/95 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900