DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dikar and brd9

DIOPT Version :9

Sequence 1:	NP_001261480.1	Gene:	dikar / 38747	FlyBaseID:	FBgn0261934	Length:	3261	Species:	Drosophila melanogaster
Sequence 2:	XP_005170179.1	Gene:	brd9 / 393245	ZFINID:	ZDB-GENE-060502-1	Length:	651	Species:	Danio rerio

Alignment Length:	676	Identity:	149/676 - (22%)
Similarity:	221/676 - (32%)	Gaps:	188/676 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   801 SNLNHNQNHQNSHSHHTHHHHHHHHHTTNNHSNKHK---------TKSHHSLAHNNNNNNSPTTN 856
            |...|:.::.:..|.|....|..........|.|.|         .|...........:.:.:|.
Zfish    43 SGSGHDSSYYDDRSDHEWERHKEKKKKKKKKSEKEKYADDDERRRRKEEKKKKREREQSETASTA 107

  Fly   857 PTST-SLLHPVTT------NNNSTYNSSNHANILSFTETEEVLQIGMHKV-LVYVKNHRDAWP-- 911
            |... :|..||..      .....:.|.:.|:........||.|.....| ....:...:|.|
Zfish   108 PVEPFTLPKPVEVVVEEKKRKRDKFESESEADEFHPAVKVEVEQPADRPVRACRTQQENEATPRQ 172

  Fly   912 ------------------FVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRL 958
                              |..||.:.|||.|..||:.|||...|:||:.:.||...:||:.||:|
Zfish   173 QLLEHFLRLLQRKDAHGFFAFPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKL 237

  Fly   959 IVNNCRLYNGHNNEYTEMVNNLQDAFEK--------ATKKYFDNLSDDE---------DDDPNLS 1006
            :.:|..:||.....|.:....|.....|        |.|:....:.|.:         |||....
Zfish   238 MCDNAMVYNRPETVYYKAAKKLLHTGFKMMSKERLLALKRSMSFMQDMDFSQQAAILGDDDIAPE 302

  Fly  1007 YPAADSKMNVFREKYFSKKAKEETEKDAPGRPAV---------------SSAEEDLSEIEAEAPQ 1056
            .|..: .|.:..|  :.||:|::..|:    |.:               |:|||.:..:...|..
Zfish   303 EPVTE-MMPIHTE--YPKKSKKQPVKE----PIISDMYELEGNACSLTDSTAEEHVLALVEHAAD 360

  Fly  1057 KAQKRKRK----EKDKRRKKKTKSKADVETDDEDMEAEREPTPPPPPPTSKKSKTSKTGKEKEKD 1117
            :|:.|..:    .|....||.|:........::|.|.|.|.|.|
Zfish   361 EARDRINRFMPNSKIGYLKKDTEGSLMYVVVNQDPEGEEEETHP--------------------- 404

  Fly  1118 KEKEKDKDKEKDK-----ETSSFKRGRKTKSDKSASKSSKKTKKGAKKSSADSDPESDPSDSRES 1177
                .|.....:|     .:..||..|:.|....:|..:.:|   .:.:|...|...:..|...|
Zfish   405 ----VDLSSLANKLIPGLTSLGFKDDRRHKVTFLSSAYNTQT---LQNNSIYPDLHPEEMDMLYS 462

  Fly  1178 EDYSDDDHISLAKTKSLVKPTARTIAAQKKKSVPAESKVKMPTPVKRQVKGKGKGGRKAKDDSLD 1242
            . |.|                              |:.|:....::..|||.|...::..||.||
Zfish   463 A-YGD------------------------------ETGVQCALSLQEFVKGCGGFTKRLVDDLLD 496

  Fly  1243 ----SDQS----DVNVKKQLPPTAAAALAESAAELEEDPDDPPPDEDEDEDSSRSRSMSPFKVDL 1299
                .|.|    .:..|:.||      :.|:.:.|   .|.|..|....|..|....||
Zfish   497 KMTAGDHSKAVVQIRQKRNLP------IDEAKSSL---CDMPGTDGGGMEAGSVLDFMS------ 546

  Fly  1300 HKKYSKSALNDDLSELLTTVKKVPTAE--------TTKLSARHQDEADEERSSRESDGDFKSLSN 1356
            .|.|...:| |.|:.|...|||.|..|        .|||....||.:.:...||.| .:..||||
Zfish   547 MKSYPDMSL-DMLNTLGKCVKKEPEHEDGHQHFDDPTKLLQEFQDASVDRVGSRPS-SNLSSLSN 609

  Fly  1357 SR-------GSSEERPPVAKKGKKAE 1375
            :.       |||    |....|.:||
Zfish   610 ASERDQHHLGSS----PHLGVGDQAE 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246
dikar	NP_001261480.1	Bromo_gcn5_like	892..991	CDD:99941	34/127 (27%)
brd9	XP_005170179.1	Bromo_brd7_like	170..267	CDD:99945	29/96 (30%)
brd9	XP_005170179.1	DUF3512	326..557	CDD:288847	59/309 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D439339at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010