DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dikar and Lpt

DIOPT Version :9

Sequence 1:	NP_001261480.1	Gene:	dikar / 38747	FlyBaseID:	FBgn0261934	Length:	3261	Species:	Drosophila melanogaster
Sequence 2:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster

Alignment Length:	1359	Identity:	240/1359 - (17%)
Similarity:	410/1359 - (30%)	Gaps:	503/1359 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   959 IVNNCRLYNGHNNEYTEMVNNLQDAFEKAT----------KKYFDNLSDDEDD----------DP 1003
            |.::|  |...|..::..:  .|.|:..|:          .|:..:..|:|.|          :|
  Fly   323 ICDSC--YQQRNKGFSCPI--CQKAYRAASHKEMVKCSWCNKFVHSTCDEEADLTAYHKKKEQNP 383

  Fly  1004 NLSYPAADSKMNVFREKYFSKKAKEETEKDAPGRPAVSSAEEDLSEIEAEAPQKAQKRKRKEKDK 1068
            :..|...:.|.|                ...||     |:::.:..|...|...:.::
  Fly   384 DYDYVCPNCKSN----------------SSGPG-----SSQQTIDSIVLSAMDSSSEQ------- 420

  Fly  1069 RRKKKTKSKADVETDDEDMEAEREPTPPPPPPTSKKSKTSKTGKEKEKDKEKEKDKDKEKDKETS 1133
                  .|..::|.|    ..|.:||   ..|:|.:.....|||:                |...
  Fly   421 ------LSLKEIELD----PLEGKPT---MDPSSDELHKLPTGKK----------------KVCL 456

  Fly  1134 SFKRGRKTK-----SDKSASKSSKKTKKGAKKSSADSDPESDPSDSRESEDYSDDDHISLAKTKS 1193
            :..|||..|     ....:..:.|::.:|..:..|.....||...||..|       ..|...|.
  Fly   457 TSVRGRSGKFVLHRMGVMSQINKKRSTRGKGRQLALPTISSDRCLSRSME-------TDLTSDKK 514

  Fly  1194 LVKPTARTIAAQKKK------SVPAESKVKMPTPVK---------------RQVKGKG------- 1230
            |:..:||....|.:.      |:..||...|.|..:               |.:..||
  Fly   515 LLLCSARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVKPSRGILQKGWRCLDCT 579

  Fly  1231 --KGGRKAKDDS--LDSDQSD-------VNVKKQLPPT-----AAAALAESAAELEEDPDDPPPD 1279
              :|..|..|::  |..|:.|       ||...:..||     :...|.:....       .|.:
  Fly   580 VCEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKCGR-------NPTE 637

  Fly  1280 EDEDEDSS-------RSRSMSPF-KVDLHKKYSKSALNDDLSELLTTVKKVPTAETTKLSAR-HQ 1335
            :.|..||:       .|:|..|. ||    .||...:             :...|..:|.|. |.
  Fly   638 KSEFGDSNMLECPSCTSQSSCPVCKV----SYSNGEM-------------IIQCEHCELWAHFHC 685

  Fly  1336 DEADEERSSRESDGD----FK---------SLSNSRGSSEERPPVAKKGKK------AESSKKEK 1381
            |..:.:.:....|.:    ||         ||::::..:|:...:..:|.|      |.|.....
  Fly   686 DSVNAQLTIDHYDNNVYKCFKCRCSTRSTNSLADAKFGNEDSLAITPQGSKPFVHITASSGPSFD 750

  Fly  1382 EKKGRDKDR-----DRDKE----------------------------KDKDKSRSAKDKKSKDES 1413
            .|.|.:::.     |..:.                            |.|.|.|.|.. ..||..
  Fly   751 SKSGAERNHPTLSGDMPESAPEALHWIDGVCLSESGLGMIKSLSTEIKRKRKMRQALG-NGKDGQ 814

  Fly  1414 PVLVAAAEAAAVVQAELDMLLPFMDKY--------------------------DVIKYRRSR--- 1449
              |.||||.|             ::||                          ::::.:|.|
  Fly   815 --LEAAAEEA-------------LEKYKDGMVWDGTENAIPEGFTISINDEGVNILRKKRQRNLQ 864

  Fly  1450 -AAFSGSSASN-SLAPSEDSKSAITKSNR-----ENRKASAKREKS----------PDAVENKRG 1497
             ....|.|..| .|....:..:|:.:.|.     :.:|...|::|:          .:|...|..
  Fly   865 KLGIGGFSVRNRGLKKDSEETTAVDQINSLMTMDKKKKIIRKKQKNKLIEAYPVYLQEAFFGKPL 929

  Fly  1498 RKSKDQKRSKESDKAEKSDKASKADTEKHSEKSKKKEE-------PPKVVEKA------------ 1543
            .:..:...: ::|.:::.|.:.|....:...||...::       |.|.|:|.
  Fly   930 LEGGELVMA-DTDSSDEIDASMKVYFTRPEGKSPANQDTLAVNKSPAKTVKKVKAELKTENKTVF 993

  Fly  1544 --------QREKSPAPVS-------------------ALETIKEPPAP-----TPIATSASGKVK 1576
                    |.:....|||                   .|:.:..|..|     ..::|..|.:|.
  Fly   994 IQQMPMGIQNKNGTTPVSNVFDPLQAEISNTVFANRHPLDALASPNVPELDMANSVSTVPSAEVI 1058

  Fly  1577 EGPAKKEPKKRPDKQMPPPPKPADKSSEK-----GSGKKSSSKKAAQKAGQPQTNNNTNLEAL-- 1634
            |.|.::.|....|..|.|...|.::....     |:...:.:::...:...||..|..|::.:
  Fly  1059 EKPMRESPAVLVDSFMVPNQLPQEQKFHNQLYLGGNTLVNPAQQLQFRQQAPQNANKQNMQTIMS 1123

  Fly  1635 --DVETEQTLKDINRWLEHTPRFTEFSSASNSPSRYNLLDDFDSGIGSKLDA---ADFRRPVALA 1694
              .::||:..::..:.:|..   ||..:|....:...:..|.|.|:.:.:.|   |:...|
  Fly  1124 QVVLQTEKRPEEEQKVVEPV---TETLNAGTQKTAEKMRKDEDLGLMATISAVLYANTEHP---- 1181

  Fly  1695 APKAELVP------TKLAEALNELVSEPKEAVSKSESESVAPTPSSVSSSCGTPPHSMHSGNSIG 1753
             ...||.|      .::.:....|.:|.|....:...::
  Fly  1182 -NLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAKDN-------------------------- 1219

  Fly  1754 STSATAASSSNCSNNSMPTPLPVAVTPTPT---------PAPPPLLPIPKPKEPS---------- 1799
                .:|.......|.:|.|      |.|.         ..||.|    |..:|:
  Fly  1220 ----RSALRQRREQNKIPMP------PKPQKQEEMGRVWKQPPKL----KEDQPNMFVTYNGNAY 1270

  Fly  1800 --------TTQLILNPPPPPHIKQQLAKEAKRKSLKEKQAAQAAQAQQVKAKANVMRTIDRLQPG 1856
                    :.|...|.|.|.|:...:     ..:|..|...|..|.....|....|.|:|
  Fly  1271 DMGNYVGGSAQAASNNPNPHHVMPNV-----NDNLVIKATMQRTQVHTTAASTLKMTTVD----- 1325

  Fly  1857 KAKGNLLQNVVAVKSTEEGGDSHAGVNPVTTKVKELKNALITETCEGAPKLSLGTVLKTQDFSLG 1921
                |.|:...||..||..||            |:|:|.|...:.|  |.| :|.   ..|..||
  Fly  1326 ----NRLELNTAVYGTEPIGD------------KKLRNLLQKNSTE--PML-MGA---NSDLFLG 1368

  Fly  1922 KSLEEMSGKKDANEDDRPNEEASPKNSSPPTTPNTEAPKPFEALHELSKRGKSSEPSKSEASQKE 1986
            ..:..:...::.                 |.|.|...         ||..|| |:||:..:.:::
  Fly  1369 NDVMRLGMMQNT-----------------PITQNNPM---------LSISGK-SQPSEGRSLEQD 1406

  Fly  1987 KPNLSAWLKAFGGPKVSKKSEDEEKQQTPVQDLQG------DSKVAPPAHSPAGDNFSL 2039
                    ...|.|:.:..|. .|.:.....||.|      |..:.....|..||:|::
  Fly  1407 --------VKLGEPQEATSSA-VELENVGFSDLLGGLGEGDDDDLLKSLTSEMGDDFNI 1456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246
dikar	NP_001261480.1	Bromo_gcn5_like	892..991	CDD:99941	7/41 (17%)
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600	9/56 (16%)
		PHD4_KMT2C_like	530..578	CDD:276987	8/47 (17%)
		PHD5_KMT2C_like	580..625	CDD:276988	10/44 (23%)
		PHD6_KMT2C_like	657..707	CDD:276989	12/66 (18%)
		NHP6B	1101..>1237	CDD:227935	26/179 (15%)
		HMG	1173..1231	CDD:197700	9/92 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900