DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dikar and Brd3

DIOPT Version :9

Sequence 1:	NP_001261480.1	Gene:	dikar / 38747	FlyBaseID:	FBgn0261934	Length:	3261	Species:	Drosophila melanogaster
Sequence 2:	XP_006233887.1	Gene:	Brd3 / 362092	RGDID:	1308925	Length:	742	Species:	Rattus norvegicus

Alignment Length:	913	Identity:	205/913 - (22%)
Similarity:	318/913 - (34%)	Gaps:	258/913 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   852 SPTTNPTSTSLLHPVTTNNNSTYNSSNHANILSFTETEEVLQIGMHKVLVYVK---NHRDAWPFV 913
            :||..|.....::|.....::........|.|.:.:.            |.||   .|:.||||.
  Rat     8 APTGIPAVPGPVNPPPPEVSNPSKPGRKTNQLQYMQN------------VVVKTLWKHQFAWPFY 60

  Fly   914 DPVE--EDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEM 976
            .||:  :...|.|:.||:.|||:..::.:|::..|...||...||..:..||.:||...::...|
  Rat    61 QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLM 125

  Fly   977 VNNLQDAF------------------------------EKATKKYFDNLSDDEDDDPNLSYPAAD 1011
            ...|:..|                              :.|..:....:|......|..:.|...
  Rat   126 AQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQNAGAQQMGAVSSVSPAPPFQNIPPTV 190

  Fly  1012 SKMNVFREKYFSKKAKEETEKDAPGRPAVSSAEEDLSEIEAEAPQKAQKRKRKEKDKRRKKKTKS 1076
            |:..|.............|....|...|.......:..:....|...           :||..|.
  Rat   191 SQTPVIAATPVPTITANVTSVPVPPPAAPPPPATPIVPVVPPTPPVV-----------KKKGVKR 244

  Fly  1077 KADVETDDED-MEAEREPTPPP--PPPTSKKSKTSKTGKEKEKDKEKEKDKDKEKDKETSSFKRG 1138
            |||..|.... :.|.|..:|||  .|..:|.....::|....|..:|:.: |.|..:..     |
  Rat   245 KADTTTPTTSAITASRSESPPPLSEPKQAKVVARRESGGRPIKPPKKDLE-DGEVPQHA-----G 303

  Fly  1139 RKTK-SDKSASKSSKKTKKGAKKSSADSDPESDPSDSR--ESEDYSD----DDHISLAKTK--SL 1194
            :|.| |:......|...:..:||.:|.:.|...|.|:.  |..||.|    ...:|..|.|  |.
  Rat   304 KKGKLSEHLRHCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDSR 368

  Fly  1195 VKPTARTIAAQ--------KKKSVPAESKVKMPTPVKRQVKGKGKGGRKAKD------DSLDSDQ 1245
            ..|.|:..||.        .|.:.|....|.|              .||.:|      ..:..:.
  Rat   369 EYPDAQGFAADIRLMFSNCYKYNPPDHEVVAM--------------ARKLQDVFEMRFAKMPDEP 419

  Fly  1246 SDVNVKKQLP-PTA--AAALAESAAELEEDPDDPPPDEDEDEDSSRSRSMSPFKVDLHKKYSKSA 1307
            .:|   ..|| |||  .:..|||:...||...|....:.|:|.::|       ..:|.::....|
  Rat   420 MEV---PALPAPTAPIVSKGAESSRSSEESSSDSGSSDSEEERATR-------LAELQEQTGCGA 474

  Fly  1308 LNDDLSELLTTVKKVPTAETTKLSARHQDEADEERSSRESDGDFKSLSNSRGSSEERPPVAKKGK 1372
            ..|.|..:          .:.:|.|.|:..|              :||.:        ||.|..|
  Rat   475 FQDQLLNV----------SSVQLKAVHEQLA--------------ALSQA--------PVNKPKK 507

  Fly  1373 KAESSKKEKEKKGRDKDRDRDKEKDKDKSRSAKDKKSKDESPVLVAAAEAAAVVQAELDMLLPFM 1437
            |.|  |||||||.:||    :|||:|.|::|.::||:|        ||.||
  Rat   508 KKE--KKEKEKKKKDK----EKEKEKHKAKSEEEKKAK--------AAPAA-------------- 544

  Fly  1438 DKYDVIKYRRSRAAFSGSSASNSLAPSEDSKSAITKSNRENRKASAKREKSPDAVENKRG-RKSK 1501
                             ..|....||::.:.|..|.| |:.:|...:...|.|:.|.:.| ..|.
  Rat   545 -----------------KQAQQKKAPTKKANSTTTAS-RQLKKGGKQASASYDSEEEEEGLPMSY 591

  Fly  1502 DQKRSKESDKAEKSDKASKADTEK-----HSEKSKKKEEPPKVVEKAQREKSPAPVSA-LETIKE 1560
            |:||....|       .::...||     |..:|:         |.:.|:.:|..:.. .||:|
  Rat   592 DEKRQLSLD-------INRLPGEKLGRVVHIIQSR---------EPSLRDSNPDEIEIDFETLK- 639

  Fly  1561 PPAPTPIATSASGKVKEGPAKKEPKKRPDKQMPPPPKPADKSSEKGSGKKSSSKKAAQKAGQPQT 1625
               ||.: ......||....||:            .||...     ||||.::|...:.|.:.:.
  Rat   640 ---PTTL-RELERYVKSCLQKKQ------------RKPLST-----SGKKQAAKSKEELAQEKKK 683

  Fly  1626 NNNTNLEALDVETEQTLKDINRWL---EHTPRFTEFSSASNSPSRYNLLDDFD----SGIGSKLD 1683
                       |.|:.|:|::..|   :.|.:....|:.|..|||.:.....:    |..||..|
  Rat   684 -----------ELEKRLQDVSGQLNSKKPTKKEKSGSAPSGGPSRLSSSSSSESASSSSSGSSSD 737

  Fly  1684 AAD 1686
            ::|
  Rat   738 SSD 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246
dikar	NP_001261480.1	Bromo_gcn5_like	892..991	CDD:99941	31/133 (23%)
Brd3	XP_006233887.1	Bromo_Brdt_I_like	34..140	CDD:99929	32/117 (27%)
		Bromo_Brdt_II_like	311..412	CDD:99930	26/114 (23%)
		BET	588..652	CDD:407211	18/84 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900