DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dikar and Brd2

DIOPT Version :9

Sequence 1:	NP_001261480.1	Gene:	dikar / 38747	FlyBaseID:	FBgn0261934	Length:	3261	Species:	Drosophila melanogaster
Sequence 2:	NP_997660.1	Gene:	Brd2 / 294276	RGDID:	1303324	Length:	798	Species:	Rattus norvegicus

Alignment Length:	890	Identity:	190/890 - (21%)
Similarity:	312/890 - (35%)	Gaps:	280/890 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   896 MHKVLV-YVKNHRDAWPFVDPVE--EDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFR 957
            :|||:: .:..|:.||||..||:  :...|.|:.||::|||:..::.:|::..|...||...||.
  Rat    81 LHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFN 145

  Fly   958 LIVNNCRLYNGHNNEYTEMVNNLQDAF-EKATKKYFDNLSDDEDDDPNLSYPAADSKMNVFREKY 1021
            .:..||.:||...::...|...|:..| :|..                 |.|..:.::.|...|.
  Rat   146 TMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVA-----------------SMPQEEQELVVTIPKN 193

  Fly  1022 FSKK-----AKEETEKDAPGRPAVSSAEEDL-----SEI----------------------EAEA 1054
            ..||     |.:.:...|...|||||.....     .||                      .|..
  Rat   194 SHKKGAKLAALQGSITSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGP 258

  Fly  1055 PQKAQKRKRKEKDKRRKKKTKSKADVETDDEDMEAEREPTP--------PPPPPTSKKSKTSKTG 1111
            |..|.......:...:||..|.|||..|          |||        |..||.|.:.|.::..
  Rat   259 PLLAVSAAPPAQPLAKKKGVKRKADTTT----------PTPTAILAPGSPASPPGSLEPKAARLP 313

  Fly  1112 KEKEKD----KEKEKDKDKEKDKETSSFKRGRKTKSDKSASKSSKKTKKGAKKSSADSDPESDPS 1172
            ..:.:.    |...||....:.:..|| |:|:.::..|..:...|:..  :||.:|.:.|...|.
  Rat   314 PMRRESGRPIKPPRKDLPDSQQQHQSS-KKGKLSEQLKHCNGILKELL--SKKHAAYAWPFYKPV 375

  Fly  1173 DS------------------------------RESEDYSDDDHISLAKTKSLVKPTARTIA-AQK 1206
            |:                              |::::::.|..:..:.......|....:| |:|
  Rat   376 DASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARK 440

  Fly  1207 KKSVPAESKVKMPTPVKRQVKGKGKGGRKAKDDSLDSDQSDVNVKKQLPPTAAAALAESAAE--L 1269
            .:.|......|||                  |:.|  :...:.|...|||..|.:.:||::|  .
  Rat   441 LQDVFEFRYAKMP------------------DEPL--EPGPLPVSTALPPGLAKSSSESSSEESS 485

  Fly  1270 EEDPDDPPPDEDEDEDSSRSRSMSPFKVDLHKKYSKSALNDDLSELLTTVKKVPTAETTKLSARH 1334
            .|...:...:|||:::...|.|....:...|:          |:||                 :.
  Rat   486 SESSSEEEEEEDEEDEEEESESSDSEEERAHR----------LAEL-----------------QE 523

  Fly  1335 QDEADEERSSRESDGDFKSLSNSRGSSEERPPVAKKGKKAESSKKEKEKKGR-DKDRDRDKEKDK 1398
            |..|..|:.:..|.|                |::|..:|.|  ||||:||.: :|.|.|....:.
  Rat   524 QLRAVHEQLAALSQG----------------PISKPKRKRE--KKEKKKKRKAEKHRGRIGIDED 570

  Fly  1399 DKS----RSAKDKKSKDESPVLVAAAEAAAVVQAELDMLLPFMDKYDVIKYRRSRAAFSGSSASN 1459
            ||.    |..:.||||                                      :|...||:|:.
  Rat   571 DKGPRAPRPLQPKKSK--------------------------------------KAGGGGSNATT 597

  Fly  1460 SLAPSEDSKSAITKSNRENRKASAKREKSP-------DAVENKRGR-KSKDQKRSKESDKAEKSD 1516
            ...|...:.:.  .||:..:||   ::.:|       |:.|.:..| .|.|:||....|
  Rat   598 LSHPGFGTSAG--SSNKLPKKA---QKTAPPVLPTGYDSEEEEESRPMSYDEKRQLSLD------ 651

  Fly  1517 KASKADTEK--------HSEKSKKKEEPPKVVEKAQREKSPAPVSALETI------KEPPAPTPI 1567
             .:|...||        .:.:...::..|:.:|.......|:.:..||..      |:|..|..|
  Rat   652 -INKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTI 715

  Fly  1568 ATSASGKVKEGPAKKEPKKRPDKQMPPPPKPADKSSEKGSGKKSSSKKAAQKAGQPQTNNNTNLE 1632
            .... ||.||..|.:  |||          ..:|..:..||:.:|:||..:||.:...::...:.
  Rat   716 RKPV-GKTKEELALE--KKR----------ELEKRLQDVSGQLNSTKKPPKKASEKTESSAQQVA 767

  Fly  1633 ALDVETEQTLKDINRWLEHTPRFTEFSSASNSPSRYNLLDDFDSG 1677
            ...:....:..|              ||:|:|.|..:...|.|||
  Rat   768 VSRLSASSSSSD--------------SSSSSSSSSSSDTSDSDSG 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246
dikar	NP_001261480.1	Bromo_gcn5_like	892..991	CDD:99941	31/98 (32%)
Brd2	NP_997660.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..72
		Bromo_Brdt_I_like	73..179	CDD:99929	31/114 (27%)
		PHA03247	<215..332	CDD:223021	28/126 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..348		22/91 (24%)
		Bromo_Brdt_II_like	348..449	CDD:99930	15/102 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..648		61/282 (22%)
		Nuclear localization signal. /evidence=ECO:0000255	553..557		2/3 (67%)
		BET	639..701	CDD:407211	13/68 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..798		16/76 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000