DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dikar and CECR2

DIOPT Version :9

Sequence 1:NP_001261480.1 Gene:dikar / 38747 FlyBaseID:FBgn0261934 Length:3261 Species:Drosophila melanogaster
Sequence 2:NP_001276976.1 Gene:CECR2 / 27443 HGNCID:1840 Length:1464 Species:Homo sapiens


Alignment Length:2452 Identity:432/2452 - (17%)
Similarity:695/2452 - (28%) Gaps:1122/2452 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 GLLDIQSWWEIPCISHFCSLFSSAFDLPDIDIEDLESALLSDGTSDEDQVALVPELIVRLLKGCD 71
            ||.:::||||:|.|:||||||.:||.|||.:||:||:||      ..|.|..:.:||..||:|| 
Human    10 GLGELRSWWEVPAIAHFCSLFRTAFRLPDFEIEELEAAL------HRDDVEFISDLIACLLQGC- 67

  Fly    72 ALQTVAKEITHSNYQMFLRRFLRQQCRLHQTENHFDTDIDFQSLPVRKRLHILHDLCHFRLDSVD 136
               ...::||...:..:|...:..:..|.:.:.:...:..||.||:|.|:.|||.||.:|||:.|
Human    68 ---YQRRDITPQTFHSYLEDIINYRWELEEGKPNPLREASFQDLPLRTRVEILHRLCDYRLDADD 129

  Fly   137 VQVILSNLEADSLRVEPLGYDAKNSGYWYFYGTRLYRED----KATGGSASSSSGSGSGGAGAST 197
            |..:|..|:||||||||||.|...:.||||||||:|:||    |:.|..:.|....|.....:..
Human   130 VFDLLKGLDADSLRVEPLGEDNSGALYWYFYGTRMYKEDPVQGKSNGELSLSRESEGQKNVSSIP 194

  Fly   198 GGASNSKG------------------------------IGSNGT---VWQVICFTEEDWQNLAAK 229
            |.....:|                              .||.|.   .|.::|.|||:|:.:...
Human   195 GKTGKRRGRPPKRKKLQEEILLSEKQEENSLASEPQTRHGSQGPGQGTWWLLCQTEEEWRQVTES 259

  Fly   230 FKTSTNAKERELFNILDDNFLPKLPQLFRERERLRRRKLLQVRNSSRIRNIAELKARQEEERQRR 294
            |:..|:.:||:|:.:|.::|||::..:.                            .|:.:|.:|
Human   260 FRERTSLRERQLYKLLSEDFLPEICNMI----------------------------AQKGKRPQR 296

  Fly   295 ERENLYQDRQNAHWLAPPQQQQQQQQQQQQQQQQSQQRTRRRSQSTSTASGISTYASSLRRTTTT 359
            .:..|:....:.|....|.:|::.....:.::|:.                              
Human   297 TKAELHPRWMSDHLSIKPVKQEETPVLTRIEKQKR------------------------------ 331

  Fly   360 NSSEFLCHRETFCLSPENDEDDDDDDEALDAEQQSDQPEQQRQQEEQPPEEEQRQEPEELLAVSA 424
                               ::::::.:.|.|.|:.:|        ||..:||:::|.||  .|.|
Human   332 -------------------KEEEEERQILLAVQKKEQ--------EQMLKEERKRELEE--KVKA 367

  Fly   425 TDDDFRSPEAPKSQTPAELKSKSSHHHHHHHHKKKKSSKKQKKRHHR----DKGRERDREHHHHH 485
            .:|                                 .:|::|.|..|    .:|:|         
Human   368 VED---------------------------------RAKRRKLREERAWLLAQGKE--------- 390

  Fly   486 RRRHKHASEADEGEDDNNNHNSNSNSNSNTNSISSNNSVQPKRRRSGQQQQHHQQAETTEPSTSL 550
                                                                            |
Human   391 ----------------------------------------------------------------L 391

  Fly   551 SPEDKENFCRQLQLLDTNSAAIAVATSIADLSLPSPVAHESETEQDEQVDQPAVVEAQPPALTSA 615
            .||        |..||.|                ||:..|.:|:...::|               
Human   392 PPE--------LSHLDPN----------------SPMREEKKTKDLFELD--------------- 417

  Fly   616 MAPAANVKLPGRQTNNSLSSLTGNIFIPSGSAQQQQQQSQEPPSSSSSSQSGTTTTASTVRSKKQ 680
                                                                             
Human   418 ----------------------------------------------------------------- 417

  Fly   681 KAVLNSSGSSSTSKMADKADRNLSKTETTGKSKKSAAGSSASSSSSKAERISGAYSDKSGDDHVN 745
                                                                        ||   
Human   418 ------------------------------------------------------------DD--- 419

  Fly   746 SSNRSTTNNNSSLNNNNNHKHAPHHSHNNNNNSHSTTTSATTTATTTTSQGYHYNSNLNHNQNHQ 810
                                                                             
Human   420 ----------------------------------------------------------------- 419

  Fly   811 NSHSHHTHHHHHHHHHTTNNHSNKHKTKSHHSLAHNNNNNNSPTTNPTSTSLLHPVTTNNNSTYN 875
                                                                             
Human   420 ----------------------------------------------------------------- 419

  Fly   876 SSNHANILSFTETEEVLQIGMHKVLVYVKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDK 940
                     ||        .|:|||..||.|:|:|||::||:|..||.||.||:.|||:..||.|
Human   420 ---------FT--------AMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKK 467

  Fly   941 LDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMVNNLQDAFEKATKKYFDNLSDDEDDDPNL 1005
            |:.|.|....||.||.:.:..|||.|||.::|||:|.:||:..|.:|..|:|.  .:|.|.|   
Human   468 LNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERCFHRAMMKHFP--GEDGDTD--- 527

  Fly  1006 SYPAADSKMNVFREKYFSKKAKEETEKDAPGRPAVSSAEEDLSEIEAEAPQKAQKRKRKEKDKRR 1070
                         |:::.:    |.||                                 ::|||
Human   528 -------------EEFWIR----EDEK---------------------------------REKRR 542

  Fly  1071 KKKTKS-KADVETDDEDMEAEREPTPPPPPPTSKKSKTSKTGKEKEKDKEKEKDKDKEKDKETSS 1134
            .:..:| .:.|.|...|           |..:|:|.:..:.|                 .|....
Human   543 SRAGRSGGSHVWTRSRD-----------PEGSSRKQQPMENG-----------------GKSLPP 579

  Fly  1135 FKRGRKTKSDKSASKSSKKTKKGAKKSSADSDP---ESDPSDSRESEDYSDDDHISLAKTKSLVK 1196
            .:|...:..|:|:|.:....:.|.......|.|   ...||.:.           .|.:.:..|.
Human   580 TRRAPSSGDDQSSSSTQPPREVGTSNGRGFSHPLHCGGTPSQAP-----------FLNQMRPAVP 633

  Fly  1197 PTARTIAAQKKKSVPAESKVKMPTPVKRQVKGKGKGGRKAKDDSLDSDQSDVNVKKQLPPTAAAA 1261
            .|...:......::...|.|..|.|        |:..::.:..::.            ||....:
Human   634 GTFGPLRGSDPATLYGSSGVPEPHP--------GEPVQQRQPFTMQ------------PPVGINS 678

  Fly  1262 LAESAAELEEDPDDPPPDEDEDEDSSRSRSMSPFKVDLHKKYSKSALNDDLSELLTTVKKVPTAE 1326
            |        ..|....|:|.:                         :...|:.|........:.:
Human   679 L--------RGPRLGTPEEKQ-------------------------MCGGLTHLSNMGPHPGSLQ 710

  Fly  1327 TTKLSARHQDEADEERSSRESDGDFKS--LSNSRGSSEERPPVAKKGKKAESSKKEKEKKGRDKD 1389
            ..::|...||      .|..:...|:.  :....|.:..|||     ...|||:           
Human   711 LGQISGPSQD------GSMYAPAQFQPGFIPPRHGGAPARPP-----DFPESSE----------- 753

  Fly  1390 RDRDKEKDKDKSRSAKDKKSKDESPVLVAAAEAAAVVQAELDMLLPFMDKYDVIKY--RRSRAAF 1452
                                                        :|....|...||  |...|.:
Human   754 --------------------------------------------IPPSHMYRSYKYLNRVHSAVW 774

  Fly  1453 SGSSASNSLAPSEDSKSAITKSNRENRKASAKREKSPDAVENKRGRKSKDQKRSKESDKAEKSDK 1517
            :|:..:.:..|                       ..||                           
Human   775 NGNHGATNQGP-----------------------LGPD--------------------------- 789

  Fly  1518 ASKADTEKHSEKSKKKEEPPKVVEKAQREKSPAPVSALET--------IKEPPAPTPIATSASGK 1574
                            |:|         ...|.|.....|        :..||.|....|..||.
Human   790 ----------------EKP---------HLGPGPSHQPRTLGHVMDSRVMRPPVPPNQWTEQSGF 829

  Fly  1575 VKEG-PAK---KEPKKRPDKQMPPPPKPADKSSEKGSGKKSSSKKAAQKAGQPQTNNNTNLEALD 1635
            :..| |:.   :.|.|....::.|||.||..|.   .|..:.:.:..|  |.....::..:.|:.
Human   830 LPHGVPSSGYMRPPCKSAGHRLQPPPVPAPSSL---FGAPAQALRGVQ--GGDSMMDSPEMIAMQ 889

  Fly  1636 VETEQTLKDINRWLEHTPRFTE----FSSASNSPSRYNLLDDFDSGIGSKLDAADFRRPVALAAP 1696
            ..:.:.......:..|.|....    |...::..|                        |.::||
Human   890 QLSSRVCPPGVPYHPHQPAHPRLPGPFPQVAHPMS------------------------VTVSAP 930

  Fly  1697 KAEL-VPTKLAEALNELVSEPKEAVSKSESESVAPTPSSVSSSCGTPPHSMHSGNSIGSTSATAA 1760
            |..| .|.:..|  |....||       |::...|.|.....    ||       .:|::..   
Human   931 KPALGNPGRAPE--NSEAQEP-------ENDQAEPLPGLEEK----PP-------GVGTSEG--- 972

  Fly  1761 SSSNCSNNSMPTPLPVAVTPTPTPAPPPLLPIPKPKEPSTTQLILNPPPPPHIKQQLAKEAKR-K 1824
                           |.:|..|.|.||......:...|...:.:     .|.:|...::.|.. |
Human   973 ---------------VYLTQLPHPTPPLQTDCTRQSSPQERETV-----GPELKSSSSESADNCK 1017

  Fly  1825 SLKEKQAAQAAQAQQVKAKANVMRTIDRLQPGKAKGNLLQNVVAVKSTEEGGDSHAGV----NPV 1885
            ::|.|....:                |...||.|....::::..|  .:.|..|..||    :|.
Human  1018 AMKGKNPWPS----------------DSSYPGPAAQGCVRDLSTV--ADRGALSENGVIGEASPC 1064

  Fly  1886 TTKVKELKNALITETCEGAPKLSLGTVLKTQDFSLGKSLEEMSGKKDANEDDRPNEEASPKNSSP 1950
            .::.|.|.::       |:.||..         ..|::|:|.......|       .|:|.::.|
Human  1065 GSEGKGLGSS-------GSEKLLC---------PRGRTLQETMPCTGQN-------AATPPSTDP 1106

  Fly  1951 PTTPNTEAPKPFEALHELSKRGKSSEPSKSEASQKEKPNLSAWLKAFGGPKVSKKSEDEEKQQTP 2015
            ..|..|.:..|...:..|       |...|.|.....|.|..     .||.:..||.....|..|
Human  1107 GLTGGTVSQFPPLYMPGL-------EYPNSAAHYHISPGLQG-----VGPVMGGKSPASHPQHFP 1159

  Fly  2016 VQDLQGDSKVAPPAHSPAGDNFSLPTVMR--------------QRKP----------------ST 2050
            .:..|.:.     .||.....:..|..||              ||.|                ..
Human  1160 PRGFQSNH-----PHSGGFPRYRPPQGMRYSYHPPPQPSYHHYQRTPYYACPQSFSDWQRPLHPQ 1219

  Fly  2051 GSTNSERSSFSQDPDSPRIAIDERYGSYAA-------GSYTSPIGASPIGASPIMVSPKPNDDMG 2108
            ||.:...:|   .|..||....::....:.       .:.|||.....:.|.      .|||.. 
Human  1220 GSPSGPPAS---QPPPPRSLFSDKNAMASLQGCETLNAALTSPTRMDAVAAK------VPNDGQ- 1274

  Fly  2109 KPASPYPLNGAIKVGFYQDTTTKSSPDKSCSPREMNSPYPQYSQHIYSSASSPNVSTPD-MSGTS 2172
               :|.|          ::.....|.::..||:|    :.....|..::....::|..: :.||.
Human  1275 ---NPGP----------EEEKLDESMERPESPKE----FLDLDNHNAATKRQSSLSASEYLYGTP 1322

  Fly  2173 P-----YGGGNSYNPSGSEASKT-PAYSSTSPLPIYDQYKQPRSQESDYNSSMSPSTPNPHSPYQ 2231
            |     .|.|:|..|..|...:| |.|:...|.    .:.|||:    |:|.:: :.| ||.|  
Human  1323 PPLSSGMGFGSSAFPPHSVMLQTGPPYTPQRPA----SHFQPRA----YSSPVA-ALP-PHHP-- 1375

  Fly  2232 QPQSSPYTTPQQSQSTHPSPYHNQSP-YHQQQHSPYHPPAAQQQQQSS--------QPSHSPAAH 2287
                         .:|.|:....:.| |..|:....|..|...:|..:        |..:.|:..
Human  1376 -------------GATQPNGLSQEGPIYRCQEEGLGHFQAVMMEQIGTRSGIRGPFQEMYRPSGM 1427

  Fly  2288 QQALSPMHSVESPASSAATQPPTPLAQSPAEQQHSPYQQPVLSPYQQ 2334
            |     ||.|:|.||.    |.||.| :.::::..|::.|.| |..|
Human  1428 Q-----MHPVQSQASF----PKTPTA-ATSQEEVPPHKPPTL-PLDQ 1463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dikarNP_001261480.1 WHIM1 100..148 CDD:292246 19/47 (40%)
Bromo_gcn5_like 892..991 CDD:99941 47/98 (48%)
CECR2NP_001276976.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 170..241 9/70 (13%)
WHIM3 244..284 CDD:292248 14/39 (36%)
Bromo_gcn5_like 418..518 CDD:99941 51/249 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..684 35/247 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 776..805 8/103 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 899..1033 34/216 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1145..1239 19/101 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1267..1300 10/56 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1422..1464 17/53 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 95 1.000 Domainoid score I7441
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007388
OrthoInspector 1 1.000 - - oto91210
orthoMCL 1 0.900 - - OOG6_106343
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5612
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.930

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