DRSC/TRiP Functional Genomics Resources

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Protein Alignment dikar and BRD4

DIOPT Version :9

Sequence 1:NP_001261480.1 Gene:dikar / 38747 FlyBaseID:FBgn0261934 Length:3261 Species:Drosophila melanogaster
Sequence 2:NP_001366220.1 Gene:BRD4 / 23476 HGNCID:13575 Length:1362 Species:Homo sapiens


Alignment Length:1832 Identity:374/1832 - (20%)
Similarity:588/1832 - (32%) Gaps:680/1832 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   851 NSPTTNPTSTSLLHPVTTNNNSTYNSSNHANILSFTETEEVLQIGMHKVLVYVKNHRDAWPFVDP 915
            |:.:|||..     |.|:|.|.....:|.            ||..:..||..:..|:.||||..|
Human    39 NAASTNPPP-----PETSNPNKPKRQTNQ------------LQYLLRVVLKTLWKHQFAWPFQQP 86

  Fly   916 VE--EDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMVN 978
            |:  :...|.||.||:.|||:..::.:|::..|....|...||..:..||.:||...::...|..
Human    87 VDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAE 151

  Fly   979 NLQDAFEKATKKYFDNLSDDEDDDPNLSYPAADSKMNVFREKYFSKKAKEETEKDAPGRPAVSSA 1043
            .|                                      ||.|.:|..|           :.:.
Human   152 AL--------------------------------------EKLFLQKINE-----------LPTE 167

  Fly  1044 EEDLSEIEAEAPQKAQKRKRKEKDKRRKKKTKSKADVETDDEDMEAEREP---TPPPPPPTSKKS 1105
            |.::..::|           |.:.:.||:...:|..|.|.....:|...|   ||.|.||     
Human   168 ETEIMIVQA-----------KGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPP----- 216

  Fly  1106 KTSKTGKEKEKDKEKEKDKDKEKDKETSSFKRGRKTKSDKSASKSSKKTKKGAKKSSADSDPESD 1170
                                                                    ...:.|...
Human   217 --------------------------------------------------------PVQATPHPF 225

  Fly  1171 PSDSRESEDYSDDDHISLAKTKSLVKP----TARTIAAQ-KKKSVPAESKVKMPTPV----KRQV 1226
            |:.:        .|.|......::|.|    |...:..| :....||...|:...|:    .:.|
Human   226 PAVT--------PDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPV 282

  Fly  1227 KGKGKGGRKAKDDSLDSDQSDVNVKKQLPP----TAAAALAESAAELEEDPDDPP----PDEDED 1283
            |.| ||.::..|.:..:....::....|||    |......||:.     |..||    ||..:.
Human   283 KTK-KGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSR-----PVKPPKKDVPDSQQH 341

  Fly  1284 EDSSRSRSMS-----------------------PFKVDLHKKYSKSALN-DDLSEL------LTT 1318
            ....:|..:|                       ||    :|.....||. .|..::      ::|
Human   342 PAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPF----YKPVDVEALGLHDYCDIIKHPMDMST 402

  Fly  1319 VKKVPTAETTKLSARHQDEADEERSSRESDGDFKSLSNSRGSSEERPP---VAKKGKKAESSKKE 1380
            :|       :||.||      |.|.::|...|.:.:.::  ..:..||   |....:|.:     
Human   403 IK-------SKLEAR------EYRDAQEFGADVRLMFSN--CYKYNPPDHEVVAMARKLQ----- 447

  Fly  1381 KEKKGRDKDRDRDKEKDKDKSRSAKDKKSKDESPVLVAAAEAAAVVQAELDMLLPFMDKYDVIKY 1445
                            |..:.|.|| ...:.|.||:..::.|   |.....::.|          
Human   448 ----------------DVFEMRFAK-MPDEPEEPVVAVSSPA---VPPPTKVVAP---------- 482

  Fly  1446 RRSRAAFSGSSASNSLAPSEDSKSAITKSNRENRKASAKREKSPDAVENKRGRKSKDQKRSKESD 1510
                    .||:.:|...|.||.|:...|..|..:..|:.::...||..:....|:.|:     :
Human   483 --------PSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQ-----N 534

  Fly  1511 KAEKSDKASKADTEKHSEKSKKKEEPPKVVEKAQREKSPAPVSALETIKEPPAPTPIATSASGKV 1575
            |.:|.:|..|   ||..||.|:|||    ||:.::.|:          ||||   |..|..:...
Human   535 KPKKKEKDKK---EKKKEKHKRKEE----VEENKKSKA----------KEPP---PKKTKKNNSS 579

  Fly  1576 KEGPAKKEPKKRPDKQMPPPPKPADKS--------SEKGSGKKSSSKKAAQKAG---------QP 1623
            ....:||||  .|.|..|||...:::.        .||.......:|...:|.|         :|
Human   580 NSNVSKKEP--APMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREP 642

  Fly  1624 Q-TNNNTNLEALDVET--EQTLKDINRWLEHTPRFTEFSSASNSPSRYNLLDDFDSGIGSKLDAA 1685
            . .|:|.:...:|.||  ..||:::.|::                         .|.:..|    
Human   643 SLKNSNPDEIEIDFETLKPSTLRELERYV-------------------------TSCLRKK---- 678

  Fly  1686 DFRRPVALAAPKAELVPTKLAEALNELVSEPKEAVSKSESESVAPTPSSVSSSCGT--PPHSMHS 1748
              |:|   .|.|.:::..          |...:..|.|||||.:.:.||.|....|  .|.|...
Human   679 --RKP---QAEKVDVIAG----------SSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKK 728

  Fly  1749 GNSIGSTSATAASSSNCSNNSMPTPLPVAVTPTPTPAPPPLLPIPKPKEPSTTQLILNPPPPPHI 1813
            |:. |..........:......|.|:|      ..|.|||..| |.|..|...|....|||||.:
Human   729 GHP-GREQKKHHHHHHQQMQQAPAPVP------QQPPPPPQQP-PPPPPPQQQQQPPPPPPPPSM 785

  Fly  1814 KQQLAKEAKRKSLKEKQAAQAAQAQQVKAKANVMRTIDRLQPGKA---KGNLLQNVVAV------ 1869
            .|              |||.|.::......|..:..::...||..   .|:..|.::.:      
Human   786 PQ--------------QAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELP 836

  Fly  1870 --------KSTEEGGDSHAGVNPVTTKVKELKNALITETCEGAPKLSLGTVLKTQDFSLGKSLEE 1926
                    .||....:.||.|:|     ..|.|||                              
Human   837 PHLPQPPEHSTPPHLNQHAVVSP-----PALHNAL------------------------------ 866

  Fly  1927 MSGKKDANEDDRPNEEAS---PKNSSPPTTPNTEAPKPFEALHELSKRGKSSEPSKSEASQKEKP 1988
                  ..:..||:..|:   ||.:.||..                      .|:.::.....:|
Human   867 ------PQQPSRPSNRAAALPPKPARPPAV----------------------SPALTQTPLLPQP 903

  Fly  1989 NLSAWLKAFGGPKVSKKSEDEEKQQTPVQDLQGD------SKVAPPAHSPAGDNFSLPTVMRQRK 2047
            .::.      .|:|  ..||||....|:..:|..      .||.||  :|.     ||:|..|.:
Human   904 PMAQ------PPQV--LLEDEEPPAPPLTSMQMQLYLQQLQKVQPP--TPL-----LPSVKVQSQ 953

  Fly  2048 PSTGSTNSERSSFSQDPDSPRIAIDERYGSYAAGSYTSPIGASPIGASPIMVSPKPNDDMGKPAS 2112
            |                                                    |.|     .|..
Human   954 P----------------------------------------------------PPP-----LPPP 961

  Fly  2113 PYPLNGAIKVGFYQDTTTKSSPDKSCSPREMNSPYP--------QYSQHIYSSASSPNVSTPDMS 2169
            |:|   :::....|.......|.....|::.:.|.|        |:|.||.        ..|...
Human   962 PHP---SVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQ--------QPPPPQ 1015

  Fly  2170 GTSPYGGGNSYNPSGSEASKTPAYSSTSPLPIYDQYKQPRSQESD-YNSSMSPSTPNP---HSPY 2230
            |..|     .:.|.|.:   .|......|..:...:..||..:|| |::......|:|   |||.
Human  1016 GQQP-----PHPPPGQQ---PPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQ 1072

  Fly  2231 QQPQSSPYTTPQQSQS-THPS-PYHNQSPYHQQQHSPYHPPAAQQQQQ-----SSQPSHSPAAHQ 2288
            .          .|.|| ||.| |..|..|..|:..:     |:..|.|     ..:..|||....
Human  1073 M----------SQFQSLTHQSPPQQNVQPKKQELRA-----ASVVQPQPLVVVKEEKIHSPIIRS 1122

  Fly  2289 QALSPMHSVESPASSAATQPPTPLAQSPAEQQHSPYQQPVLSPYQQPQQQVQPPVVP-------- 2345
            :..||....|.|....:.:.|..|.|.| |.:.....:||:.|   |:|...||..|        
Human  1123 EPFSPSLRPEPPKHPESIKAPVHLPQRP-EMKPVDVGRPVIRP---PEQNAPPPGAPDKDKQKQE 1183

  Fly  2346 ---PVQPSAGAQASTALGNNGYAPTHDSYQQLQQQQRSLYNPATLINPLSTAASSTASITKPNND 2407
               ||.|    :....:.|.|      |:..|.|:     :|.|   |.|||.||:.|..:    
Human  1184 PKTPVAP----KKDLKIKNMG------SWASLVQK-----HPTT---PSSTAKSSSDSFEQ---- 1226

  Fly  2408 WSLNRSLLPPSITNTVNQAAQQQQQQQQQQAGQLQQQPQMQAAQQQLQSTPQQQQQQLQGTPQQQ 2472
                           ..:||::::::::....|.:.      |:::.:...|::.:..:.....:
Human  1227 ---------------FRRAAREKEEREKALKAQAEH------AEKEKERLRQERMRSREDEDALE 1270

  Fly  2473 QLQGSQQQQQQQQQQQQLQTSQQQQQQVLGHQQQHKPKYPTYAQYQSTNAAANAAAAADAVDNLQ 2537
            |.:.:.::.:::|:|||.|..:|||||    |||               |||.||||.....:.|
Human  1271 QARRAHEEARRRQEQQQQQRQEQQQQQ----QQQ---------------AAAVAAAATPQAQSSQ 1316

  Fly  2538 -----QQQQKIA 2544
                 .||:::|
Human  1317 PQSMLDQQRELA 1328

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dikarNP_001261480.1 WHIM1 100..148 CDD:292246
Bromo_gcn5_like 892..991 CDD:99941 30/100 (30%)
BRD4NP_001366220.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58 8/23 (35%)
Bromo_Brdt_I_like 58..164 CDD:99929 36/166 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 174..229 16/126 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 242..352 26/115 (23%)
Bromo_Brdt_II_like 353..454 CDD:99930 21/140 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 463..615 49/199 (25%)
NPS region 484..503 7/18 (39%)
BID region 524..579 23/79 (29%)
BET 609..673 CDD:407211 14/88 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 674..1100 125/635 (20%)
PRK03427 <809..>922 CDD:235124 29/183 (16%)
C-terminal (CTD) region 1047..1362 89/363 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1116..1339 67/279 (24%)
BRD4_CDT 1319..1362 CDD:407248 3/10 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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