DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dikar and Baz1b

DIOPT Version :9

Sequence 1:	NP_001261480.1	Gene:	dikar / 38747	FlyBaseID:	FBgn0261934	Length:	3261	Species:	Drosophila melanogaster
Sequence 2:	NP_035844.2	Gene:	Baz1b / 22385	MGIID:	1353499	Length:	1479	Species:	Mus musculus

Alignment Length:	1537	Identity:	275/1537 - (17%)
Similarity:	480/1537 - (31%)	Gaps:	461/1537 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 ENDEDDDDDDEALDAEQQSDQPEQQRQQEEQPPEEEQRQEPEELLAVSATDDDFRSP-EAPKSQT 439
            |...|...|..:.|.|..|...:..:::|....|:|.|:|       |..|...||| :.|.|..
Mouse   149 EKKSDGACDSPSSDKENSSQMAQDLQKKETVVKEDEGRRE-------SINDRARRSPRKLPTSLK 206

  Fly   440 PAELKSKSSHHHHHHHHKKKKSSKK--------QKKRHHRDKGRERDREHHHHHRRRHKHASEAD 496
            ..|.|........|.:..|.::..|        ...|..|...:|..|....|:..|......|.
Mouse   207 KGERKWAPPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNKEILRYFIRHNALRAGTGENAP 271

  Fly   497 EGEDDN--NNHNSNSNSNSNTNSISSNNSVQP--KRRRSGQQQQHHQQAETTEPSTSLSPEDKEN 557
            ...:|.  ..::..|..:..........::.|  |||.:|...:...:....:.|:..||.:.:.
Mouse   272 WVVEDELVKKYSLPSKFSDFLLDPYKYMTLNPSTKRRNTGSPDRKPSKKPKRDSSSLSSPLNPKL 336

  Fly   558 FCRQLQLLDTNSAAIAVATSIADLSLPSPVAHESETEQDEQVDQPAVVEAQPPALTSAMAPAANV 622
            :|........|...:.|..|            ::....:|.::          .:...|:|
Mouse   337 WCHVHLEKSLNGPPLKVKNS------------KNSKSPEEHLE----------GVMKIMSP---- 375

  Fly   623 KLPGRQTNNSLSSLTGNIFIP-SGSAQQQQQQSQEPPSSSSSSQSGTTTTASTVRSKKQKAVLNS 686
                  .||.|.|    ..|| .|.|.::..:..:.|..:..               :.|.:||.
Mouse   376 ------NNNKLHS----FHIPKKGPAAKKPGKHSDKPLKAKG---------------RGKGILNG 415

  Fly   687 SGSSSTSKMADKADRNLSKTETTGKSKKSAAGSSASSSS--SKAERISGAYSDKSGDDHVN---- 745
            ..|:..||...|.    .||..| |.|:......|..:.  ::..|.||.....||..|.:
Mouse   416 QKSTGNSKSPSKC----VKTPKT-KMKQMTLLDMAKGTQKMTRTPRSSGGVPRSSGKPHKHLPPA 475

  Fly   746 --------SSNRSTTNNNSSLN----------NNNNHKHAPHHSHNNNNNSHSTTTSATTTATTT 792
                    ..|:...:..|:|:          :|.:....|..........:.........|:.:
Mouse   476 ALHLIAYYKENKDKEDKKSALSCVISKTARLLSNEDRARLPEELRALVQKRYELLEHKKRWASMS 540

  Fly   793 TSQGYHYNSNLNHNQNHQNSHSHHTHHHHHHHHHTTNNHSNKHKTKSHHSLAHNN--------NN 849
            ..|...|     ..:..|.......................|.|......|...|        ..
Mouse   541 EEQRKEY-----LKKKRQELKERLREKAKERREREMLERLEKQKRFEDQELGGRNLPAFRLVDTP 600

  Fly   850 NNSPTTNPTSTSLL----------------HPVTTNNNSTYNSSNHANILSFTETEEVLQIGMHK 898
            ...|.|.....:|:                :|:|..:.....|::..   .|.....||.|.:..
Mouse   601 EGLPNTLFGDVALVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKG---GFLYLNRVLVILLQT 662

  Fly   899 VLVYVKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNC 963
            :|            .|.:.||.......:...|:.|            |..||.   .||.:..|
Mouse   663 LL------------QDEIAEDYGELGMKLSEIPLTL------------HSVSEL---VRLCLRRC 700

  Fly   964 RLYNGHNNEYTE--------MVNNLQDAF-EKATKKYFDNLSDDEDDDPNLSYPAADSKMNVFRE 1019
            .:........|:        ..|.:||.| ||.....|..|:.:|             |:.:...
Mouse   701 DVQEDSEGSETDDNKDSTPFEDNEVQDEFLEKLETSEFFELTSEE-------------KLRILTA 752

  Fly  1020 ------KYFSKKAKEETEKDAPGRPAVSSAE---EDLSEIEAEAPQK-AQKRKRKEKDKRRKK-- 1072
                  ..:|.:...||.:..       |||   |.|:.::.|..:| |:|:||||.:.|.|:
Mouse   753 LCHRILMTYSVQDHMETRQQV-------SAELWKERLAVLKEENDKKRAEKQKRKEMEARNKENG 810

  Fly  1073 -------KTKSKADVETDDEDMEAEREPTPPPPPPTSKKSK--TSKTGKEKEKDKEKEKDKDKEK 1128
                   |...|.::...::.:|.|.:..     .::.||:  .|...|.|.:.:|:|.....|:
Mouse   811 KEENVLGKVDRKKEIVKIEQQVEVEADDM-----ISAVKSRRLLSMQAKRKREIQERETKVRLER 870

  Fly  1129 DKETSSFKRGRKTKSDKSASKSSKKTKKGAKKSSADSDPES------------------------ 1169
            :.|....:: .|..::|:..:...|.|...:::...:|...
Mouse   871 EAEEERMRK-HKAAAEKAFQEGIAKAKLVLRRTPIGTDRNHNRYWLFSNEVPGLFIEKGWVHNSI 934

  Fly  1170 DPSDSRESEDYS---DDDHISLAKTKSLVKPTARTIAAQKKKSVPAESKVKMPTPVKRQVKGKGK 1231
            |.......:|:|   |||:...:|..:|.|.     |:......||...|:...|         |
Mouse   935 DYRFKHHRKDHSNLPDDDYCPRSKKANLGKN-----ASVNAHHGPALEAVETTVP---------K 985

  Fly  1232 GGRKAKDDSLDSDQSDVNVKKQLPPTAAAALAESAAELEEDPDDPPPDEDEDEDSSRSRSMSPFK 1296
            .|:.                       ...|.:|..||:|......|....:         |..|
Mouse   986 QGQN-----------------------LWFLCDSQKELDELLSCLHPQGIRE---------SQLK 1018

  Fly  1297 VDLHKKYSK-------------------------SALNDDLSELLTTVKK--VPTAETTKLSARH 1334
            ..|.|:|.:                         :.|..||.|:.|.::|  :...|.|
Mouse  1019 ERLEKRYQEITHSIYLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYMEGT------ 1077

  Fly  1335 QDEADEERSSRESDGDFKSLSNSRGSSEERPPVAKKGKKAESSKKEKEKKGRDKDRDRDKEKDKD 1399
             .|.:....|.|...||.....:..:|     |.||..:...:.|:|::|.:.:|..:.:|.|
Mouse  1078 -SEFEARVISLEKLKDFGECVIALQAS-----VIKKFLQGFMAPKQKKRKLQSEDSTKSEEVD-- 1134

  Fly  1400 KSRSAKDKKSKDESPVLVAAAE-AAAVVQAE----LDMLLPFMD---KYDVIKYRRSRAAFSGSS 1456
                 ::||..:|:.|..|..: ..|:.:|:    :.:||..:|   |:|:             |
Mouse  1135 -----EEKKMVEEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDM-------------S 1181

  Fly  1457 ASNSLA-----PSEDSKSAITKSNRENRKA-------SAKRE-----------KSPDAVENKRGR 1498
            |.|:..     ..||.|..:..   |..||       .|..|           :.|.|..|.|||
Mouse  1182 AENARCKVCRKKGEDDKLILCD---ECNKAFHLFCLRPALYEVPDGEWQCPACQPPTARRNSRGR 1243

  Fly  1499 KSKDQKRSKESDKAEKSDKASKADTEKHSEKSKKKEEPPKVVEKAQREKSPAPVSALETIKEPPA 1563
            ...::..|:.|:..|..::      |:..|:.:::||..:|.....|.:        :||:
Mouse  1244 NYTEESTSEGSEGDESGEE------EEEEEEEEEEEEDYEVAGLRLRPR--------KTIR---- 1290

  Fly  1564 PTPIATSASGKVKEGPAKKEPKKRPDKQMPPPPKPADKSSEKGSGKKSSSKKAAQKAGQP----- 1623
                          |.....|..||.:    ||           ||||...:.::....|
Mouse  1291 --------------GKQSVIPAARPGR----PP-----------GKKSHPARRSRPKDDPEVDDL 1326

  Fly  1624 --QTNNNTNLEALDVE-TEQTLKDINRWLEHTPRFTEFSSASNSPSRYNLLD---DFDSGIGSKL 1682
              ||...:..::|::: .|..|..:.::....| |.|..:...:...|::::   ||.: |.:|.
Mouse  1327 VLQTKRISRRQSLELQKCEDILHKLVKYRFSWP-FREPVTRDEAEDYYDVIEHPMDFQT-IQNKC 1389

  Fly  1683 DAADFRRPVALAAPKAELVPTKLAEALNELVSEPKEAVSKSE 1724
            ...::|                   ::.|.:::.|:..:.:|
Mouse  1390 SCGNYR-------------------SVQEFLTDMKQVFANAE 1412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246
dikar	NP_001261480.1	Bromo_gcn5_like	892..991	CDD:99941	21/107 (20%)
Baz1b	NP_035844.2	WAC_Acf1_DNA_bd	21..120	CDD:287503
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..212		19/69 (28%)
		C motif	207..213		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..333		8/30 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..433		18/79 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..472		6/23 (26%)
		DDT	605..669	CDD:214726	11/78 (14%)
		WHIM1	725..770	CDD:292246	11/57 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	789..813		9/23 (39%)
		WHIM2	900..928	CDD:292247	1/27 (4%)
		WHIM3	991..1029	CDD:292248	11/46 (24%)
		PHD_BAZ1B	1186..1231	CDD:277098	8/47 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1231..1324		28/139 (20%)
		Bromo_WSTF_like	1340..1436	CDD:99937	14/94 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1451..1479
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900