DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dikar and athp-2

DIOPT Version :9

Sequence 1:	NP_001261480.1	Gene:	dikar / 38747	FlyBaseID:	FBgn0261934	Length:	3261	Species:	Drosophila melanogaster
Sequence 2:	NP_494767.2	Gene:	athp-2 / 173769	WormBaseID:	WBGene00019217	Length:	1412	Species:	Caenorhabditis elegans

Alignment Length:	461	Identity:	102/461 - (22%)
Similarity:	172/461 - (37%)	Gaps:	97/461 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   549 SLSPEDKENFCRQLQLLDTNSAAIAVATSIADLSLPSPVAHESETEQDEQVD----------QPA 603
            |::.|:.|:|...::|      |||....|..:.|....|......:||..:          |.|
Worm  1010 SVNLEESEHFSDSMKL------AIAFYMIIKSIHLKFIKAPYISPNKDEHGNLKPSELFIRWQRA 1068

  Fly   604 VVEAQPPALTSAMAPAANVKLPGRQTNNSLSSLTGNIFIPS--GSAQQQQQQSQEPPSSSSSSQS 666
            ::|.                    :::::||     :||.:  ||.:..:.:.|
Worm  1069 LLEC--------------------ESHSALS-----LFISTFEGSIKWDKSRLQ----------- 1097

  Fly   667 GTTTTASTVRSKKQKA-----VLNSSGSSSTSKMADKADRNLSKTETTGKSKKSAAGSSASSSSS 726
                  ...||.::||     ||.|...:.......|.|.|.........:...|......:.:.
Worm  1098 ------GKCRSCRRKAAAHDLVLCSECDNCYHLKCAKLDVNSDAPADWMCTSCRAQQRKVENEAK 1156

  Fly   727 KAERISGAYSDKSGDDHVNSSNRSTTNNNSSLNNNNNHKHAPHHSHNNNNNSHSTTTSATTTATT 791
            :..|.....::.|..:.|...|.|.::|.|.:        ||..:....:.|..||:....|..|
Worm  1157 RMARDDDQLAESSSQEDVAIGNISISDNFSEI--------APKTAEPAESCSTPTTSKEPPTIRT 1213

  Fly   792 TTSQG---YHYNSNLNHNQNHQNSHSHHTHHHHHHHHHTTN------NHSNKH-KTKSHHSLAHN 846
            .:.:.   .|| |:::...:.:|..|:.:...........|      :..|:: .|....|...|
Worm  1214 ASGRAVKRVHY-SDIHEGLSLKNRKSNGSMPVTPSERPVRNVSVRIFDVENENVLTDEDDSDGEN 1277

  Fly   847 NNNNNSPTTNPTSTSLLHPVTTNNNSTYNSSNHANILSFTETEEVLQIGMHKVLVYVKNHRDAWP 911
            .....:||:..:.||   ..|||:.|.....|....::..||          :|........:||
Worm  1278 TRKRKTPTSKKSVTS---TPTTNDISRVIIPNIKEKMTLIET----------LLKEAMRQECSWP 1329

  Fly   912 FVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEM 976
            |:.||:....|.||.:|:|||:|..|.:|:....|:|..|.||||:||::||..||...||..::
Worm  1330 FLQPVDSKEVPDYYDVIKRPMNLRTMMNKIKQRIYNKPIEVRNDFQLILSNCETYNEPENEIYKL 1394

  Fly   977 VNNLQD 982
            ...|.|
Worm  1395 SRELHD 1400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246
dikar	NP_001261480.1	Bromo_gcn5_like	892..991	CDD:99941	33/91 (36%)
athp-2	NP_494767.2	WAC_Acf1_DNA_bd	23..123	CDD:402251
		DDT	457..524	CDD:214726
		WHIM1	629..671	CDD:406127
		WSD	795..897	CDD:406128
		PHD	1100..1144	CDD:214584	10/43 (23%)
		BROMO	1306..1409	CDD:197636	36/105 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900