DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dikar and Brd2

DIOPT Version :9

Sequence 1:	NP_001261480.1	Gene:	dikar / 38747	FlyBaseID:	FBgn0261934	Length:	3261	Species:	Drosophila melanogaster
Sequence 2:	NP_001191902.1	Gene:	Brd2 / 14312	MGIID:	99495	Length:	798	Species:	Mus musculus

Alignment Length:	961	Identity:	199/961 - (20%)
Similarity:	324/961 - (33%)	Gaps:	334/961 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   896 MHKVLV-YVKNHRDAWPFVDPVE--EDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFR 957
            :|||:: .:..|:.||||..||:  :...|.|:.||::|||:..::.:|::..|...||...||.
Mouse    81 LHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFN 145

  Fly   958 LIVNNCRLYNGHNNEYTEMVNNLQDAF-EKATKKYFDNLSDDEDDDPNLSYPAADSKMNVFREKY 1021
            .:..||.:||...::...|...|:..| :|..                 |.|..:.::.|...|.
Mouse   146 TMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVA-----------------SMPQEEQELVVTIPKN 193

  Fly  1022 FSKK-----AKEETEKDAPGRPAVSSAEEDL-----SEI----------------------EAEA 1054
            ..||     |.:.:...|...|||||.....     .||                      .|..
Mouse   194 SHKKGAKLAALQGSITSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGP 258

  Fly  1055 PQKAQKRKRKEKDKRRKKKTKSKADVETDDEDMEAEREPTP--------PPPPPTSKKSKTSKTG 1111
            |..|.......:...:||..|.|||..|          |||        |..||.|.:.|.::..
Mouse   259 PLLAVSAAPPAQPLAKKKGVKRKADTTT----------PTPTAILAPGSPASPPGSLEPKAARLP 313

  Fly  1112 KEKEKD----KEKEKDKDKEKDKETSSFKRGRKTKSDKSASKSSKKTKKGAKKSSADSDPESDPS 1172
            ..:.:.    |...||....:.:..|| |:|:.::..|..:...|:..  :||.:|.:.|...|.
Mouse   314 PMRRESGRPIKPPRKDLPDSQQQHQSS-KKGKLSEQLKHCNGILKELL--SKKHAAYAWPFYKPV 375

  Fly  1173 DSRE--SEDYSDDDHISLAKTKSLVKPTARTIAAQKKKSVPAESKVKMP---TPVKRQVKGKGKG 1232
            |:..  ..||.|                                .:|.|   :.|||:::.:..
Mouse   376 DASALGLHDYHD--------------------------------IIKHPMDLSTVKRKMENRDY- 407

  Fly  1233 GRKAKDDSLDSDQSDVNVKKQLPPT-AAAALAESAAELEEDPDDPPPDEDEDEDSSRSRSMSPFK 1296
             |.|::.:.|......|..|..||. ...|:|....::.|......|||..:.        .|..
Mouse   408 -RDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEP--------GPLP 463

  Fly  1297 VDLHKKYSKSALNDDLSELLTTVKKVPTAETTKLSARHQDEADEERSSRESDGDFKSLSNSRGSS 1361
            |       .:||...|::                                        |:|..||
Mouse   464 V-------STALPPGLTK----------------------------------------SSSESSS 481

  Fly  1362 EERPPVAKKGKKAESSKKEKEKKGRDKDRDRDKEKDKDKSRSAKDKKSKDESPVLVAAAEAAAVV 1426
            ||        ..:|||.:|:|::..|:|.:..:..|.::.|:.:          |....|....|
Mouse   482 EE--------SSSESSSEEEEEEEEDEDEEESESSDSEEERAHR----------LAELQEQLRAV 528

  Fly  1427 QAELDMLLPFMDKYDVIKYRRSRAAFSGSSASNSLAPSEDSKSAITKSNRENRKASAKREKSPDA 1491
            ..:|..|                                 |:..|:|..|:..|...|:::.
Mouse   529 HEQLAAL---------------------------------SQGPISKPKRKREKKEKKKKRK--- 557

  Fly  1492 VENKRGRKSKDQKRSKESDKAEKSDKASKADTEKHSEKSKKKEEPPKVVEKAQREKSPAPVSALE 1556
            .|..|||...|:           .||..:|......:|||               |:....|...
Mouse   558 AEKHRGRIGIDE-----------DDKGPRAPRPPQPKKSK---------------KAGGGGSNAT 596

  Fly  1557 TIKEPPAPTPIATSASGKVKEGPAKKEPKKRPDKQMPPPPKPADKSSEKGSGKKSSS-------- 1613
            |:..|...|      ||    |.:.|.|||  .::..||..|....||:....:..|
Mouse   597 TLSHPGFGT------SG----GSSNKLPKK--SQKTAPPVLPTGYDSEEEEESRPMSYDEKRQLS 649

  Fly  1614 ----KKAAQKAG---------QPQTNNNTNLEALDVETE----QTLKDINRWLEHTPRFTEFSSA 1661
                |...:|.|         :|.. .::|.|.::::.|    .||:::.|::        .|..
Mouse   650 LDINKLPGEKLGRVVHIIQAREPSL-RDSNPEEIEIDFETLKPSTLRELERYV--------LSCL 705

  Fly  1662 SNSPSR-YNLLDDFDSGIGSKLDAADFRRPVA-----LAAPKAELVPTKLAEA---LNELVSEPK 1717
            ...|.: |.:                 |:||.     ||..|...:..:|.:.   ||.....||
Mouse   706 RKKPRKPYTI-----------------RKPVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPK 753

  Fly  1718 EAVSKSESESVAPTPSSVSSSCGTPPHSMHSGNSIGSTSATAASSSNCSNN 1768
            :|..|:||.:.....|.:|:|         |.:|..|:|::::|||:.|::
Mouse   754 KASEKTESSAQQVAVSRLSAS---------SSSSDSSSSSSSSSSSDTSDS 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246
dikar	NP_001261480.1	Bromo_gcn5_like	892..991	CDD:99941	31/98 (32%)
Brd2	NP_001191902.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..72
		Bromo_Brdt_I_like	73..179	CDD:99929	31/114 (27%)
		PHA03247	<215..332	CDD:223021	28/126 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..348		22/91 (24%)
		Bromo_Brdt_II_like	348..449	CDD:99930	26/136 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..645		62/337 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	553..557		1/3 (33%)
		BET	639..701	CDD:407211	11/62 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..798		20/69 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900