|
Fly 160 NSGYWYFYGTRLYREDKATGGSASSSSGS-GSGGAGASTG---------GASNS----------- 203
|||:... ::|:.|.|...:|| |:.|.|...| |||:|
Human 192 NSGHSLI--------NQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSP 248
Fly 204 ------------------KGI-GSNGTVWQVICFTEEDWQNLAAKFKTSTNAKERELFNILDDNF 249
.|| |:.....|. |::...|.:.|.......|.::.:. |.
Human 249 QMTGHAGLNTAQAGGMAKMGITGNTSPFGQP--FSQAGGQPMGATGVNPQLASKQSMV-----NS 306
Fly 250 LPKLPQLFRERERLRRRKLLQVRNSSRIRN---------IAELKARQEEER-------------- 291
||..| ..::...:..|.|.|:::. ||.......|:|
Human 307 LPTFP------TDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAH 365
Fly 292 --QRREREN-------LYQDRQNAHWLAPPQQQQQQQQQQQQQQQQSQQ---------------- 331
||||:.| |...|...:.|......|..:..|......|:|
Human 366 KCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVC 430
Fly 332 -----RTRRRSQST---STASGISTYASSLRRTTTTNSSEFLCHRETFCLSPENDEDDDDDDEA- 387
.:.:|:|.| |.||||.....|: .|...|::. ||..|..|......|
Human 431 LPLKNASDKRNQQTILGSPASGIQNTIGSV-GTGQQNATS---------LSNPNPIDPSSMQRAY 485
Fly 388 -------LDAEQQSDQPEQQRQQEEQPPEEEQR---------------------QEPEELLAVSA 424
::..|...||:...||..||...:|. |:|..|::.||
Human 486 AALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESA 550
Fly 425 -----------TDDDFRS------PEAPKSQTPAELKSKSSHHHH-------HHHHK-------- 457
.:|...| ...|.:..|:....:...|.| |..||
Human 551 LPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPT 615
Fly 458 ------------------KKKSSKKQKKRHHRDKGRERDREHHH-------------HHRRR--- 488
||......:..:.|| |::| ..:||
Human 616 PDPAALKDRRMENLVAYAKKVEGDMYESANSRD-------EYYHLLAEKIYKIQKELEEKRRSRL 673
Fly 489 HKHA------------------SEADEGEDDNN------NHNSNSNSNSNTNSISSNNSVQ---- 525
||.. .:|......|. |....|...::.|.:|..| ||
Human 674 HKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGN-VQLPQA 737
Fly 526 PKRRRSGQQQQHHQQAET--TEPSTSLSPE-----------DKENFCRQL----QLLDTN----- 568
|...|:.....|..|..: :.|..::||. ...|...|. |.|..|
Human 738 PMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSS 802
Fly 569 SAAIAVAT------------SIADLSLPSPVAHESETEQDEQVDQPAVVEA-----QPPALTSAM 616
|.|::|.. .:...:||:|: .....|..|:..|.|.:: .|||.|:|.
Human 803 SGAMSVGMGQPPAQTGVSQGQVPGAALPNPL--NMLGPQASQLPCPPVTQSPLHPTPPPASTAAG 865
Fly 617 APA-ANVKLPG---------RQTNNSLSSLTGNIFIPSGSAQQQQQQSQEPPSSSSSSQSGTTTT 671
.|: .:...|| .|.:..:|| :|....|:..:.....|:|..|:..:::|:..|..
Human 866 MPSLQHTTPPGMTPPQPAAPTQPSTPVSS-SGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQ 929
Fly 672 ASTVRSKKQKAVLNSSGSSSTSKMADKADRNLSKTETTGKSKKSAAGSSASSSSSKAERISGAYS 736
..|.......|...||....|...|......||:...:..::.....|.||:.:: |
Human 930 PQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETN---------S 985
Fly 737 DKSGDDHVNSSNRSTTNNNSSLNNNNNHKHAPHHSHNNNNNSHSTTTSATTTATTTTSQGYHYNS 801
.:.|.|......::.|....:..:....|..|.......:...::.....|......|:....:.
Human 986 QQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDE 1050
Fly 802 NLNHNQNHQNSHSHHTHHHHHHHHHTTNNHSNKHKTKSHHSLAHNNNNNNSPTTNPTSTSLLHPV 866
.....|.:.|.....:.|...:.|.:.:.....:..|
Human 1051 ---------------------------KKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKP- 1087
Fly 867 TTNNNSTYNSSNHANILSFTETEEVLQIGMHKVLVYVKNHRDAWPFVDPVEEDI--APRYYSIIR 929
||:.|..|..:....:...::.||..||:..: .|.|:.|::
Human 1088 ----------------------EELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVK 1130
Fly 930 RPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMVNNLQDAFEKATKKYFDN 994
.||||..::.|||:|:|.:..::.:|..|:.||..|||...:...:..:.|.:.||
Human 1131 NPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFE--------- 1186
Fly 995 LSDDEDDDP---NLSYPAADSKMNVFREKYFSKKAKEETEKDAPGRPAVSSAEEDLSEIEAEAPQ 1056
::.|| :|.|... |:..||.: .:....:.|..|..:|..
Human 1187 ----QEIDPVMQSLGYCCG-------RKYEFSPQ-------------TLCCYGKQLCTIPRDAAY 1227
Fly 1057 KAQKRKRKEKDKRRKKKTKSKADVETDDEDMEAEREPTPPPPPPTSKKSKTSKTGKEKEKDKEKE 1121
.:.:.:....: |...|...|::....:|:.| :|:.:..:.||.|...
Human 1228 YSYQNRYHFCE---------KCFTEIQGENVTLGDDPSQP---------QTTISKDQFEKKKNDT 1274
Fly 1122 KDKDKEKD-KE-----------------TSSF-------KRGRKTKSDKSASKSSKKTKKGAKKS 1161
.|.:...| || .|.| |.||..|.:|.::|..:.|:.|
Human 1275 LDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLG---- 1335
Fly 1162 SADSDPESDPSDSRESEDYSDDDHISLAKTKSLVKPTARTIAAQKKKSVPAESKVKMPTPVKRQV 1226
:|:.....|.| ::::.|...:|.:........
Human 1336 ----------------------NHLEDRVNKFL-----------RRQNHPEAGEVFVRVVASSDK 1367
Fly 1227 KGKGKGGRKAKDDSLDSDQSDVNVKKQLPPTAAAALAESAAE-----------LEEDPDDPPPDE 1280
..:.|.|.|:: .:||.: :.:..|....|..|....: .|...|.|||
Human 1368 TVEVKPGMKSR--FVDSGE----MSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPP-- 1424
Fly 1281 DEDEDSSRSRSMSPFKVDLH----KKYSKSALNDDLSELLTTVKKVPTAETTKLSARHQDEADEE 1341
:..|....:...:| :....:..::.|...|..|||:... |..:.|....|.|
Human 1425 ------NTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYV-TGHIWACPPSEGD-- 1480
Fly 1342 RSSRESDGDFKSLSNSRGSSEERPPVAK--KGKKAESSKKEKEKKGRDKD---------RDRDKE 1395
|..|.. .||..| |.|:.: |..||..||. :|..|:
Human 1481 ------DYIFHC----------HPPDQKIPKPKRLQ----EWYKKMLDKAFAERIIHDYKDIFKQ 1525
Fly 1396 KDKDKSRSAKDKKSKDESPVLVAAAEAAAVVQAELDMLLPFMDKYDVIKYRRSRAAFSGSSASNS 1460
..:|:..|||: ||: |.|....|.
Human 1526 ATEDRLTSAKE---------------------------LPY---------------FEGDFWPNV 1548
Fly 1461 LAPSEDSKSAITKSNRENRKASAKREKSPDAVENKRGRKSKDQKRSKESDKAEKSDKASKADTEK 1525
| |:|...:.:...|. |:|:|..|.|...|.:...:...|:::|....:|:|
Human 1549 L---EESIKELEQEEEER-----KKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSS------ 1599
Fly 1526 HSEKSKKKEEPPKVVEKAQREKSPAPVSALETIKE----------------PPA--PTPIATSAS 1572
.|..:|||...|.| ..:.|....:.:|..|| ||. |.|: .|
Human 1600 ISRANKKKPSMPNV----SNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPL---LS 1657
Fly 1573 GKVKEGPAKKEPKKRPDKQMPPPPKPADKSSEKGSGKKSSSKKAA-----QKAGQPQTNNNTNLE 1632
..:.:|........| ||..|..|.::|...... ...||.:.....|..
Human 1658 CDLMDGRDAFLTLAR------------DKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNEC 1710
Fly 1633 ALDVETEQTLKDINRWLEHTPRFTEFSSASNSPSRYNLLDDFDSGIGSKLDAADFRRPVALAAPK 1697
...||| || ...:.:|:|..|......:...:.|
Human 1711 KHHVET--------RW------------------HCTVCEDYDLCINCYNTKSHAHKMV------ 1743
Fly 1698 AELVPTKLAEALNELVSEPKEAVSKSESESVAPTPS---SVSSSCGTPPHSMHSGNSIGSTSATA 1759
|....|:: |..|:.|.:|.:|..| |:.....:..|:....|
Human 1744 ------KWGLGLDD------EGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRN--------- 1787
Fly 1760 ASSSNCSNNSMPTPLPVAVTPTPTPAPPPLLPIPKPKEPSTTQLILNPPPPPHIKQQLAKEAKRK 1824
:||| ||
Human 1788 ---ANCS-----------------------LP--------------------------------- 1793
Fly 1825 SLKEKQAAQAAQAQQVKAKANVMRTIDRLQPGKAKGNLLQNVVAVKSTEEGGDSHAGVNPVTTKV 1889
..|::| |.:...:..|.|.| |..||..:
Human 1794 -----------SCQKMK------RVVQHTKGCKRKTN-------------------GGCPVCKQ- 1821
Fly 1890 KELKNALITETCEGAPK-----------LSLGTVLKTQDFSLGKSLEEMSGKKDANEDDR--PNE 1941
||...|..|.. |::...|:.|.........::..::.|..:.| |.:
Human 1822 ------LIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQ 1880
Fly 1942 EASPKNSSPPTTPNTEAPKPFEALHELSKRGKSSEPSKSEASQKEKPNLSAWLKAFGGPKVSKKS 2006
......|:||.||..:...|
Human 1881 SLPSPTSAPPGTPTQQPSTP--------------------------------------------- 1900
Fly 2007 EDEEKQQTPVQDLQGDSKVAPPAHSPAGDNFSLPTVMRQRKPSTGSTNSERSSFSQDPDSPRIAI 2071
|||....| .:.:|.:.|||| .|:|.|.:.|:|.||
Human 1901 ------QTPQPPAQ--PQPSPVSMSPAG----FPSVARTQPPTTVST------------------ 1935
Fly 2072 DERYGSYAAGSYTSPIGASPIGASPIMVSPKPNDDMGKPASPYPLNGAIKVGFYQDTTTKSSPDK 2136
|..||.:.|.| .||.|.| .|::
Human 1936 ---------GKPTSQVPAPP-----------------PPAQPPP--AAVE--------------- 1957
Fly 2137 SCSPREMNSPYPQYSQHIYSSASSPNVSTPDMSGTSPYGGGNSYNPSGSEASKTPAYSSTSPLPI 2201
:.|::... .|..||:| ..|: |:..|.|.....||. |..:|:.:
Human 1958 --AARQIERE-AQQQQHLY----RVNI--------------NNSMPPGRTGMGTPG-SQMAPVSL 2000
Fly 2202 YDQYKQPRSQESDYNSSMSPSTPNPHSPYQQPQSSPYTTPQQSQSTHPSPYHNQSPYHQQQHSPY 2266
..||..: .:..:.||.| |.|.| |:|..|||..|.
Human 2001 ----NVPRPNQ--VSGPVMPSMP----------------PGQWQ---------QAPLPQQQPMPG 2034
Fly 2267 HP-PAAQQQQQ---------SSQP--SHSPAAHQQALSPMHSVESP------------------- 2300
.| |....|.| |.|| |.||:|.|..|..:.|..||
Human 2035 LPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAA 2099
Fly 2301 ------ASSAATQP---PTPLAQSPAEQQHSP--YQQPVLSPYQQPQQQVQPPVVPPVQPSAGAQ 2354
|...|.|| |.|..||....|..| :|||.|......|..|..|.|||.|.:.|
Human 2100 FIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMG-- 2162
Fly 2355 ASTALGNNGYAPTHDSYQQLQQQQRSLYNPATLINPLSTAASSTASITKPNNDWSLNRSLLPPSI 2419
|..| |.|..::.||.. || :.||: .|.....|.|.||
Human 2163 --------GLNP--------QGQALNIMNPGH--NP------NMASM-NPQYREMLRRQLL---- 2198
Fly 2420 TNTVNQAAQQQQQQQQQQAGQLQQQPQMQAAQQQLQSTPQQQQQQLQGTP----------QQQQL 2474
|||||||||| ||||||.||:. |.||.
Human 2199 --------QQQQQQQQQQ---------------------QQQQQQQQGSAGMAGGMAGHGQFQQP 2234
Fly 2475 QG------SQQQQQQQQQQQQLQTSQQQQQQVLGHQQQHKPKYPTYAQYQSTNAAANAAAAADAV 2533
|| :.||||:.||...||.|...|.. ||.............||:.
Human 2235 QGPGGYPPAMQQQQRMQQHLPLQGSSMGQMA---------------AQMGQLGQMGQPGLGADST 2284
Fly 2534 DN---------LQQQQ--QKIAPPTYGSDMATFMQHQMQQPPKTDTLINPLKRPGEEIGMDYSGN 2587
.| ||||| |:|..|...:.|:. .||.:...|:...| ||::|
Human 2285 PNIQQALQQRILQQQQMKQQIGSPGQPNPMSP-QQHMLSGQPQASHL------PGQQI------- 2335
Fly 2588 AANKMQKREETPAQQQQQQQQQQPTQNQTQSLLNKQQQMFNSFLGTMAFGKPIGNIAPDKAFEMY 2652
|..:..:..:||..|..:.|.||..:.....:..|....:....| |.|...:|...|..:
Human 2336 -ATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQT---GSPHPGLAVTMASSI- 2395
Fly 2653 NRAAAMGFPKDFAKDNSCQLQQQQQQQQSPQVTTNKQQA 2691
:...|...:|....||:.|..:.|
Human 2396 ---------------DQGHLGNPEQSAMLPQLNTPSRSA 2419
| 
