DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dikar and Crebbp

DIOPT Version :9

Sequence 1:NP_001261480.1 Gene:dikar / 38747 FlyBaseID:FBgn0261934 Length:3261 Species:Drosophila melanogaster
Sequence 2:XP_006521814.1 Gene:Crebbp / 12914 MGIID:1098280 Length:2451 Species:Mus musculus


Alignment Length:3084 Identity:560/3084 - (18%)
Similarity:831/3084 - (26%) Gaps:1284/3084 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   190 SGGAGASTGGASNSKGIGSNGTV---WQVICFTEEDWQNLAAKFKTSTNAKERELFNILDDNFLP 251
            :|.||.:|..|.....:|..||.   .|.  |::...|.:.|.......|.::.:.     |.||
Mouse   250 AGHAGLNTAQAGGMTKMGMTGTTSPFGQP--FSQTGGQQMGATGVNPQLASKQSMV-----NSLP 307

  Fly   252 KLPQLFRERERLRRRKLLQVRNSSRIRN---------IAELKARQEEER---------------- 291
            ..|      ..::...:..|.|.|:::.         ||.......|:|                
Mouse   308 AFP------TDIKNTSVTTVPNMSQLQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKC 366

  Fly   292 QRREREN-------LYQDRQNAHWLAPPQQQQQQQQQQQQQQQQSQQ------------------ 331
            ||||:.|       |...|...:.|......|..:..|......|:|                  
Mouse   367 QRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLP 431

  Fly   332 ---RTRRRSQST---STASGISTYASSLRRTTTTNSSEFLCHRETFCLSPENDEDDDDDDEA--- 387
               .:.:|:|.|   |.||||.....|:.......:|          ||..|..|......|   
Mouse   432 LKNASDKRNQQTILGSPASGIQNTIGSVGAGQQNATS----------LSNPNPIDPSSMQRAYAA 486

  Fly   388 -----LDAEQQSDQPEQQRQQEEQPPEEEQR---------------------QEPEELLAVSA-- 424
                 ::..|...||:...||..|||..:|.                     |:|..|::.||  
Mouse   487 LGLPYMNQPQTQLQPQVPGQQPAQPPAHQQMRTLNALGNNPMSIPAGGITTDQQPPNLISESALP 551

  Fly   425 ---------TDDDFRS------PEAPKSQTPAELKSKSSHHHH-------HHHHK---------- 457
                     .:|...|      ...|.:..|:....:...|.|       |..||          
Mouse   552 TSLGATNPLMNDGSNSGNIGSLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPD 616

  Fly   458 ----------------KKKSSKKQKKRHHRDKGRERDREHHH-------------HHRRR---HK 490
                            ||......:..:.||       |::|             ..:||   ||
Mouse   617 PAALKDRRMENLVAYAKKVEGDMYESANSRD-------EYYHLLAEKIYKIQKELEEKRRSRLHK 674

  Fly   491 HA------------------SEADEGEDDNN------NHNSNSNSNSNTNSISSNNSVQ----PK 527
            ..                  ..|......|.      |....|...::.|.:|..| ||    |.
Mouse   675 QGILGNQPALPASGAQPPVIPPAQSVRPPNGPLPLPVNRMQVSQGMNSFNPMSLGN-VQLPQAPM 738

  Fly   528 RRRSGQQQQHHQQAET--TEPSTSLSPE---------------------DKENFCRQLQL----- 564
            ..|:.....|..|..:  :.|..::||.                     .:..|..|.|.     
Mouse   739 GPRAASPMNHSVQMNSMASVPGMAISPSRMPQPPNMMGTHANNIMAQAPTQNQFLPQNQFPSSSG 803

  Fly   565 -LDTNSAAIAVATSIADLS--------LPSPVAHESETEQDEQVDQPAVVEA-----QPPALTSA 615
             :..||..:....:.|.:|        ||:|:  .....|..|:..|.|.::     .|||.|:|
Mouse   804 AMSVNSVGMGQPAAQAGVSQGQVPGAALPNPL--NMLAPQASQLPCPPVTQSPLHPTPPPASTAA 866

  Fly   616 --------MAPAANVKLPGRQTNNSLSSLTGNIFIPSGSAQQQQQQSQEPPSSSSSSQSGTTTTA 672
                    .||......|...|..|....:|....|:..:.....|:|..|:..:::|:..|...
Mouse   867 GMPSLQHPTAPGMTPPQPAAPTQPSTPVSSGQTPTPTPGSVPSAAQTQSTPTVQAAAQAQVTPQP 931

  Fly   673 STVRSKKQKAVLNSSGSSSTSKMADKADRNLSKTETTGKSKKSAAGSSASSSSSKAERISGAYSD 737
            .|.......|...||....|..........||:...:..::.....|..|:.:|         |.
Mouse   932 QTPVQPPSVATPQSSQQQPTPVHTQPPGTPLSQAAASIDNRVPTPSSVTSAETS---------SQ 987

  Fly   738 KSGDDHVNSSNRSTTNNNSSLNNNNNHKHAPHHSHNNNNNSHSTTTSATTTATTTTSQGYHYNSN 802
            :.|.|......::....:.:.......|..|.......:...|:.....|..|...|:....   
Mouse   988 QPGPDVPMLEMKTEVQTDDAEPEPTESKGEPRSEMMEEDLQGSSQVKEETDTTEQKSEPMEV--- 1049

  Fly   803 LNHNQNHQNSHSHHTHHHHHHHHHTTNNHSNKHKTKSHHSLAHNNNNNNSPTTNPTSTSLLHPVT 867
                                        ...|.:.|........|::|:                
Mouse  1050 ----------------------------EEKKPEVKVEAKEEEENSSND---------------- 1070

  Fly   868 TNNNSTYNSSNHANILSFTETEEVLQIGMHKVLVYVKNHRDAWPFVDPVEEDI--APRYYSIIRR 930
            |.:.||..|.....|.   :.||:.|..|..:....:...::.||..||:..:  .|.|:.|::.
Mouse  1071 TASQSTSPSQPRKKIF---KPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKN 1132

  Fly   931 PMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMVNNLQDAFEKATKK----- 990
            ||||..::.|||:|:|.:..::.:|..|:.||..|||...:...:..:.|.:.||:....     
Mouse  1133 PMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 1197

  Fly   991 -----------------YFDNLSDDEDDDPNLSYPAADSKMNVFREKY-FSKKAKEETEKDAPGR 1037
                             |...|.....|....||..:..|..:..::| |.:|.           
Mouse  1198 GYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNSSPKYGLLADRYHFCEKC----------- 1251

  Fly  1038 PAVSSAEEDLSEIEAEAPQKAQKRKRKEKDKRRKKKTKSKADVETDDEDMEAEREPTPPPPPPTS 1102
                     .:||:.|                         :|...|:         |..|..|.
Mouse  1252 ---------FTEIQGE-------------------------NVTLGDD---------PSQPQTTI 1273

  Fly  1103 KKSKTSKTGKEKEKDKEKEKDKDKEKD-KE-----------------TSSF-------KRGRKTK 1142
            .|.       :.||.|....|.:...| ||                 .|.|       |.||..|
Mouse  1274 SKD-------QFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRK 1331

  Fly  1143 SDKSASKSSKKTKKGAKKSSADSDPESDPSDSRESEDYSDDDHISLAKTKSLVKPTARTIAAQKK 1207
            .:|.::|..:.|:.|                          :|:.....|.|           ::
Mouse  1332 ENKFSAKRLQTTRLG--------------------------NHLEDRVNKFL-----------RR 1359

  Fly  1208 KSVPAESKVKMPTPVKRQVKGKGKGGRKAKDDSLDSDQSDVNVKKQLPPTAAAALAESAAE---- 1268
            ::.|...:|.:..........:.|.|.|::  .:||.:    :.:..|....|..|....:    
Mouse  1360 QNHPEAGEVFVRVVASSDKTVEVKPGMKSR--FVDSGE----MSESFPYRTKALFAFEEIDGVDV 1418

  Fly  1269 -------LEEDPDDPPPDEDEDEDSSRSRSMSPFKVDLH----KKYSKSALNDDLSELLTTVKKV 1322
                   .|...|.|||        :..|....:...:|    :....:..::.|...|..|||:
Mouse  1419 CFFGMHVQEYGSDCPPP--------NTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKL 1475

  Fly  1323 PTAETTKLSARHQDEADEERSSRESDGDFKSLSNSRGSSEERPPVAK--KGKKAESSKKEKEKKG 1385
            ... |..:.|....|.|        |..|..          .||..|  |.|:.:    |..||.
Mouse  1476 GYV-TGHIWACPPSEGD--------DYIFHC----------HPPDQKIPKPKRLQ----EWYKKM 1517

  Fly  1386 RDKD---------RDRDKEKDKDKSRSAKDKKSKDESPVLVAAAEAAAVVQAELDMLLPFMDKYD 1441
            .||.         :|..|:.::|:..|||:                           ||:     
Mouse  1518 LDKAFAERIINDYKDIFKQANEDRLTSAKE---------------------------LPY----- 1550

  Fly  1442 VIKYRRSRAAFSGSSASNSLAPSEDSKSAITKSNRENRKASAKREKSPDAVENKRGRKSKDQKRS 1506
                      |.|....|.|   |:|...:.:...|.     |:|:|..|.|...|.:...:...
Mouse  1551 ----------FEGDFWPNVL---EESIKELEQEEEER-----KKEESTAASETPEGSQGDSKNAK 1597

  Fly  1507 KESDKAEKSDKASKADTEKHSEKSKKKEEPPKVVEKAQREKSPAPVSALETIKE----------- 1560
            |:::|....:|:|      .|..:|||...|.|    ..:.|....:.:|..||           
Mouse  1598 KKNNKKTNKNKSS------ISRANKKKPSMPNV----SNDLSQKLYATMEKHKEVFFVIHLHAGP 1652

  Fly  1561 -----PPA--PTPIATSASGKVKEGPAKKEPKKRPDKQMPPPPKPADKSSEKGSGKKSSSKKAA- 1617
                 ||.  |.|:   .|..:.:|........|            ||..|..|.::|...... 
Mouse  1653 VISTQPPIVDPDPL---LSCDLMDGRDAFLTLAR------------DKHWEFSSLRRSKWSTLCM 1702

  Fly  1618 ----QKAGQPQTNNNTNLEALDVETEQTLKDINRWLEHTPRFTEFSSASNSPSRYNLLDDFDSGI 1678
                ...||.:.....|.....|||        ||                  ...:.:|:|..|
Mouse  1703 LVELHTQGQDRFVYTCNECKHHVET--------RW------------------HCTVCEDYDLCI 1741

  Fly  1679 GSKLDAADFRRPVALAAPKAELVPTKLAEALNELVSEPKEAVSKSESESVAPTPS---SVSSSCG 1740
            ......:...:.|            |....|::      |..|:.|.:|.:|..|   |:.....
Mouse  1742 NCYNTKSHTHKMV------------KWGLGLDD------EGSSQGEPQSKSPQESRRLSIQRCIQ 1788

  Fly  1741 TPPHSMHSGNSIGSTSATAASSSNCSNNSMPTPLPVAVTPTPTPAPPPLLPIPKPKEPSTTQLIL 1805
            :..|:....|            :|||                       ||              
Mouse  1789 SLVHACQCRN------------ANCS-----------------------LP-------------- 1804

  Fly  1806 NPPPPPHIKQQLAKEAKRKSLKEKQAAQAAQAQQVKAKANVMRTIDRLQPGKAKGNLLQNVVAVK 1870
                                          ..|::|      |.:...:..|.|.|         
Mouse  1805 ------------------------------SCQKMK------RVVQHTKGCKRKTN--------- 1824

  Fly  1871 STEEGGDSHAGVNPVTTKVKEL---------KNALITETCEGAPKLSLGTVLKTQDFSLGKSLEE 1926
                      |..||..::..|         :|......|     |::...|:.|.........:
Mouse  1825 ----------GGCPVCKQLIALCCYHAKHCQENKCPVPFC-----LNIKHKLRQQQIQHRLQQAQ 1874

  Fly  1927 MSGKKDANEDDR--PNEEASPKNSSPPTTPNTEAPKPFEALHELSKRGKSSEPSKSEASQKEKPN 1989
            :..::.|..:.|  |.:......|:||.||..:...|                            
Mouse  1875 LMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTP---------------------------- 1911

  Fly  1990 LSAWLKAFGGPKVSKKSEDEEKQQTPVQDLQGDSKVAPPAHSPAGDNFSLPTVMRQRKPSTGSTN 2054
                                   |||....|  .:.:|...||||    .|.|.|.:.|:..|  
Mouse  1912 -----------------------QTPQPPAQ--PQPSPVNMSPAG----FPNVARTQPPTIVS-- 1945

  Fly  2055 SERSSFSQDPDSPRIAIDERYGSYAAGSYTSPIGASPIGASPIMVSPKPNDDMGKPASPYPLNGA 2119
                                     ||..|:.:.|.|                 .||.|.|  .|
Mouse  1946 -------------------------AGKPTNQVPAPP-----------------PPAQPPP--AA 1966

  Fly  2120 IKVGFYQDTTTKSSPDKSCSPREMNSPYPQYSQHIYSSASSPNVSTPDMSGTSPYGGGNSYNPSG 2184
            ::                 :.|::... .|..||:|.:    |:              |:..|.|
Mouse  1967 VE-----------------AARQIERE-AQQQQHLYRA----NI--------------NNGMPPG 1995

  Fly  2185 SEASKTPAYSSTSPLPIYDQYKQPRSQESDYNSSMSPSTPNPHSPYQQPQSSPYTTPQQSQSTHP 2249
            .....||                        .|.|:|...|...|.|  .|.|.      .|:.|
Mouse  1996 RAGMGTP------------------------GSQMTPVGLNVPRPNQ--VSGPV------MSSMP 2028

  Fly  2250 SPYHNQSPYHQQQHSPYHP-PAAQQQQQSS---------QP--SHSPAAHQQALSPMHSVESP-- 2300
            .....|:|..|||..|..| |....|.|::         ||  |.||:|.|..|..:.|..||  
Mouse  2029 PGQWQQAPIPQQQPMPGMPRPVMSMQAQAAVAGPRMPNVQPPRSISPSALQDLLRTLKSPSSPQQ 2093

  Fly  2301 -----------------------ASSAATQP---PTPLAQSPAEQQHSP--YQQPVLSPYQQPQQ 2337
                                   |...|.||   |.|..||....|..|  :|||.|......|.
Mouse  2094 QQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQA 2158

  Fly  2338 QVQPPVVPPVQPSAGAQASTALGNNGYAPTHDSYQQLQQQQRSLYNPATLINPLSTAASSTASIT 2402
            .|..|.|||.||:.|.                                  :||...|    .:|.
Mouse  2159 GVPRPGVPPPQPAMGG----------------------------------LNPQGQA----LNIM 2185

  Fly  2403 KPNNDWSLNRSLLPPSITNTVNQAAQQQQQQQQQQAGQLQQQPQMQAAQQQLQSTPQQQQQQLQG 2467
            .|.::         |::||                                  ..||.::.    
Mouse  2186 NPGHN---------PNMTN----------------------------------MNPQYREM---- 2203

  Fly  2468 TPQQQQLQGSQQQQQQQQQQQQLQTSQQQQQQVLGHQQQHKPKYPTYAQYQSTNAAANAAAAADA 2532
             .::|.||..||||||||||||.|.|......:.||.|..:|:.|                    
Mouse  2204 -VRRQLLQHQQQQQQQQQQQQQQQNSASLAGGMAGHSQFQQPQGP-------------------- 2247

  Fly  2533 VDNLQQQQQKIAPPTYGSDMATFMQHQMQQPPKTDTLINPLKRPGEEIGMDYSGNAANKMQKREE 2597
                                                                 |..|        
Mouse  2248 -----------------------------------------------------GGYA-------- 2251

  Fly  2598 TPAQQQQQQQQQQPTQNQTQSLLNKQQQMFNSFLGTMAFGKPIGNIAPDKAFEMYNRAAAMGFPK 2662
             ||.|||:.||..|.|              .|.:|.|                    ||.||   
Mouse  2252 -PAMQQQRMQQHLPIQ--------------GSSMGQM--------------------AAPMG--- 2278

  Fly  2663 DFAKDNSCQLQQQQQQQQSPQVTTNKQQANQQTQQQPQQQSQQ----SQPHLTQLQTALSQNYQQ 2723
                    ||.|..|.......|.|.|||.||...|.||..||    .||:      .:|.....
Mouse  2279 --------QLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPN------PMSPQQHM 2329

  Fly  2724 QQQQTQAQKLPQQQ-------QQQPPQQLNYQQQQAQLNHNYTAQQQATAVPDKPPAAQSTVAAA 2781
            ...|.||..||.||       |.:.|..:...:.|:|..|                         
Mouse  2330 LSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPH------------------------- 2369

  Fly  2782 VSESSSNMMNLPSTAHQHHLS-QTHHLAAYNKPTPPPPQTYSNPLMQSMLGYAGNYFDKTMPPAA 2845
             |..|..:...||   .||:| ||      ..|.|....|.::.:.|   |:.||.....|.|..
Mouse  2370 -SSPSPRIQPQPS---PHHVSPQT------GSPHPGLAVTMASSMDQ---GHLGNPEQSAMLPQL 2421

  Fly  2846 HM--YSASSSAASAYGNPAQQLPGNYVPG 2872
            :.  .||.||..|..|:........:|.|
Mouse  2422 NTPNRSALSSELSLVGDTTGDTLEKFVEG 2450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dikarNP_001261480.1 WHIM1 100..148 CDD:292246
Bromo_gcn5_like 892..991 CDD:99941 28/122 (23%)
CrebbpXP_006521814.1 zf-TAZ 362..429 CDD:366931 12/66 (18%)
KIX 586..666 CDD:366953 11/86 (13%)
PHA03247 <687..1037 CDD:223021 63/361 (17%)
COG5076 942..>1194 CDD:227408 56/310 (18%)
Bromo_cbp_like 1088..1195 CDD:99927 30/106 (28%)
RING_CBP-p300 1207..1289 CDD:276805 22/142 (15%)
PHD_CBP_p300 1291..1322 CDD:277032 5/30 (17%)
HAT_KAT11 1353..>1564 CDD:369758 53/303 (17%)
ZZ_CBP 1716..1756 CDD:239077 10/77 (13%)
ZnF_TAZ 1777..1855 CDD:214717 21/186 (11%)
Med15 1971..>2422 CDD:312941 164/758 (22%)
Creb_binding 2045..2125 CDD:370251 18/79 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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