DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dikar and BAZ2A

DIOPT Version :9

Sequence 1:	NP_001261480.1	Gene:	dikar / 38747	FlyBaseID:	FBgn0261934	Length:	3261	Species:	Drosophila melanogaster
Sequence 2:	XP_011536103.1	Gene:	BAZ2A / 11176	HGNCID:	962	Length:	1912	Species:	Homo sapiens

Alignment Length:	1557	Identity:	285/1557 - (18%)
Similarity:	486/1557 - (31%)	Gaps:	556/1557 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1915 TQDFSLGKSLEEMSGKKDANE--DDRPNEEASPKNSSPP---TTPNT-----EAPKPFEALHELS 1969
            :|:|....:...|....|:.|  |..|::......:.||   |:|.|     .:.:.|....|:
Human   146 SQEFWANGTQSPMGLNFDSQELYDSFPDQNFEVMPNGPPSFFTSPQTSPMLGSSIQTFAPSQEV- 209

  Fly  1970 KRGKSSEPSKSEASQKEKPNLSAWLKAFGGPKVSKKSEDEEKQQTPVQDLQGDSKVAPPAHSPAG 2034
              |....|  .||::||..:    :.|..|..:....|.||:|               |.....|
Human   210 --GSGIHP--DEAAEKEMTS----VVAENGTGLVGSLELEEEQ---------------PELKMCG 251

  Fly  2035 DNFSLPTVMRQRKPSTGSTNSERSSFSQDP-----DSPRIAIDERYGSYAAGSYTSPIGASPIGA 2094
            .|.|:|:|        .|.:.|.|....||     |.|....|:                  :..
Human   252 YNGSVPSV--------ESLHQEVSVLVPDPTVSCLDDPSHLPDQ------------------LED 290

  Fly  2095 SPIMVSPKPNDDMGKP---ASPYPLNGAIKVGFY--QDTTTKSSPDKSCSPREMNSPY------- 2147
            :||:     ::|..:|   .:|.|::|    |.|  .||....:.||  .|.| :||.
Human   291 TPIL-----SEDSLEPFNSLAPEPVSG----GLYGIDDTELMGAEDK--LPLE-DSPVISALDCP 343

  Fly  2148 --------------PQYSQHIYSSASSPNVSTPDMSGTSPYGGGNSYNPSGSEASKTPAYSSTSP 2198
                          .|.|..|::|.:||.|....:...:.:...|     ||:|
Human   344 SLNNATAFSLLADDSQTSTSIFASPTSPPVLGESVLQDNSFDLNN-----GSDA----------- 392

  Fly  2199 LPIYDQYKQPRSQESDYNSSMSPSTPNPHSPYQQPQSSPYTTPQQSQSTHPSPYHNQSPYHQQQH 2263
                 :.::..:|.||:..|::...|:..|..   |..|.|:|..|.:|.|:.....||....:.
Human   393 -----EQEEMETQSSDFPPSLTQPAPDQSSTI---QLHPATSPAVSPTTSPAVSLVVSPAASPEI 449

  Fly  2264 SPYHPPAAQQQQQSSQPSHSPAAHQQALSP-MHSVESPASSA---ATQPPTPLAQSPAEQQHSPY 2324
            ||...|||                ...:|| :.||.||||||   |.....||..|....:.||.
Human   450 SPEVCPAA----------------STVVSPAVFSVVSPASSAVLPAVSLEVPLTASVTSPKASPV 498

  Fly  2325 QQPVLS-PYQQP--------------------------------QQQVQPP--VVPPVQPSAGAQ 2354
            ..|..: |...|                                ::::..|  |..|:|.....:
Human   499 TSPAAAFPTASPANKDVSSFLETTADVEEITGEGLTASGSGDVMRRRIATPEEVRLPLQHGWRRE 563

  Fly  2355 ASTALGNNG-------YAP-----------------------------------------THDSY 2371
            .....|::.       |.|                                         ..|:.
Human   564 VRIKKGSHRWQGETWYYGPCGKRMKQFPEVIKYLSRNVVHSVRREHFSFSPRMPVGDFFEERDTP 628

  Fly  2372 QQLQQQQRSLYNPATLI--------NPLSTAASSTASITKPNN--------------DWSLNRSL 2414
            :.||..|.|.....:.|        .|.:|..:.|..:.|...              :.:.||.|
Human   629 EGLQWVQLSAEEIPSRIQAITGKRGRPRNTEKAKTKEVPKVKRGRGRPPKVKITELLNKTDNRPL 693

  Fly  2415 LPPSITNTVNQ------AAQQQQQQQQQQAGQLQQQPQMQAAQQQLQSTPQQQQQQLQGTPQQQQ 2473
            .......|:|:      |..:::.:|:.|.|:.|...|.||..::.|.|              :.
Human   694 KKLEAQETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARNKRKQET--------------KS 744

  Fly  2474 LQGSQQQQQQQQQQQQLQTSQQQQQQVLGHQQQHKPKYPTYAQYQSTNAAANA---AAAADAVDN 2535
            |:..:.:::.:.::::.:|.|::.::.:..:::.|.|.....:......|..|   .|....::.
Human   745 LKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACKADKTLATQRRLEE 809

  Fly  2536 LQQQQ---QKIAPPTYGSDMATFMQHQMQQPPKTD------------------TLINPLKRPGEE 2579
            .|:||   :::..||  .||. ...||    |..|                  |::..|...|:.
Human   810 RQRQQMILEEMKKPT--EDMC-LTDHQ----PLPDFSRVPGLTLPSGAFSDCLTIVEFLHSFGKV 867

  Fly  2580 IGMDYSGNAANKMQKREETPAQQ-------QQQQQQQQPTQNQTQSLLNK------QQQMFNSFL 2631
            :|.|               ||:.       |:....|..:..:.|.||.:      ....|.|:.
Human   868 LGFD---------------PAKDVPSLGVLQEGLLCQGDSLGEVQDLLVRLLKAALHDPGFPSYC 917

  Fly  2632 GTM-AFGKPIGNI--APDKAFEMYNRAAAMGFPKDFAKDNSC-QLQQQQQQQQSPQ--------- 2683
            .:: ..|:.:..|  ..|...|:. |...|.:..:.|   .| :|:.|..|.|.||
Human   918 QSLKILGEKVSEIPLTRDNVSEIL-RCFLMAYGVEPA---LCDRLRTQPFQAQPPQQKAAVLAFL 978

  Fly  2684 --------VTTNKQQANQQTQQQPQQQSQQSQPHLTQLQTALSQNYQQQQQQTQAQK--LPQQQQ 2738
                    :..|:.....::....::.....:..|.:|:|.|::...:.:.:.:..:  |.:::.
Human   979 VHELNGSTLIINEIDKTLESMSSYRKNKWIVEGRLRRLKTVLAKRTGRSEVEMEGPEECLGRRRS 1043

  Fly  2739 QQPPQQLNYQQQQAQLNHNYTAQQQATAVPDKPPAAQSTVAAAVSESSSNMMNLPSTAHQHHLSQ 2803
            .:..::.:..:::.:       ::...|||.:.......|.|..|       ::|....|.....
Human  1044 SRIMEETSGMEEEEE-------EESIAAVPGRRGRRDGEVDATAS-------SIPELERQIEKLS 1094

  Fly  2804 THHLAAYNKPTPPPPQTYSNPLMQSMLGYAGNYFDKTMPPAAHMYSASSSAASAYGNPAQQLP-- 2866
            ...|                            :|.|.:..::.|..|.|.....|......||
Human  1095 KRQL----------------------------FFRKKLLHSSQMLRAVSLGQDRYRRRYWVLPYL 1131

  Fly  2867 ---------GNYVP----------------GNNNPAHQQQQQPQQQQQQQQQAPAVPPAEVKAPA 2906
                     ||.||                .:.|||    ....:.:.......|..||..:.
Human  1132 AGIFVEGTEGNLVPEEVIKKETDSLKVAAHASLNPA----LFSMKMELAGSNTTASSPARARG-- 1190

  Fly  2907 KRGRKKKAATIAAEAAAAAAKQQQQQQQQQQQQAQQQQQVAAQQQHQQQQVSAQQQQQQHQQVAA 2971
             |.||.|..::......:..:.|..:|.|.|.|.:.|....||.|.|     .|.|.|.|:....
Human  1191 -RPRKTKPGSMQPRHLKSPVRGQDSEQPQAQLQPEAQLHAPAQPQPQ-----LQLQLQSHKGFLE 1249

  Fly  2972 QQQQHQAM--PQYNMPQSMASAAAATNNQLQAHAQALQQGFQLYAGLKSGGVSSPVGSSAATPVN 3034
            |:....::  .|:::.|   ||..:..:|.|:|                   ||.:.||..||.:
Human  1250 QEGSPLSLGQSQHDLSQ---SAFLSWLSQTQSH-------------------SSLLSSSVLTPDS 1292

  Fly  3035 SGGS--------------TTNQTAADAAAISLKTSTGGMVPGSAFNFAPTPGTLGLYGDQAAAAS 3085
            |.|.              ...:::.|..|:....|  ..:|   .|.||||
Human  1293 SPGKLDPAPSQPPEEPEPDEAESSPDPQALWFNIS--AQMP---CNAAPTP-------------- 1338

  Fly  3086 SYLDQFRDAPNPYYMPPAPAHSGTAANPSGNAADKGQNPLNTAAGSYPFLAAAHPSSRAAAAAAA 3150
                           |||.:......:|..                   ||::.|.:|.:||...
Human  1339 ---------------PPAVSEDQPTPSPQQ-------------------LASSKPMNRPSAANPC 1369

  Fly  3151 YPFADPNSQLYQQYLRRDDFHTRMIFNQSLLGGPAAAAAAAGYGQPPPPPSAYQRAALGMPK 3212
            .|                     :.|:.:.|.|.|....|...|:.|..|:     .||.||
Human  1370 SP---------------------VQFSSTPLAGLAPKRRAGDPGEMPQSPT-----GLGQPK 1405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246
dikar	NP_001261480.1	Bromo_gcn5_like	892..991	CDD:99941
BAZ2A	XP_011536103.1	HAT_MBD	551..623	CDD:238691	6/71 (8%)
		DDT	848..913	CDD:214726	12/79 (15%)
		WHIM3	1439..1477	CDD:292248
		PHD_BAZ2A	1685..1731	CDD:277099
		Bromo_BAZ2A_B_like	1805..1901	CDD:99935
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900