Protein Alignment dikar and BRD8

DIOPT Version :9

• Sequence 1: NP_001261480.1
• Gene: dikar / 38747
• FlyBaseID: FBgn0261934
• Length: 3261
• Species: Drosophila melanogaster
• Sequence 2: NP_631938.2
• Gene: BRD8 / 10902
• HGNCID: 19874
• Length: 1235
• Species: Homo sapiens
• Alignment Length: 1013
• Identity: 201/1013 - (19%)
• Similarity: 354/1013 - (34%)
• Gaps: 319/1013 - (31%)

  Fly   563 QLLDTNSAAIAVATSIAD-----LSLPSPVAHESETEQDEQVDQPAVVEAQPPALT--------- 613
            ::||.  ||:..|.|..:     .|||.|..|..:.|:|:.|..||      |.:|
Human   432 EVLDV--AAVEAALSFCEENDDPQSLPGPWEHPIQQERDKPVPLPA------PEMTVKQERLDFE 488

  Fly   614 -----------SAMAPAANVKLPGRQTNNSLSS---LTGNIFIPSGSAQQQQQQSQEPPSSSSSS 664
                       ....|:|.:|:...:....:|.   :.|  .:|:.|.:..:.:||:......|:
Human   489 ETENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG--VVPATSMEPPELRSQDLDEELGST 551

  Fly   665 QSGTTTTASTVRSKKQKAVLNSSGSSSTSKMADKADRNLSKTETTGKSKKSAA-GSSASSSSSKA 728
            .:|....|.....|..:..|.:                 .|||.:.:|..|.: ||:......:|
Human   552 AAGEIVEADVAIGKGDETPLTN-----------------VKTEASPESMLSPSHGSNPIEDPLEA 599

  Fly   729 E-----RISGAYSDKSGDDHVNSSNRSTTNNNSSLNNNNNHKHAPHHSHNNNNNSHSTTTSATTT 788
            |     .:|.:..::||           |...|.:      |.||    ..:......:.:|:..
Human   600 ETQHKFEMSDSLKEESG-----------TIFGSQI------KDAP----GEDEEEDGVSEAASLE 643

  Fly   789 ATTTTSQGYHYNSNLNHNQNHQNSHSHHTHHHHHHHHHTTNNHSNKHKTKSHHSLAHNNNNNNSP 853
            ......||..|.|.:::......|....:.|               :.|...|:||      :|.
Human   644 EPKEEDQGEGYLSEMDNEPPVSESDDGFSIH---------------NATLQSHTLA------DSI 687

  Fly   854 TTNPTSTSLLHPVTTNNNSTYNSSNHANILSFTETEEVLQIG--MHKVLVYV----KNHRDAWPF 912
            .::|.|:..                  ::.|  |.:|.:|..  ..|.::.|    .|||.|..|
Human   688 PSSPASSQF------------------SVCS--EDQEAIQAQKIWKKAIMLVWRAAANHRYANVF 732

  Fly   913 VDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMV 977
            :.||.:||||.|:||::|||||..::..:::|.....:||:.|..|:..|..:||..:::...|.
Human   733 LQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMA 797

  Fly   978 NNLQ-DAFEK-----ATKKYFDNLSDDEDDDPNLSYPAADSKMNVFREKYFSKKAKEETEKDA-- 1034
            ..:| |..|:     ||:.....           |.....:|....|:   |.:.::.:|||:
Human   798 VEMQRDVLEQIQQFLATQLIMQT-----------SESGISAKSLRGRD---STRKQDASEKDSVP 848

  Fly  1035 PGRPA-----VSSAEEDLSEIEAEAPQKAQKRKRKEKDKRRK-KKTKSKADV------ETDDEDM 1087
            .|.||     ....|....:.|.:.|..::    ...|.|.. ....|..|:      ||:|.:.
Human   849 MGSPAFLLSLFMGHEWVWLDSEQDHPNDSE----LSNDCRSLFSSWDSSLDLDVGNWRETEDPEA 909

  Fly  1088 EAEREPTPPPPPPTSKKSKTSKTGKEKEKDKEKEKDKDKEKDKETSSFKRGRKTKSDK------- 1145
            |...|.:|                 |:|..:....|...|:.:|.:     ||.....
Human   910 EELEESSP-----------------EREPSELLVGDGGSEESQEAA-----RKASHQNLLHFLSE 952

  Fly  1146 ----------SASKSSK------KTKKGAKKSSADSDPESDPSDSRESEDYSDDDHISLAKTKSL 1194
                      |:::||:      .|::..::..|.   |.:....||:|:.|       ||...|
Human   953 VAYLMEPLCISSNESSEGCCPPSGTRQEGREIKAS---EGERELCRETEELS-------AKGDPL 1007

  Fly  1195 VKPTARTIAAQKKKSVPAESKVKMPTPVKRQVKG---KGKGGRKAKDDSLDSDQSDVNVKKQLPP 1256
            |        |:|......:.:|.....|...|:|   :.:.| :|:.:|...||.:|.|
Human  1008 V--------AEKPLGENGKPEVASAPSVICTVQGLLTESEEG-EAQQESKGEDQGEVYV------ 1057

  Fly  1257 TAAAALAESAAELEEDPDDPPPDEDEDEDSSRSRSMSPFKVDLHKKYSKSALNDDLSELLTTVKK 1321
                      :|:|   |.||..|.:|                       |.|         :|:
Human  1058 ----------SEME---DQPPSGECDD-----------------------AFN---------IKE 1077

  Fly  1322 VPTAET-------TKLSARHQDE--ADEERSSRESDGDFKSLSNSRGSSEERPPVAKKGKKAESS 1377
            .|..:|       :||:...||:  .|.....:.....:|.:::.|.||....||:   ::....
Human  1078 TPLVDTLFSHATSSKLTDLSQDDPVQDHLLFKKTLLPVWKMIASHRFSSPFLKPVS---ERQAPG 1139

  Fly  1378 KKEKEKKGRD---KDRDRDKEKDKDKSRSAKDKKSKDESPVLV---------AAAEAAAVVQAEL 1430
            .|:..|:..|   ..|:..|.:.:..::..:|.....::.|:.         .|.|....|..::
Human  1140 YKDVVKRPMDLTSLKRNLSKGRIRTMAQFLRDLMLMFQNAVMYNDSDHHVYHMAVEMRQEVLEQI 1204

  Fly  1431 DMLLPFMDKYDVIKYRRSRAAFSGSSASNSLAPSEDSK 1468
            .:|..::||      |:..::..|..|:    |.:|.|
Human  1205 QVLNIWLDK------RKGSSSLEGEPAN----PVDDGK 1232

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246
		Bromo_gcn5_like	892..991	CDD:99941	36/110 (33%)
BRD8	NP_631938.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	186..205
		termin_org_DnaJ	<302..>681	CDD:274808	57/311 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	551..597		11/62 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	621..672		10/60 (17%)
		Bromo_brd8_like	709..812	CDD:99939	33/102 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	827..848		6/23 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	903..940		11/58 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	966..999		7/35 (20%)
		Bromo_brd8_like	1105..1208	CDD:99939	16/105 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900