DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dikar and cecr2

DIOPT Version :9

Sequence 1:	NP_001261480.1	Gene:	dikar / 38747	FlyBaseID:	FBgn0261934	Length:	3261	Species:	Drosophila melanogaster
Sequence 2:	XP_031754453.1	Gene:	cecr2 / 100486642	XenbaseID:	XB-GENE-6461178	Length:	1235	Species:	Xenopus tropicalis

Alignment Length:	2549	Identity:	413/2549 - (16%)
Similarity:	614/2549 - (24%)	Gaps:	1413/2549 - (55%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IGLL-DIQSWWEIPCISHFCSLFSSAFDLPDIDIEDLESALLSDGTSDEDQVALVPELIVRLLKG 69
            :|.| :::|.|.:|.|:||||||.:||.|||.:||:||.||      ..:.|..:.||:..||:|
Frog     4 VGALGELRSCWRVPAIAHFCSLFRTAFQLPDFEIEELEEAL------HRNDVEFLSELVACLLQG 62

  Fly    70 CDALQTVAKEITHSNYQMFLRRFLRQQCRLHQTENHFDTDIDFQSLPVRKRLHILHDLCHFRLDS 134
            |    ...::||...:.::|...:..:..:.:.:.:......|..|.:|.||.|||.||.:|||:
Frog    63 C----YQRRDITLQTFHVYLEDIISYRWEMEEGKPNPLRGTTFHQLELRTRLEILHRLCDYRLDA 123

  Fly   135 VDVQVILSNLEADSLRVEPLGYDAKNSGYWYFYGTRLYREDKATG------GSASSSSGSGSGGA 193
            .||..:|..|:.|||||||||.|:..:.||||||||||:|:.:..      ..||.:........
Frog   124 DDVFDLLKGLDGDSLRVEPLGEDSSGNLYWYFYGTRLYKEEPSWEKRQRLLEQASKNQEKPVRKR 188

  Fly   194 GAS-----------------------TGGASNSKGIGSNGTVWQVICFTEEDWQNLAAKFKTSTN 235
            |..                       ....|:.||.......|.::|.||::|:.:...|:...:
Frog   189 GRPPKKKKPVEEELLLSEKMDPKPPVVDEISDMKGCSPGEGSWSLLCQTEQEWREVTDSFRDKVS 253

  Fly   236 AKERELFNILDDNFLPKLPQLFRERERLRRRKLLQVRNSSRIRNIAELKARQEEERQRRERENLY 300
            ..||:|:.:|.:.|||::..:..::|             ::|
Frog   254 HNERQLYKLLSEEFLPEICNMISQKE-------------TKI----------------------- 282

  Fly   301 QDRQNAHWLAPPQQQQQQQQQQQQQQQQSQQRTRRRSQSTSTASGISTYASSLRRTTTTNSSEFL 365
                                    |::|::..::|.|:           .|.||
Frog   283 ------------------------QKEQAEIASKRLSE-----------RSGLR----------- 301

  Fly   366 CHRETFCLSPENDEDDDDDDEALDAEQQSDQPEQQRQQEEQPPEEEQRQEPEELLAVSATDDDFR 430
                    .||.|.:.....|.                     :||:|.    ||||...:.:.|
Frog   302 --------DPEQDHNPLGGHEG---------------------DEERRL----LLAVQRKEQELR 333

  Fly   431 SPEAPKSQTPAELKSKSSHHHHHHHHKKKKSSKKQKKRHHR----DKGRERDREHHHHHRRRHKH 491
            ..|..|......:||....            ::::|.|..|    .:|::...|..|
Frog   334 LKEERKRAMAERVKSVEDR------------AQRRKLREERAWLLSQGKQLPPELRH-------- 378

  Fly   492 ASEADEGEDDNNNHNSNSNSNSNTNSISSNNSVQPKRRRSGQQQQHHQQAETTEPSTSLSPEDKE 556
                                            ::|:
Frog   379 --------------------------------LEPR----------------------------- 382

  Fly   557 NFCRQLQLLDTNSAAIAVATSIADLSLPSPVAHESETEQDEQVDQPAVVEAQPPALTSAMAPAAN 621
                                        |||    ||:..
Frog   383 ----------------------------SPV----ETDYG------------------------- 390

  Fly   622 VKLPGRQTNNSLSSLTGNIFIPSGSAQQQQQQSQEPPSSSSSSQSGTTTTASTVRSKKQKAVLNS 686
                           ||::|            |.|.
Frog   391 ---------------TGDLF------------SFEL----------------------------- 399

  Fly   687 SGSSSTSKMADKADRNLSKTETTGKSKKSAAGSSASSSSSKAERISGAYSDKSGDDHVNSSNRST 751
                                                                  |||..:
Frog   400 ------------------------------------------------------DDHYTA----- 405

  Fly   752 TNNNSSLNNNNNHKHAPHHSHNNNNNSHSTTTSATTTATTTTSQGYHYNSNLNHNQNHQNSHSHH 816

Frog   406 ----------------------------------------------------------------- 405

  Fly   817 THHHHHHHHHTTNNHSNKHKTKSHHSLAHNNNNNNSPTTNPTSTSLLHPVTTNNNSTYNSSNHAN 881

Frog   406 ----------------------------------------------------------------- 405

  Fly   882 ILSFTETEEVLQIGMHKVLVYVKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEY 946
                          |:|||..||.|:|:|||::||:|..||.||:||..||||.::|.:|.||.|
Frog   406 --------------MYKVLDAVKAHKDSWPFLEPVDESYAPNYYNIITCPMDLSRVEQRLCSGYY 456

  Fly   947 HKFSEFRNDFRLIVNNCRLYNGHNNEYTEMVNNLQDAFEKATKKYFDNLSDDEDDDPNLSYPAAD 1011
            ....:|.||.::|..||..|||.::|||||.:||:..|:||..|:   |.:||.:....::
Frog   457 LTKEQFVNDMKIIFKNCAKYNGQDSEYTEMADNLERCFKKAMLKH---LPEDEGESDGETW---- 514

  Fly  1012 SKMNVFREKYFSKKAKEETEKDAPGRPAVSSAEEDLSEIEAEAPQKAQKRKRKEKDKRRKKKTKS 1076
                                                  |..|           ||::..|:|:
Frog   515 --------------------------------------IHVE-----------EKERPLKRKS-- 528

  Fly  1077 KADVETDDEDMEAEREPTPPPPPPTSKKSKTSKTGKEKEKDKEKEKDKDKEKDKETSSFKRGRKT 1141
                                    ..::||..  |.:|.:|       |.|:.:::|...|
Frog   529 ------------------------LGRRSKVG--GWQKSRD-------DSERKRQSSESSR---- 556

  Fly  1142 KSDKSASKSSKKTKKGAKKSSADSDPESDPSDSRESEDYSDDDHISLAKTKSLVKPTARTIAAQK 1206
                                       :.||..|:.|   .:.|..
Frog   557 ---------------------------ASPSTPRQEE---SERHYG------------------- 572

  Fly  1207 KKSVPAESKVKMPTPVKRQVKGKGKGGRKAKDDSLDSDQSDVNVKKQLPPTAAAALAESAAELEE 1271
                                                            ||..|
Frog   573 ------------------------------------------------PPAMA------------ 577

  Fly  1272 DPDDPPPDEDEDEDSSRSRSMSPFKVDLHKKYSKSALNDDLSELLTTVKKVPTAETTKLSARHQD 1336
                                 ||:...||  |...|
Frog   578 ---------------------SPYPHQLH--YGGMA----------------------------- 590

  Fly  1337 EADEERSSRESDGDFKSLSNSRGSSEERPPVAKKGKKAESSKKEKEKKGRDKDRDRDKEKDKDKS 1401
                                 |.|...|...:..|.:|.....|
Frog   591 ---------------------RQSLHPRDMPSAPGMQAPLRSSE--------------------- 613

  Fly  1402 RSAKDKKSKDESPVLVAAAEAAAVVQAELDMLLPFMDKYDVIKYRRSRAAFSGSSASNSLAPSED 1466
                        |.|                      .|..:::...:..          .|.:.
Frog   614 ------------PGL----------------------SYGALRFPEPQLG----------DPVQQ 634

  Fly  1467 SKSAITKSNRENRKASAKREKSPDAVENKRGRKSKDQKRSKESDKAEKSDKASKADTEKHSEKSK 1531
            ::|..|::             |||..|                  |..|:.|:    .:||
Frog   635 TQSYRTQA-------------SPDVPE------------------ASDSNPAN----FRHS---- 660

  Fly  1532 KKEEPPKVVEKAQREKSPAPVSALETIKEPPAPTPIATSASGKVKEG---------PAKKEPKKR 1587
                                       :.|..| |.:...||..:||         |....|:.|
Frog   661 ---------------------------RGPHVP-PNSARMSGPSQEGGRLYPQAQYPMGYMPQMR 697

  Fly  1588 ---PDKQMPPPPKPADKSSEKGSGKKSSSKKAAQKAGQPQTNNNTNLEALDVETEQTLKDINRWL 1649
               ||.::||          :|.|      .|..:.|||....|.|.
Frog   698 PGLPDGRVPP----------QGPG------SAPFQLGQPSAAWNGNC------------------ 728

  Fly  1650 EHTPRFTEFSSASNSPSRYNLLDDFDSGIGSKLDAADFRRPVALAAPKAELVPTKLAEALNELVS 1714
              .||          |.:|          |:.:|....|
Frog   729 --PPR----------PQQY----------GAPMDPRMVR-------------------------- 745

  Fly  1715 EPKEAVSKSESESVAPTPSSVSSSCGTPPHSMHSG-NSIGSTSATAASSSNCSNNSMPTPLPVAV 1778
                                       ||.|:.:| |:.||          ..|:.|.:|..||:
Frog   746 ---------------------------PPDSVCNGRNTFGS----------AGNSMMDSPEMVAM 773

  Fly  1779 TPTPTPAPPPLLPIPKPKEPSTTQLILNPPPPPHIKQQLAKEAKRKSLKEKQAAQAAQAQQVKAK 1843
            ....:.:.||....|.|..|:        |.||                             ...
Frog   774 QRLSSLSGPPSSAYPLPLGPA--------PYPP-----------------------------SGA 801

  Fly  1844 ANVMRTIDRLQPGKAKGNLLQNVVAVKSTEEGGDSHAGVNPVTTKVKELKNALITETCEGAPKLS 1908
            ...|...|..||..        |...|:|..|
Frog   802 PGTMNGPDMCQPSA--------VNRAKTTAPG--------------------------------- 825

  Fly  1909 LGTVLKTQDFSLGKSLEEMSGKKDANEDDRPNEEASPKNSSPPTTPNTEAPKPFEALHELSKRGK 1973
                                        |:.:.....|..||||.|.       :||       .
Frog   826 ----------------------------DKASSPGDSKPKSPPTAPT-------QAL-------M 848

  Fly  1974 SSEPSKSEASQKEKPNLSAWLKAFGGPKVSKKSEDEEKQQTPVQDLQGDSKVAPPAHSPAGDNFS 2038
            :.:...|...|...||.       |.|.|. ...|:|||..|....|..:..||  |.  |.|.:
Frog   849 NGDDGPSPLPQVPPPNQ-------GNPGVG-AFRDQEKQWGPTGGTQDGASSAP--HQ--GPNNA 901

  Fly  2039 LPTVMRQRKPSTGSTNSERSSFSQDPDSPRIAIDERYGSYAAGSYTSPIGASPIGASPIMVSPKP 2103
            :        ..|......:.|..:.|.|                       .||.|        |
Frog   902 V--------EGTAEVGQSKESLKEAPKS-----------------------EPITA--------P 927

  Fly  2104 NDDMGKPASPYPLNGAIKVGFYQD--TTTKSSPDKSCSPREMNSPYPQYSQHIYSSASSPNVSTP 2166
            ..|:.:|..     ||..|.....  :|...:|.....|....||:|
Frog   928 RKDVARPQP-----GAETVSNLATLLSTASHNPGVVRPPGAYPSPFP------------------ 969

  Fly  2167 DMSGTSPYGGGNSYNPSGSEASKTPAYSSTSPLPIYDQYKQPRSQESDYNSSMSPSTPNPHSPYQ 2231
                ...||.|:.....||    .|.|....|...|.::.|....              |:.|||
Frog   970 ----PQRYGNGHPQIAPGS----YPRYPHQDPSYPYQRHPQQGHP--------------PYQPYQ 1012

  Fly  2232 QPQSSP--YT---TPQQSQST--HPSPYHN-----------QSPYHQQQHSPYHPP------AAQ 2272
            ||...|  ||   .|.|.:.|  ||.|..|           .||..:.:  |...|      |.:
Frog  1013 QPPYYPREYTRWPQPPQQRGTYPHPGPPQNLQGMGELRSLLMSPLLEGE--PKAVPGEAKVQAEE 1075

  Fly  2273 QQQQSSQPSHSPAAHQQALSPMHSVESPASSAATQPPTPLAQSPAEQQHSPYQQPVLSP--YQQP 2335
            :.|:|...|..|.:.:|.|. :.|.:....|...:.|.|..........:...||...|  :.:|
Frog  1076 EGQRSEGGSDRPESPKQFLD-LDSHKRQCGSFGYEGPQPWGNGNFRPHPNVMPQPPYPPQHHYRP 1139

  Fly  2336 QQQVQPPVVPPVQPSAGAQASTALGNNGYAPTHDSYQQLQQQQ-----------------RSLYN 2383
            |...|||:..|..|   ..|.|    ||:|.....||.|...:                 :::|.
Frog  1140 QGYPQPPMHAPRHP---GHAET----NGHAALRPGYQNLDHNRGHFQAVMMEQSGNMPPFQNMYR 1197

  Fly  2384 PATLINPLSTAASSTASITKPNNDWSLNRSLLPPSITNTVNQAAQQQQQQQQQQAGQLQQQPQMQ 2448
            |.                       .:|..:.||:......|             |.:.|:|
Frog  1198 PQ-----------------------RMNFQMQPPAFPKATGQ-------------GDMVQKP--- 1223

  Fly  2449 AAQQQLQSTPQQQQ 2462
                  .|.||.||
Frog  1224 ------PSMPQDQQ 1231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246	17/47 (36%)
dikar	NP_001261480.1	Bromo_gcn5_like	892..991	CDD:99941	48/98 (49%)
cecr2	XP_031754453.1	DDT	6..61	CDD:397084	26/60 (43%)
		Bromo_gcn5_like	401..501	CDD:99941	50/248 (20%)
		PHA03247	<624..1071	CDD:223021	145/860 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	93	1.000	Domainoid score	I7459
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	311	1.000	Inparanoid score	I2545
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007388
OrthoInspector	1	1.000	-	-		oto104989
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5612
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.080