DRSC/TRiP Functional Genomics Resources

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Protein Alignment ple and TPH1

DIOPT Version :10

Sequence 1:NP_476898.1 Gene:ple / 38746 FlyBaseID:FBgn0005626 Length:579 Species:Drosophila melanogaster
Sequence 2:NP_004170.1 Gene:TPH1 / 7166 HGNCID:12008 Length:444 Species:Homo sapiens


Alignment Length:436 Identity:191/436 - (43%)
Similarity:289/436 - (66%) Gaps:8/436 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly   148 ESSDAEAAMQSAALVVRLKEGISSLGRILKAIETFHGTVQHVESRQSRVEGVDHDVLIKLDMTRG 212
            |:.|.......|:|:..||..:..|.:.||..:..|..:.|:|||:|:....:.::.:..|:.|.
Human     7 ENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINRE 71

  Fly   213 NLLQLIRSLRQSGSFSSMNLMADNNLNVK------APWFPKHASELDNCNHLMTKYEPDLDMNHP 271
            .|..:...|:...:..|:||  .:|..:|      .|||||..|:||:|.:.:..|..:||.:||
Human    72 QLNDIFHLLKSHTNVLSVNL--PDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHP 134

  Fly   272 GFADKVYRQRRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAFQK 336
            ||.|.|||:|||..|::|..||:|||||.:::::.|:|||.:||:.:..|.|.|||.||......
Human   135 GFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPL 199

  Fly   337 LQDEQIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSPYH 401
            |.....:.|..:|||:::|:||::.||||:||.||.|:.||||:.||||:|..||||||.:.|::
Human   200 LSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFY 264

  Fly   402 TPEPDSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEHGQIKA 466
            |||||:.||||||:||||:||||||||||||||||||:|.::||:|.|:|||||||||:.||::.
Human   265 TPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRV 329

  Fly   467 YGAGLLSSYGELLHAISDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAKDKFRRWVSTMS 531
            :|||||||..||.||:|...:.:.|:|..|..|......:|.:|:|:|||||||:|.|.:..|:.
Human   330 FGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIK 394

  Fly   532 RPFEVRFNPHTERVEVLDSVDKLETLVHQMNTEILHLTNAISKLRR 577
            |||.|::||:|..:::|.....:.:.::::..::..:::|::|:.|
Human   395 RPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSR 440

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pleNP_476898.1 Tyr_3_monoox 130..576 CDD:130336 190/433 (44%)
TPH1NP_004170.1 Trp_5_monoox 3..439 CDD:130337 190/433 (44%)

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