Protein Alignment ple and tph1b

DIOPT Version :9

• Sequence 1: NP_001286955.1
• Gene: ple / 38746
• FlyBaseID: FBgn0005626
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_001001843.2
• Gene: tph1b / 415103
• ZFINID: ZDB-GENE-030805-6
• Length: 480
• Species: Danio rerio
• Alignment Length: 454
• Identity: 203/454 - (44%)
• Similarity: 292/454 - (64%)
• Gaps: 18/454 - (3%)

  Fly   138 DEILLAN--------AASESSDAE--AAMQSAALVVRLKEGISSLGRILKAIETFHGTVQHVESR 192
            :|.||:|        ...|:.|.:  :..:.||:|..||..:..|.:.||..:.....:.|:|||
Zfish    23 EEKLLSNELRKTTFHKTDENKDKKLSSKREHAAIVFSLKNEVGGLVKALKLFQDNQVNLLHIESR 87

  Fly   193 QSRVEGVDHDVLIKLDMTRGNLLQLIRSLRQSGSFSSMN----LMADNNLNVKAPWFPKHASELD 253
            :||....:.:||:..|..|..|.::::.||:..|..:||    .....:...:.|||||..|:||
Zfish    88 KSRRRNSELEVLVDCDSDRETLKEIVQLLRKQTSIIAMNSPDKFWTPASDLTEVPWFPKKISDLD 152

  Fly   254 N--CNHLMTKYEPDLDMNHPGFADKVYRQRRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFK 316
            .  |..||  |..:||.:||||.|.|||:|||..|::|.:||:|||||.:::::.|||||..||:
Zfish   153 KSACRVLM--YGSELDADHPGFKDNVYRKRRKYFADLAMSYKHGDPIPHVEFTEEEVKTWGVVFR 215

  Fly   317 TVQDLAPKHACAEYRAAFQKLQDEQIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLAS 381
            .:..|.|.|||.||......|.....:.|..:|||:::|:|||:.|||::||.||.|:.|||||.
Zfish   216 ELNKLYPTHACREYLQNLPLLSQFCGYREDNIPQLEDVSNFLRERTGFTIRPVAGYLSPRDFLAG 280

  Fly   382 LAFRIFQSTQYVRHVNSPYHTPEPDSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLS 446
            ||||:|..||||||.:.|.:|||||:.||||||:||||:|||||||||:|||||||||:.::||:
Zfish   281 LAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQELGLASLGASDDAVQKLA 345

  Fly   447 TVYWFTVEFGLCKEHGQIKAYGAGLLSSYGELLHAISDKCEHRAFEPASTAVQPYQDQEYQPIYY 511
            |.|:|||||||||:.|.::|||||||||..||.|::||..:...|||..|..|......:|.:|:
Zfish   346 TCYFFTVEFGLCKQEGSLRAYGAGLLSSISELKHSLSDSAKILPFEPKVTCKQECLITTFQDVYF 410

  Fly   512 VAESFEDAKDKFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLVHQMNTEILHLTNAISKL 575
            |:||||:||.:.|.:..|:.|||.:|:||:|:.|.||..:..:..:|.::..|:..:.:|:.:|
Zfish   411 VSESFEEAKCRMREFAKTIQRPFSLRYNPYTQSVCVLKDMPSINDVVEELRHELDIVGDALCRL 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ple	NP_001286955.1	Tyr_3_monoox	130..576	CDD:130336	203/454 (45%)
		ACT	130..234	CDD:298841	30/109 (28%)
		Biopterin_H	243..573	CDD:278766	172/331 (52%)
tph1b	NP_001001843.2	Trp_5_monoox	52..475	CDD:130337	197/425 (46%)
		ACT_TPH	54..127	CDD:153201	23/72 (32%)
		Biopterin_H	142..471	CDD:278766	171/330 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820