Protein Alignment ple and tph2

DIOPT Version :10

• Sequence 1: NP_476898.1
• Gene: ple / 38746
• FlyBaseID: FBgn0005626
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_001296997.1
• Gene: tph2 / 407712
• ZFINID: ZDB-GENE-040624-4
• Length: 546
• Species: Danio rerio
• Alignment Length: 530
• Identity: 200/530 - (37%)
• Similarity: 305/530 - (57%)
• Gaps: 48/530 - (9%)

  Fly    70 QAQEHIPSEQDVEL--QDEHANLENLPLEEYVPVEEDVEFESVEQEQSESQSQEPEGNQQPTKND 132
            :.||.||..|...:  ..::.....|.|:..:..::.:....:.:.......:.|:..:|.:.:|
Zfish    39 RGQEAIPKMQPAMMMFSSKYWARRGLSLDSAMYDQQHLASSMLRRTSFNRIDERPDKEEQKSTHD 103

  Fly   133 YGLTEDEILLANAASESSDAEAAMQSAALVVRLKEGISSLGRILKAIETFHGTVQHVESRQSRVE 197
            .|                       ..|::..||..:..|.:.|:..:..|..:.|:|||:|:..
Zfish   104 LG-----------------------KLAVIFSLKNEVGFLVKALRLFQEKHVNLAHIESRRSKRL 145

  Fly   198 GVDHDVLIKLDMTRGNLLQLIRSLRQSGSFSSMNL--------------------MADNNLNVKA 242
            ..:.::..:.:.|:....:|::.|:...:..|.|.                    :.|..   ..
Zfish   146 TNEIEIYAECNCTKKEFNELVQHLKDHVNIVSYNTPQHVWSAETDCLDCVCVLGGLPDGE---GI 207

  Fly   243 PWFPKHASELDNCNHLMTKYEPDLDMNHPGFADKVYRQRRKEIAEIAFAYKYGDPIPFIDYSDVE 307
            ||||:..||||.|:|.:..|..:||.:||||.|||||||||...|:|..||:|.|||.|:|:..|
Zfish   208 PWFPQKISELDQCSHRVLMYGSELDADHPGFKDKVYRQRRKYFVEVAMNYKFGQPIPRIEYTAEE 272

  Fly   308 VKTWRSVFKTVQDLAPKHACAEYRAAFQKLQDEQIFVETRLPQLQEMSDFLRKNTGFSLRPAAGL 372
            ||||..|::.:..|.|.|||.||......|.....:.|..:|||:::|.|||:.:||::||.||.
Zfish   273 VKTWGVVYRELTKLYPTHACREYLKNLPLLTKHCGYREDNIPQLEDVSLFLRERSGFTVRPVAGY 337

  Fly   373 LTARDFLASLAFRIFQSTQYVRHVNSPYHTPEPDSIHELLGHMPLLADPSFAQFSQEIGLASLGA 437
            |:.|||||.||:|:|..|||:||...|.:|||||:.||||||:||||||.|||||||||||||||
Zfish   338 LSPRDFLAGLAYRVFNCTQYIRHSTDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGA 402

  Fly   438 SDEEIEKLSTVYWFTVEFGLCKEHGQIKAYGAGLLSSYGELLHAISDKCEHRAFEPASTAVQPYQ 502
            |||:::||:|.|:||:||||||:.||::.||||||||.|||.||:|||...:.|:|.:|..|...
Zfish   403 SDEDVQKLATCYFFTIEFGLCKQDGQLRVYGAGLLSSIGELRHALSDKATVKVFDPKTTCYQECL 467

  Fly   503 DQEYQPIYYVAESFEDAKDKFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLVHQMNTEILH 567
            ...:|.:|:|:||||:||:|.|.:..::.|||.|.:||:|:.:::|.....:|.:|..:.:::..
Zfish   468 ITTFQDVYFVSESFEEAKEKMREFAKSIKRPFSVYYNPYTQSIDLLKDTRSIENVVQDLRSDLTT 532

  Fly   568 LTNAISKLRR 577
            :.:|:.|:.:
Zfish   533 VCDALGKMNK 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ple	NP_476898.1	Tyr_3_monoox	130..576	CDD:130336	191/465 (41%)
tph2	NP_001296997.1	Trp_5_monoox	84..541	CDD:130337	193/482 (40%)