DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ple and tph1a

DIOPT Version :9

Sequence 1:	NP_001286955.1	Gene:	ple / 38746	FlyBaseID:	FBgn0005626	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_840091.2	Gene:	tph1a / 352943	ZFINID:	ZDB-GENE-030317-1	Length:	483	Species:	Danio rerio

Alignment Length:	485	Identity:	210/485 - (43%)
Similarity:	306/485 - (63%)	Gaps:	33/485 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 SQSQEPEGNQQPTKNDYGLTEDEILLANAASESS------DAEAAMQS-----AALVVRLKEGIS 170
            |:|..|...:.....:.|:|.:|..|.|..::|:      :.:...:|     ||:|..||..:.
Zfish     4 SKSDGPRRGRSFDSMNLGMTLEEKQLNNEMNKSAFTKIEENKDNKTESSETGRAAVVFSLKNEVG 68

  Fly   171 SLGRILKAIETFHGTVQHVESRQSRVEGVDHDVLIKLDMTRGNLLQLIRSLRQSGSFSSMNLMAD 235
            .|.:.||..:..|..:.|:|||:|:....:.::.:..|..|..|.::|:.||:..:...|: ..|
Zfish    69 GLVKALKLFQENHVNLVHIESRKSKRRNSEFEIFVDCDSNREQLHEIIQLLRKHVNVVEMD-APD 132

  Fly   236 NNL-------NVKAPWFPKHASELDNCNHLMTKYEPDLDMNHPGFADKVYRQRRKEIAEIAFAYK 293
            |.|       ||  |||||..|:||.|.:.:..|..|||.:||||.|.|||:|||..|::|.:||
Zfish   133 NRLPEESEMENV--PWFPKKISDLDKCANRVLMYGSDLDADHPGFKDNVYRKRRKYFADLAMSYK 195

  Fly   294 YGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAFQKLQDEQIFV------ETRLPQLQ 352
            :|||||.|::::.|||||..||:.:..|.|.|||.||      |::..:.:      |..:|||:
Zfish   196 HGDPIPRIEFTEEEVKTWGVVFRELNKLYPSHACREY------LKNLPLLIKHCDSREDNIPQLE 254

  Fly   353 EMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSPYHTPEPDSIHELLGHMPL 417
            ::|.||::.|||::||.||.|:.|||||.||||:|..||||||.:.|.:|||||:.||||||:||
Zfish   255 DVSRFLKERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPL 319

  Fly   418 LADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEHGQIKAYGAGLLSSYGELLHAI 482
            ||:|||||||||||||||||||:.|:||:|.|:|||||||||:.|:::|||||||||..||.||:
Zfish   320 LAEPSFAQFSQEIGLASLGASDDSIQKLATCYFFTVEFGLCKQEGKLRAYGAGLLSSISELKHAL 384

  Fly   483 SDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAKDKFRRWVSTMSRPFEVRFNPHTERVEV 547
            |.......|:|..|..|......:|.:|::::|||:||.|.|.:..|:.|||.||:||:|:.|:|
Zfish   385 SGNARILPFDPNVTCKQECIITTFQDVYFMSDSFEEAKVKMREFAKTIKRPFSVRYNPYTQSVDV 449

  Fly   548 LDSVDKLETLVHQMNTEILHLTNAISKLRR 577
            |.....:..:|.::..|:..:.:|:|:|.:
Zfish   450 LKDTTSINNVVEELRHELDIIGDALSRLNK 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ple	NP_001286955.1	Tyr_3_monoox	130..576	CDD:130336	206/469 (44%)
		ACT	130..234	CDD:298841	28/114 (25%)
		Biopterin_H	243..573	CDD:278766	172/335 (51%)
tph1a	NP_840091.2	Trp_5_monoox	50..478	CDD:130337	200/436 (46%)
		ACT_TPH	57..130	CDD:153201	21/73 (29%)
		Biopterin_H	145..475	CDD:278766	172/335 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820