Protein Alignment ple and tph1a

DIOPT Version :10

• Sequence 1: NP_476898.1
• Gene: ple / 38746
• FlyBaseID: FBgn0005626
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_840091.2
• Gene: tph1a / 352943
• ZFINID: ZDB-GENE-030317-1
• Length: 483
• Species: Danio rerio
• Alignment Length: 485
• Identity: 210/485 - (43%)
• Similarity: 306/485 - (63%)
• Gaps: 33/485 - (6%)

  Fly   117 SQSQEPEGNQQPTKNDYGLTEDEILLANAASESS------DAEAAMQS-----AALVVRLKEGIS 170
            |:|..|...:.....:.|:|.:|..|.|..::|:      :.:...:|     ||:|..||..:.
Zfish     4 SKSDGPRRGRSFDSMNLGMTLEEKQLNNEMNKSAFTKIEENKDNKTESSETGRAAVVFSLKNEVG 68

  Fly   171 SLGRILKAIETFHGTVQHVESRQSRVEGVDHDVLIKLDMTRGNLLQLIRSLRQSGSFSSMNLMAD 235
            .|.:.||..:..|..:.|:|||:|:....:.::.:..|..|..|.::|:.||:..:...|: ..|
Zfish    69 GLVKALKLFQENHVNLVHIESRKSKRRNSEFEIFVDCDSNREQLHEIIQLLRKHVNVVEMD-APD 132

  Fly   236 NNL-------NVKAPWFPKHASELDNCNHLMTKYEPDLDMNHPGFADKVYRQRRKEIAEIAFAYK 293
            |.|       ||  |||||..|:||.|.:.:..|..|||.:||||.|.|||:|||..|::|.:||
Zfish   133 NRLPEESEMENV--PWFPKKISDLDKCANRVLMYGSDLDADHPGFKDNVYRKRRKYFADLAMSYK 195

  Fly   294 YGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAFQKLQDEQIFV------ETRLPQLQ 352
            :|||||.|::::.|||||..||:.:..|.|.|||.||      |::..:.:      |..:|||:
Zfish   196 HGDPIPRIEFTEEEVKTWGVVFRELNKLYPSHACREY------LKNLPLLIKHCDSREDNIPQLE 254

  Fly   353 EMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSPYHTPEPDSIHELLGHMPL 417
            ::|.||::.|||::||.||.|:.|||||.||||:|..||||||.:.|.:|||||:.||||||:||
Zfish   255 DVSRFLKERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPL 319

  Fly   418 LADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEHGQIKAYGAGLLSSYGELLHAI 482
            ||:|||||||||||||||||||:.|:||:|.|:|||||||||:.|:::|||||||||..||.||:
Zfish   320 LAEPSFAQFSQEIGLASLGASDDSIQKLATCYFFTVEFGLCKQEGKLRAYGAGLLSSISELKHAL 384

  Fly   483 SDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAKDKFRRWVSTMSRPFEVRFNPHTERVEV 547
            |.......|:|..|..|......:|.:|::::|||:||.|.|.:..|:.|||.||:||:|:.|:|
Zfish   385 SGNARILPFDPNVTCKQECIITTFQDVYFMSDSFEEAKVKMREFAKTIKRPFSVRYNPYTQSVDV 449

  Fly   548 LDSVDKLETLVHQMNTEILHLTNAISKLRR 577
            |.....:..:|.::..|:..:.:|:|:|.:
Zfish   450 LKDTTSINNVVEELRHELDIIGDALSRLNK 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ple	NP_476898.1	Tyr_3_monoox	130..576	CDD:130336	206/469 (44%)
tph1a	NP_840091.2	Trp_5_monoox	50..478	CDD:130337	200/436 (46%)