DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ple and Tph2

DIOPT Version :9

Sequence 1:	NP_001286955.1	Gene:	ple / 38746	FlyBaseID:	FBgn0005626	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_776211.1	Gene:	Tph2 / 317675	RGDID:	631332	Length:	485	Species:	Rattus norvegicus

Alignment Length:	489	Identity:	204/489 - (41%)
Similarity:	303/489 - (61%)	Gaps:	29/489 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 LPLEEYVPVEEDVEFESVEQEQSESQSQEPEGNQQPTKNDYGLTEDEILLANAASESSDAEAAMQ 157
            |.|:..||.|..:.....:.:.:.|:|::....:.                  .||||
  Rat    18 LSLDSAVPEEHQILGGLTQNKATASKSEDKRSGKD------------------TSESS------- 57

  Fly   158 SAALVVRLKEGISSLGRILKAIETFHGTVQHVESRQSRVEGVDHDVLIKLDMTRGNLLQLIRSLR 222
            ..|:|..||..:..|.|.|:..:..|..:.|:|||:||....:.::.:..:..:....:||:.|:
  Rat    58 KTAVVFSLKNEVGGLVRALRLFQEKHVNMLHIESRRSRRRSSEVEIFVDCECGKTEFNELIQLLK 122

  Fly   223 QSGSFSSM----NLMADNNLNVKAPWFPKHASELDNCNHLMTKYEPDLDMNHPGFADKVYRQRRK 283
            ...:..::    |:..:.......||||:..||||.|:|.:..|..:||.:||||.|.|||||||
  Rat   123 FQTTIVTLNPPDNIWTEEEELEDVPWFPRKISELDRCSHRVLMYGTELDADHPGFKDNVYRQRRK 187

  Fly   284 EIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAFQKLQDEQIFVETRL 348
            ...::|..||||.|||.::|::.|.|||..||:.:..|.|.|||.||...|..|.....:.|..:
  Rat   188 YFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNV 252

  Fly   349 PQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSPYHTPEPDSIHELLG 413
            |||:::|.||::.:||::||.||.|:.|||||.||:|:|..||||||.:.|.:|||||:.|||||
  Rat   253 PQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYVRHGSDPLYTPEPDTCHELLG 317

  Fly   414 HMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEHGQIKAYGAGLLSSYGEL 478
            |:||||||.||||||||||||||||||:::||:|.|:||:||||||:.||::|||||||||.|||
  Rat   318 HVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGEL 382

  Fly   479 LHAISDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAKDKFRRWVSTMSRPFEVRFNPHTE 543
            .||:|||...:||:|.:|.:|......:|..|:|:||||:||:|.|.:..:::|||.|.|||:|:
  Rat   383 KHALSDKACVKAFDPKTTCLQECLITTFQDAYFVSESFEEAKEKMRDFAKSITRPFSVYFNPYTQ 447

  Fly   544 RVEVLDSVDKLETLVHQMNTEILHLTNAISKLRR 577
            .:|:|.....:|.:|..:.:::..:.:|::|:.:
  Rat   448 SIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQ 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ple	NP_001286955.1	Tyr_3_monoox	130..576	CDD:130336	197/449 (44%)
		ACT	130..234	CDD:298841	22/107 (21%)
		Biopterin_H	243..573	CDD:278766	174/329 (53%)
Tph2	NP_776211.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..57		4/42 (10%)
		Trp_5_monoox	48..480	CDD:130337	197/456 (43%)
		ACT_TPH	59..132	CDD:153201	17/72 (24%)
		Biopterin_H	147..477	CDD:278766	174/329 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820