DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ple and Th

DIOPT Version :9

Sequence 1:	NP_001286955.1	Gene:	ple / 38746	FlyBaseID:	FBgn0005626	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	XP_038957248.1	Gene:	Th / 25085	RGDID:	3853	Length:	507	Species:	Rattus norvegicus

Alignment Length:	510	Identity:	244/510 - (47%)
Similarity:	337/510 - (66%)	Gaps:	44/510 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 PVEEDVEFESVEQEQSESQSQ---------EPE-----GNQQPTKNDYGLTEDEILLANAASESS 150
            |..:...|.....||...|::         .||     |.:|....| ...|.|...|.||:..:
  Rat     7 PSPQPKGFRRAVSEQDAKQAEAVTVRRICCHPESPRFIGRRQSLIED-ARKEREAAAAAAAAAVA 70

  Fly   151 DAEAAMQSAALVVRLKEG--------------ISSLGRILKAIETFHGTVQHVESR--QSRVEGV 199
            .:|......|:|...::|              .|||.|.:|..|||...:.|:|:|  |..:.|.
  Rat    71 SSEPGNPLEAVVFEERDGNAVLNLLFSLRGTKPSSLSRAVKVFETFEAKIHHLETRPAQRPLAGS 135

  Fly   200 DH-DVLIKLDMTRGNLLQLIRSLRQSGSFSSMNLMADNNLNV---KAPWFPKHASELDNCNHLMT 260
            .| :..::.::..|:|..|:.|:|:         ::|:..:.   |.||||:..||||.|:||:|
  Rat   136 PHLEYFVRFEVPSGDLAALLSSVRR---------VSDDVRSAREDKVPWFPRKVSELDKCHHLVT 191

  Fly   261 KYEPDLDMNHPGFADKVYRQRRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKH 325
            |::||||::||||:|:|||||||.||||||.||:|:|||.::|:..|:.||:.|:.|::.|...|
  Rat   192 KFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGEPIPHVEYTAEEIATWKEVYVTLKGLYATH 256

  Fly   326 ACAEYRAAFQKLQDEQIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQST 390
            ||.|:...||.|:....:.|..:|||:::|.||::.|||.|||.||||:|||||||||||:||.|
  Rat   257 ACREHLEGFQLLERYCGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCT 321

  Fly   391 QYVRHVNSPYHTPEPDSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEF 455
            ||:||.:||.|:||||..||||||:|:|||.:||||||:||||||||||||||||||||||||||
  Rat   322 QYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEF 386

  Fly   456 GLCKEHGQIKAYGAGLLSSYGELLHAISDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAK 520
            ||||::|::||||||||||||||||::|::.|.|||:|.:.||||||||.|||:|:|:|||.|||
  Rat   387 GLCKQNGELKAYGAGLLSSYGELLHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFNDAK 451

  Fly   521 DKFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLVHQMNTEILHLTNAISKL 575
            ||.|.:.|.:.|||.|:|:|:|..::||||...::..:..:..|:..|.:|:|.:
  Rat   452 DKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHTIQRSLEGVQDELHTLAHALSAI 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ple	NP_001286955.1	Tyr_3_monoox	130..576	CDD:130336	235/466 (50%)
		ACT	130..234	CDD:298841	29/120 (24%)
		Biopterin_H	243..573	CDD:278766	203/329 (62%)
Th	XP_038957248.1	TOH_N	2..26	CDD:403668	4/18 (22%)
		ACT_TH	47..167	CDD:153202	31/129 (24%)
		Biopterin_H	174..504	CDD:395280	203/329 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341387
Domainoid	1	1.000	440	1.000	Domainoid score	I531
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H307
Inparanoid	1	1.050	463	1.000	Inparanoid score	I1487
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	1	1.000	-	-		oto95666
orthoMCL	1	0.900	-	-		OOG6_108343
Panther	1	1.100	-	-	O	PTHR11473
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3954
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760