DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ple and Tph1

DIOPT Version :9

Sequence 1:	NP_001286955.1	Gene:	ple / 38746	FlyBaseID:	FBgn0005626	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001094104.1	Gene:	Tph1 / 24848	RGDID:	3895	Length:	444	Species:	Rattus norvegicus

Alignment Length:	434	Identity:	187/434 - (43%)
Similarity:	283/434 - (65%)	Gaps:	4/434 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 ESSDAEAAMQSAALVVRLKEGISSLGRILKAIETFHGTVQHVESRQSRVEGVDHDVLIKLDMTRG 212
            |:.|..:......|:..||..:..|.:.||..:..|..:.|:|||:|:....:.::.:..|:.|.
  Rat     7 ENKDHSSERGRVTLIFSLKNEVGGLIKALKIFQENHVNLLHIESRKSKRRNSEFEIFVDCDINRE 71

  Fly   213 NLLQLIRSLRQSGSFSSMN----LMADNNLNVKAPWFPKHASELDNCNHLMTKYEPDLDMNHPGF 273
            .|..:...|:...:..|::    |....::....|||||..|:||.|.:.:..|..:||.:||||
  Rat    72 QLNDIFPLLKSHTTVLSVDSPDQLPEKEDVMETVPWFPKKISDLDFCANRVLLYGSELDADHPGF 136

  Fly   274 ADKVYRQRRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAFQKLQ 338
            .|.|||:|||..||:|..||:|||||.|::::.|:|||.::|:.:..|.|.|||.||......|.
  Rat   137 KDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWGTIFRELNKLYPTHACREYLRNLPLLS 201

  Fly   339 DEQIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSPYHTP 403
            ....:.|..:|||:::|:||::.||||:||.||.|:.||||:.||||:|..||||||.:.|.:||
  Rat   202 KYCGYREDNVPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTP 266

  Fly   404 EPDSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEHGQIKAYG 468
            |||:.||||||:||||:||||||||||||||||||:|.::||:|.|:|||||||||:.||::.:|
  Rat   267 EPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGLCKQDGQLRVFG 331

  Fly   469 AGLLSSYGELLHAISDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAKDKFRRWVSTMSRP 533
            ||||||..||.||:|...:.:.|:|.....|......:|.:|:|:|||||||:|.|.:..|:.||
  Rat   332 AGLLSSISELRHALSGHAKVKPFDPKVACKQECLITSFQDVYFVSESFEDAKEKMREFAKTVKRP 396

  Fly   534 FEVRFNPHTERVEVLDSVDKLETLVHQMNTEILHLTNAISKLRR 577
            |.|::||:|:.::||.....:.:.::::..::..:.:|::::.|
  Rat   397 FGVKYNPYTQSIQVLRDSKSITSAMNELRHDLDVVNDALARVSR 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ple	NP_001286955.1	Tyr_3_monoox	130..576	CDD:130336	186/431 (43%)
		ACT	130..234	CDD:298841	20/89 (22%)
		Biopterin_H	243..573	CDD:278766	166/329 (50%)
Tph1	NP_001094104.1	Trp_5_monoox	3..439	CDD:130337	186/431 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820