DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ple and Th

DIOPT Version :9

Sequence 1:	NP_001286955.1	Gene:	ple / 38746	FlyBaseID:	FBgn0005626	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_033403.1	Gene:	Th / 21823	MGIID:	98735	Length:	498	Species:	Mus musculus

Alignment Length:	501	Identity:	244/501 - (48%)
Similarity:	334/501 - (66%)	Gaps:	51/501 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 SQSQEPEG-----NQQPTKNDYGLT-----------------EDEILLANAASESSDAEAAMQSA 159
            :.|.:|:|     ::|.||....:|                 |.|...|.||:..:.||......
Mouse     6 ASSPQPKGFRRAVSEQDTKQAEAVTSPRFIGRRQSLIEDARKEREAAAAAAAAAVASAEPGNPLE 70

  Fly   160 ALVVRLKEG--------------ISSLGRILKAIETFHGTVQHVESR--QSRVEGVDH-DVLIKL 207
            |:|...::|              .|||.|.||..|||...:.|:|:|  |..:.|..| :..::.
Mouse    71 AVVFEERDGNAVLNLLFSLRGTKPSSLSRALKVFETFEAKIHHLETRPAQRPLAGSPHLEYFVRF 135

  Fly   208 DMTRGNLLQLIRSLRQSGSFSSMNLMADNNLNV---KAPWFPKHASELDNCNHLMTKYEPDLDMN 269
            ::..|:|..|:.|:|:         ::|:..:.   |.||||:..||||.|:||:||::||||::
Mouse   136 EVPSGDLAALLSSVRR---------VSDDVRSAREDKVPWFPRKVSELDKCHHLVTKFDPDLDLD 191

  Fly   270 HPGFADKVYRQRRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAF 334
            ||||:|:.||||||.||||||.||.|:|||.::|:..|:.||:.|:.|::.|...|||.|:..||
Mouse   192 HPGFSDQAYRQRRKLIAEIAFQYKQGEPIPHVEYTKEEIATWKEVYATLKGLYATHACREHLEAF 256

  Fly   335 QKLQDEQIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSP 399
            |.|:....:.|..:|||:::|.||::.|||.|||.||||:|||||||||||:||.|||:||.:||
Mouse   257 QLLERYCGYREDSIPQLEDVSHFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSP 321

  Fly   400 YHTPEPDSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEHGQI 464
            .|:||||..||||||:|:|||.:||||||:||||||||||||||||||||||||||||||::|::
Mouse   322 MHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGEL 386

  Fly   465 KAYGAGLLSSYGELLHAISDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAKDKFRRWVST 529
            ||||||||||||||||::|::.|.|||:|.:.||||||||.|||:|:|:|||.|||||.|.:.|.
Mouse   387 KAYGAGLLSSYGELLHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFSDAKDKLRNYASR 451

  Fly   530 MSRPFEVRFNPHTERVEVLDSVDKLETLVHQMNTEILHLTNAISKL 575
            :.|||.|:|:|:|..::||||...:...:..:..|:..||.|:|.:
Mouse   452 IQRPFSVKFDPYTLAIDVLDSPHTIRRSLEGVQDELHTLTQALSAI 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ple	NP_001286955.1	Tyr_3_monoox	130..576	CDD:130336	239/483 (49%)
		ACT	130..234	CDD:298841	32/137 (23%)
		Biopterin_H	243..573	CDD:278766	204/329 (62%)
Th	NP_033403.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		7/26 (27%)
		TOH_N	2..26	CDD:289326	6/19 (32%)
		Tyr_3_monoox	38..495	CDD:130336	236/465 (51%)
		ACT_TH	38..158	CDD:153202	31/128 (24%)
		Biopterin_H	165..495	CDD:278766	204/329 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837664
Domainoid	1	1.000	441	1.000	Domainoid score	I544
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H307
Inparanoid	1	1.050	467	1.000	Inparanoid score	I1520
Isobase	1	0.950	-	0	Normalized mean entropy	S3178
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	1	1.000	-	-		oto92097
orthoMCL	1	0.900	-	-		OOG6_108343
Panther	1	1.100	-	-	O	PTHR11473
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4798
SonicParanoid	1	1.000	-	-		X3954
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740