Protein Alignment ple and tph-1

DIOPT Version :10

• Sequence 1: NP_476898.1
• Gene: ple / 38746
• FlyBaseID: FBgn0005626
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_495584.4
• Gene: tph-1 / 174227
• WormBaseID: WBGene00006600
• Length: 532
• Species: Caenorhabditis elegans
• Alignment Length: 521
• Identity: 190/521 - (36%)
• Similarity: 280/521 - (53%)
• Gaps: 92/521 - (17%)

  Fly    98 YVPVEEDVE-----FESVEQEQSESQSQEPEGNQQPTKNDYGLTEDEILLANAASESSDAEAAMQ 157
            :|| ||||:     ..:|.:|.|..:..|.||.|..|           ::..::..|.|.
 Worm    54 FVP-EEDVKQLFTPTRTVRREASIREGDEEEGVQILT-----------IIVKSSRVSEDI----- 101

  Fly   158 SAALVVRLKEGISSLGRILKAIETFHGTVQHVESRQSRVEGVDH--DVLIKLDMTRGNLLQLIRS 220
             :.::..|.:               |..::|:|:|.|: :|...  |||::::
 Worm   102 -SKMIANLPD---------------HTRIKHLETRDSQ-DGSSKTMDVLLEIE------------ 137

  Fly   221 LRQSGSFSSMNLMADNNLNVK--------------------------APWFPKHASELDNCNHLM 259
            |...|...:|:||..|.|:|.                          :.||||...:||.|...:
 Worm   138 LFHYGKQEAMDLMRLNGLDVHEVSSTIRPTAIKEQYTEPGSDDATTGSEWFPKSIYDLDICAKRV 202

  Fly   260 TKYEPDLDMNHPGFADKVYRQRRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPK 324
            ..|...||.:||||.|..|||||...||:|..||:|:|||..:|:..|.|||..:::.:::|..|
 Worm   203 IMYGAGLDADHPGFKDTEYRQRRMMFAELALNYKHGEPIPRTEYTSSERKTWGIIYRKLRELHKK 267

  Fly   325 HACAEYRAAFQKLQDEQIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQS 389
            |||.::...|:.|:....:.|..:|||:::..||:..|||.:||.||.|:||||||.||:|:|..
 Worm   268 HACKQFLDNFELLERHCGYSENNIPQLEDICKFLKAKTGFRVRPVAGYLSARDFLAGLAYRVFFC 332

  Fly   390 TQYVRHVNSPYHTPEPDSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVE 454
            ||||||...|::|||||::|||:|||.|.|||.||||||||||||||||:|:::||:|:|:|::|
 Worm   333 TQYVRHHADPFYTPEPDTVHELMGHMALFADPDFAQFSQEIGLASLGASEEDLKKLATLYFFSIE 397

  Fly   455 FGLCKE-------------HGQIKAYGAGLLSSYGELLHAISDKCEHRAFEPASTAVQPYQDQEY 506
            |||..:             |.:.|.||||||||.|||.||:........|:|.....|......:
 Worm   398 FGLSSDDAADSPVKENGSNHERFKVYGAGLLSSAGELQHAVEGSATIIRFDPDRVVEQECLITTF 462

  Fly   507 QPIYYVAESFEDAKDKFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLVHQMNTEILHLTNA 571
            |..|:...:||:|:.|.|.:.:.|.|||.||:||:||.||||::...:...|:.:.::|..|..|
 Worm   463 QSAYFYTRNFEEAQQKLRMFTNNMKRPFIVRYNPYTESVEVLNNSRSIMLAVNSLRSDINLLAGA 527

  Fly   572 I 572
            :
 Worm   528 L 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ple	NP_476898.1	Tyr_3_monoox	130..576	CDD:130336	176/484 (36%)
tph-1	NP_495584.4	Trp_5_monoox	57..532	CDD:130337	188/517 (36%)