Protein Alignment ple and cat-2

DIOPT Version :9

• Sequence 1: NP_001286955.1
• Gene: ple / 38746
• FlyBaseID: FBgn0005626
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_001293483.1
• Gene: cat-2 / 173411
• WormBaseID: WBGene00000296
• Length: 524
• Species: Caenorhabditis elegans
• Alignment Length: 561
• Identity: 223/561 - (39%)
• Similarity: 313/561 - (55%)
• Gaps: 79/561 - (14%)

  Fly    23 ENGYPSRRRSLVDDARFETLVVKQTKQTVLEEARSKANDDSLEDCIVQAQEHIPSEQDVELQDEH 87
            ||....||.|||..|..||...|..::....:.|.:..|......|:|           :|.||.
 Worm    31 ENSKNPRRYSLVHQASCETQHHKGIRRQNTIQHRKQLTDQMRCQKILQ-----------QLNDEG 84

  Fly    88 ANLENLPLEEYVPVEEDV---EFESVEQEQSESQSQEPEGNQQPTKNDYGLTEDEILLANAASES 149
            .        |.:....||   ||..:                        ||..:..|:|..|:
 Worm    85 I--------EVIFTANDVTPIEFSII------------------------LTSTDPTLSNFVSD- 116

  Fly   150 SDAEAAMQSAALVVRLKEGISSLGRILKAIETFHGTVQHVESRQSRVEGVDHDVLIKLDMTRGNL 214
                                     ||:.:.:....:.|||:|.:.   ..||||:....|:..|
 Worm   117 -------------------------ILQNMSSAKVQICHVETRGNE---ASHDVLLACKATKNQL 153

  Fly   215 LQLIRSLRQS----GSFSSMNLMADNNLNVKAPWFPKHASELDNCNHLMTKYEPDLDMNHPGFAD 275
            :.....|.|:    ..||.......:..|....|||:|.||||.|:..:|||||..|..|||..|
 Worm   154 IHSAELLTQNHVALTKFSIFAKKLSDEKNQSQIWFPRHISELDQCSKCITKYEPTTDPRHPGHGD 218

  Fly   276 KVYRQRRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAFQKLQDE 340
            ..|..|||.:.:.|..:|:||.|.::||::.|..||::|::.:.||...|.||.||...:.||:|
 Worm   219 VAYIARRKFLNDQALEFKFGDEIGYVDYTEEEHATWKAVYEKLGDLHLSHTCAVYRQNLKILQEE 283

  Fly   341 QIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSPYHTPEP 405
            ::....|:||:::::.||:|.|||.|||.:|||:|||||||||||:||:|.|:||..||:|:|||
 Worm   284 KVLTADRIPQIRDVNKFLQKKTGFELRPCSGLLSARDFLASLAFRVFQTTTYLRHHKSPHHSPEP 348

  Fly   406 DSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEHGQIKAYGAG 470
            |.|||||||:|:.:||..||.||:|||.|||||||.||||||||||.||||||||.|::||.|||
 Worm   349 DLIHELLGHVPMFSDPLLAQMSQDIGLMSLGASDEHIEKLSTVYWFIVEFGLCKEDGKLKAIGAG 413

  Fly   471 LLSSYGELLHAISDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAKDKFRRWVSTMSRPFE 535
            |||:||||:||.||..||:.|:||.||||.|:|.:|||:|:||:|..||..|.|::.|:|.|||.
 Worm   414 LLSAYGELMHACSDAPEHKDFDPAVTAVQKYEDDDYQPLYFVADSIHDALAKLRKYASSMDRPFS 478

  Fly   536 VRFNPHTERVEVLDSVDKLETLVHQMNTEILHLTNAISKLR 576
            |.::|.|:.:|.::|...||....:::.::..:|:|..:::
 Worm   479 VVYDPFTKSIEAIESSADLEKAFSRLSNDLSAITHAADRMK 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ple	NP_001286955.1	Tyr_3_monoox	130..576	CDD:130336	200/449 (45%)
		ACT	130..234	CDD:298841	21/107 (20%)
		Biopterin_H	243..573	CDD:278766	178/329 (54%)
cat-2	NP_001293483.1	Biopterin_H	187..514	CDD:366046	177/326 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159583
Domainoid	1	1.000	386	1.000	Domainoid score	I423
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H307
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1094
Isobase	1	0.950	-	0	Normalized mean entropy	S3178
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	1	1.000	-	-		oto17219
orthoMCL	1	0.900	-	-		OOG6_108343
Panther	1	1.100	-	-	LDO	PTHR11473
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3954
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.810