DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ple and tph2

DIOPT Version :9

Sequence 1:	NP_001286955.1	Gene:	ple / 38746	FlyBaseID:	FBgn0005626	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	XP_002940217.3	Gene:	tph2 / 100486097	XenbaseID:	XB-GENE-958329	Length:	485	Species:	Xenopus tropicalis

Alignment Length:	433	Identity:	188/433 - (43%)
Similarity:	290/433 - (66%)	Gaps:	6/433 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 SDAEAAMQSAALVVRLKEGISSLGRILKAIETFHGTVQHVESRQSRVEGVDHDVLIKLDMTRGNL 214
            ::|.|..:..|:::.:|..:..|.:.||..:..:..:.|:|||:|:....:.|:.::.:.|:...
Frog    50 TEATAETERTAVILTMKNEVGGLLQNLKIFKEKYVNIIHIESRKSKGNKSEVDMYVEFECTKKKC 114

  Fly   215 LQLIRSLRQSGSFSSMNLM-----ADNNLNVKAPWFPKHASELDNCNHLMTKYEPDLDMNHPGFA 274
            .:|...|:......|:|.:     .|..|. ...|||:..||||.|::.:..|..:||.:||||.
Frog   115 QELQHLLKLQSGIISVNPVERIWRKDEELE-GVLWFPRKISELDKCSNRVLMYGSELDADHPGFK 178

  Fly   275 DKVYRQRRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAFQKLQD 339
            |.|||||||...::|..||||.|||.::|:..|:|||.:|||.:..|.|.|||.||......|..
Frog   179 DNVYRQRRKYFVDVAMDYKYGQPIPRVEYTAEEIKTWGTVFKELTKLYPTHACKEYLKNLPLLTK 243

  Fly   340 EQIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSPYHTPE 404
            ...:.|..:|||::::.||::.:||::||.||.|:.|||||.||:|:|..|||:||.:.|.:|||
Frog   244 YCGYREDNVPQLEDVAIFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPE 308

  Fly   405 PDSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEHGQIKAYGA 469
            ||:.||||||:||||||.||||||||||||||||||:::||:|.|:||:||||||:.||::||||
Frog   309 PDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQDGQLRAYGA 373

  Fly   470 GLLSSYGELLHAISDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAKDKFRRWVSTMSRPF 534
            |||||.|||.||:|||...:.|:|.:|.:|......:|..|:|:|||::||:|.|.:..:::|||
Frog   374 GLLSSIGELKHALSDKAIVKTFDPKTTCLQECIITTFQDSYFVSESFDEAKEKMREFAKSINRPF 438

  Fly   535 EVRFNPHTERVEVLDSVDKLETLVHQMNTEILHLTNAISKLRR 577
            .|.|||:|:.:|:|::...:|.::..:.:::..:::|::|:.:
Frog   439 SVYFNPYTQSIEILNNTRSIENVIQDLRSDLNTVSDALAKMNK 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ple	NP_001286955.1	Tyr_3_monoox	130..576	CDD:130336	188/430 (44%)
		ACT	130..234	CDD:298841	18/88 (20%)
		Biopterin_H	243..573	CDD:278766	167/329 (51%)
tph2	XP_002940217.3	ACT	59..132	CDD:415594	15/72 (21%)
tph2	XP_002940217.3	Biopterin_H	148..476	CDD:395280	166/327 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920