Protein Alignment CG8519 and RASD2

DIOPT Version :10

• Sequence 1: NP_648054.2
• Gene: CG8519 / 38745
• FlyBaseID: FBgn0035711
• Length: 207
• Species: Drosophila melanogaster
• Sequence 2: NP_055125.2
• Gene: RASD2 / 23551
• HGNCID: 18229
• Length: 266
• Species: Homo sapiens
• Alignment Length: 187
• Identity: 57/187 - (30%)
• Similarity: 92/187 - (49%)
• Gaps: 24/187 - (12%)

  Fly     3 TRGIRCKKSTLTELKIAVIGAPSVGKSALIVRFLTKRYIGEYDHQTENRYKHEAMVDGEPVLFEI 67
            |..:..|.|    .::.|:||..||||:::.|||..|:..:|....|:.::....:.|:....:|
Human    11 TLSVPAKNS----YRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVYNIRGDMYQLDI 71

  Fly    68 LDTCPKAEDEYPNAAEL-VQWADGLLLVYSITDRKSFNYIRR-------AKSDLQSDT------P 118
            |||  .....:|....| :...|..:||:|:.:|:||:.::|       .||.|::.|      |
Human    72 LDT--SGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVKSCLKNKTKEAAELP 134

  Fly   119 VQLCANKVDMVHL-RQVSRDEGEILAK-DFECKFSEVSAA--DHVDQVAEVFNELCK 171
            :.:|.||.|...| |||...|.|:|.. |..|.:.||||.  .:||::..|...:.|
Human   135 MVICGNKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVDEMFYVLFSMAK 191

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8519	NP_648054.2	P-loop containing Nucleoside Triphosphate Hydrolases	17..173	CDD:476819	54/173 (31%)
RASD2	NP_055125.2	Rhes_like	20..266	CDD:133343	54/174 (31%)
		Effector region	48..56		2/7 (29%)
		Interaction with GNB1, GNB2 and GNB3. /evidence=ECO:0000269|PubMed:19255495	189..235		1/3 (33%)