DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP1173 and Mfsd6

DIOPT Version :9

Sequence 1:	NP_648053.1	Gene:	SP1173 / 38744	FlyBaseID:	FBgn0035710	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_598590.2	Gene:	Mfsd6 / 98682	MGIID:	1922925	Length:	794	Species:	Mus musculus

Alignment Length:	725	Identity:	136/725 - (18%)
Similarity:	245/725 - (33%)	Gaps:	222/725 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RVNKTLISLKFVVFFVITGLTALHVLHATKPLL------LGLNFSEYRTITILAPFVSILGPLIA 68
            :||..|:..|...||..:...:|:      |||      ||::.|:...:..:..|:........
Mouse    64 KVNNDLLISKVFYFFFYSAYGSLY------PLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFW 122

  Fly    69 GPWADRLAAKNPNTFGKTLRVLTAVFLLISAFIYAFLFAVPEVTRRGEIREPLVSFGCDETGGFL 133
            |..|||...      ||       :.||.|...:.                 |.:.|.    ||:
Mouse   123 GVVADRFRK------GK-------IVLLFSLLCWV-----------------LFNLGI----GFV 153

  Fly   134 FQERCGSNATCSRWDQKEGKINLTRCTYSCQNPKLYEPLYVAWLAEVPTVAPSTEQSSEFDYEDE 198
                               |....||.     ||:....:...::...||.|....:..|
Mouse   154 -------------------KPATLRCL-----PKIPPTAHPTNVSHPVTVLPMNSSTVAF----- 189

  Fly   199 GSTAVTESLRTRRDVESSDPADS-AGVEAISGEVPLHRSIRQVKKPPTKVYVQPPHVCLTERNQN 262
              .:....|..:|||:.|:...: :.::.:|..:.|  :....::|.|:....|    :|....|
Mouse   190 --FSTPPKLLQKRDVQLSETEPNISDIDLVSTALTL--TSEPTRRPQTEAITHP----VTGLILN 246

  Fly   263 GEDV-VKHCHAYTEDTTSVVMDALMGSAISQEEHYDDYEGWCQYPLEGFQCHIPEEQVNYMKDFK 326
            ...| :......|.:||..|:.....                          :|.:||..:
Mouse   247 TSTVTLPPTGNVTRETTIAVVTTTKS--------------------------LPSDQVTLV---- 281

  Fly   327 HYMQNDSNCKPMIECQVVNPYHEQSVLSDSECTNTTGSVQDTLVGYTTIRLIGDIFPMAALTLLN 391
                                |.:|             .|:...:....:.:||:.|..:::|:::
Mouse   282 --------------------YDQQ-------------EVEAIFLIILVVVIIGEFFSASSVTIVD 313

  Fly   392 TAIVIAVRETSEGRGEVCRQYVWGAIGYVVL---------FSPLDLFF---------FQNEPNHD 438
            |   :.::...:.|.....|.:||::|:.:.         ::.:|:..         ::|..
Mouse   314 T---VTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIDVLIDGKGCKPPEYRNYQ--- 372

  Fly   439 AALVALIIFIVSFVLGAVVLLCATQMPLSPPEWWWHTKTGMLV-VPM------SAIRRYTPEI-- 494
                  |:|||..||..:.|:.|||.......:......|..| :|.      :.....||..
Mouse   373 ------IVFIVFGVLMTMALIVATQFRFRYNHFNNSDGKGKEVEIPQVERDNSTESSEETPTAAT 431

  Fly   495 ---------LVLTLVSILFGTF----------WSSIHSYLWWTFTDVD------AVCYSGL--IL 532
                     |:..|.|:.:|:.          :..:.::|:|...|::      .|| |.|  :.
Mouse   432 HSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVC-SVLSHVS 495

  Fly   533 ILVLFFNVDKFIEYCGHSNIFIGGLAIFVIRFTALSDAQTKWLTVIMETIEPAVIGLIWITIILY 597
            .|..:|...|.||..||..:...|||....|:..:|..:..|..:.||.::......||...|.|
Mouse   496 ELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISY 560

  Fly   598 MRHAMPRKLTATGQAIAVLAFFGLGKGFGALIGLARDERDPKLEFWSCTYQWLAI-VACVVALIY 661
            :..|:|.:|..:.|.|......|||:|.||:||      ...:.::.....:..| :||:|.|:.
Mouse   561 LSAAVPPELRTSAQGILQGLHLGLGRGCGAMIG------GVLVNYFGAAATFRGIGMACLVILLL 619

  Fly   662 FGIYNLILAP 671
            |.:...:..|
Mouse   620 FALIQWLAVP 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP1173	NP_648053.1	MFS	15..88	CDD:304372	18/78 (23%)
SP1173	NP_648053.1	Chromate_transp	<552..632	CDD:302665	25/79 (32%)
Mfsd6	NP_598590.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..47
		MFS_MFSD6	71..625	CDD:340893	132/712 (19%)
		PHA03381	666..>779	CDD:177618
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3762
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810